简介：Purpose:Tostudythecorrelationbetweenfunctionalandstructurallossinchronicglaucoma,asdetectedbyFrequencyDoublingTechnology(FDT)andHeilderbergRetinaTomograph(HRT).MaterialandMethods:60eyesof60patientswitheitherocularhypertensionorchronicopen-angleglaucomaunderwentvisualfieldtestingwithbothstandardautomated

简介：AIM:Toinvestigatechoroidalthicknessinpregnantwomenandcomparethemeasurementswiththoseofnormalnonpregnantwomen.METHODS:Usingenhanceddepthimagingopticalcoherencetomography(EDI-OCT),choroidalthicknesswasmeasuredatthefoveaandat1mmand3mmsuperior,inferior,temporal,andnasaltothefoveainbothhealthypregnantwomenandnonpregnantwomen.Pearsoncorrelationanalysiswasperformedtoevaluatetherelationshipsbetweensubfovealchoroidalthickness(SFCT)andthedemographicandocularparameters.Pooledoddsratio(OR)and95%confidenceinterval(CI)werecalculatedusingfixed-effectsmodelwhenMeta-analyseswereconducted.RESULTS:Comparisonofchoroidalthicknessbetweenthegroupsshowedthatitwassignificantlygreaterinhealthypregnantwomen’seyesthaninnormalnonpregnantwomen’seyesatalllocationsexceptat3mmsuperiorand3mmtemporalfromthefovea(P<0.05).ThemeanSFCTwas344.13±50.94μminhealthypregnantwomen’seyesand315.03±60.57μminnormalnonpregnantwomen’seyes,withastatisticallysignificantdifference(P=0.008).PearsoncorrelationanalysisshowedthatageandaxiallengthweresignificantlyrelatedtoSFCTinhealthypregnantwomen,normalnonpregnantwomen,andallsubjects.Theresultsofourcross-sectionalstudywereconsistentwiththeresultsofthefurtherMeta-analysis,withapooledweightedmeandifference(WMD)of33.66μm(95%CI:26.16to41.15)forSFCT.CONCLUSION:Ourresults,alongwiththecomprehensiveMeta-analysis,suggestthatchoroidalthicknessinhealthypregnantwomenisgreaterthanthatinnormalnonpregnantwomen.

简介：AIM:ToexplorethemolecularmechanismsinlensdevelopmentandthepathogenesisofPetersanomalyinSmad4defectivemice.METHODS:Le-CretransgenicmouselinewasemployedtoinactivateSmad4inthesurfaceectodermselectively.PathologicaltechniqueswereusedtorevealthemorphologicalchangesoftheanteriorsegmentinSmad4defectiveeye.ImmunohistochemicalstainingwasemployedtoobservetheexpressionofE-cadherin,Ncadherinanda-SMAinanteriorsegmentofSmad4defectivemiceandcontrolmiceatembryonic(E)day16.5.Real-timequantitativepolymerasechainreaction(qPCR)wasperformedtodetecttheexpressionofSnail,Zeb1,Zeb2andTwist2inlensofSmad4defectivemiceandcontrolmiceatE16.5.RESULTS:ConditionaldeletionofSmad4oneyesurfaceectodermresultedincorneaidysplasia,iridocornealangleclosure,corneolenticularadhesionsandcataractresemblingPetersanomaly.LossofSmad4functioninhibitedE-cadherinexpressioninthelensepitheliumcellsandcorneaiepitheliumcellsinSmad4defectiveeye.ExpressionofN-cadherinwasupregulatedincorneaiepitheliumandcorneaistroma.BothE-cadherinandN-cadherinweredown-regulatedatthefuturetrabecularmeshworkregioninmutanteye.TheqPCRresultsshowedthattheexpressionofTwist2wasincreasedsignificantlyinthemutantlens(P<0.01).CONCLUSION:Smad4isessentialtoeyedevelopmentandlikelyacandidatepathogenicgenetoPetersanomalybyregulatingepithelial-mesenchymaltransition.Twist2canberegulatedbySmad4andplaysanessentialroleinlensdevelopment.

简介：AIM:Tocomparetheanteriorandposteriorcornealparametersbeforeandaftercollagencross-linkingtherapyforkeratoconus.METHODS:Collagencross-linkingwasperformedin31eyesof31keratoconuspatients(meanage30.6±8.9y).Priortotreatmentandanaverage7moaftertherapy,ScheimpfluganalysiswasperformedusingPentacamHR.Inadditiontocornealthicknessassessments,cornealradius,elevation,andaberrometricmeasurementswereperformedbothonanteriorandposteriorcornealsurfaces.Dataobtainedbeforeandaftersurgerywerestatisticallyanalyzed.RESULTS:Intermsofhorizontalandverticalcornealradius,andcentralcornealthicknessnodeviationswereobservedanaverage7moafteroperation.Cornealhigherorderaberrationshowednodifferenceneitheronanteriornoronposteriorcornealsurfaces.Duringfollow-upperiod,nosignificantdeviationwasdetectedregardingelevationvaluesobtainedbymeasurementinmmunitsbetweenthe3.0-8.0mm-zones.CONCLUSION:Cornealstabilizationcouldbeobservedintermsofanteriorandposteriorcornealsurfaces,elevationandhigherorderaberrationvalues7moaftercollagencross-linkingtherapyforkeratoconus.

简介：这研究在跟随加速的transepithelial的keratoconus角膜评估了临床的结果角膜的骨胶原cross-linking(CXL)(AvedroKXL?系统，麻省沃尔瑟姆，美国)超过一年后续。光连贯断层摄影术(10月)测量的分界线的吝啬的深度是205.19???吳????????<

简介：·AIM:Toevaluateandcomparetheefficacyandstabilityofintrastromalcornealringsegment(ICRs)implantationwithcross-linking(CXL)usingdifferentsequenceandtiming.·METHODS:Inthissingleretrospectivestudy,86keratoconiceyessubjectedtheICRsimplantation.Weanalyzedonly41eyesthathadcompletefollow-ups.Theyweredividedintothreegroups:ICRsimplantationwasappliedonly(groupnormal),ICRsfirstfollowedbyCXLimmediately(groupCXL-S),CXLfirstfollowedbyICRslongafter(groupCXL-B).Thevisualacuity,refractiveresults,keratometrywerecomparedpreoperativelyand1ypostoperatively.Theirdifferencesamongthethreegroupswerealsoanalyzed.·RESULTS:Groupnormalcomprised25eyes,groupCXL-S8eyes,andgroupCXL-B8eyes.Therewereimprovementsinthemeanuncorrecteddistancevisualacuity(UDVA)andthemeancorrecteddistancevisualacuity(CDVA)comparedpreoperativelyand1ypostoperatively[UDVA:0.31(P=0.030)logarithmicminimumangleofresolution(logMAR)groupnormal,0.4(P=0.020)groupCXL-S,0.45(P=0.001)groupCXL-B;CDVA:0.21logMAR(P=0.013)groupnormal,0.30(P=0.036)groupCXL-S;0.26(P=0.000)groupCXL-B].Therefractiveandtopographicoutcomesalsoshowedimprovements.Intermsofcomparisonsamongthethreegroups,allthePvalueswereabove0.05,showingnosignificantdifference.ButonlygroupCXL-BhadimprovementinUDVAandCDVAforallthepatients.·CONCLUSION:Withsafetyandgoodvisualoutcomes,ICRsimplantationisaviablealternativeforkeratoconus.Nosignificantdifferencewasfoundamongthesethreegroups.

简介：AIM:Toevaluatewhetherglaucomatousvisualfielddefectparticularlythepatternstandarddeviation(PSD)ofHumphreyvisualfieldcouldbeassociatedwithvisualevokedpotential(VEP)parametersofpatientshavingprimaryopenangleglaucoma(POAG).METHODS:VisualfieldbyHumphreyperimetryandsimultaneousrecordingsofpatternreversalvisualevokedpotential(PRVEP)wereassessedin100patientswithPOAG.ThestimulusconfigurationforVEPrecordingsconsistedofthetransientpatternreversalmethodinwhichablackandwhitecheckerboardpatternwasgenerated(fullfield)anddisplayedonVEPmonitor(colour14')byanelectronicpatternregeneratorinbuiltinanevokedpotentialrecorder(RMSEMGEPMARKII).RESULTS:Theresultsofourstudyindicatethatthereisahighlysignificant(P<0.001)negativecorrelationofP100amplitudeandastatisticallysignificant(P<0.05)positivecorrelationofN70latency,P100latencyandN155latencywiththePSDofHumphreyvisualfieldinthesubjectsofPOAGinvariousagegroupsasevaluatedbyStudent’st-test.CONCLUSION:ProlongationofVEPlatenciesweremirroredbyacorrespondingincreaseofPSDvalues.Conversely,asPSDincreasesthemagnitudeofVEPexcursionswerefoundtobediminished.

简介：

简介：为neovascular在诊断和预后调查neutrophil-to-lymphocyte比率(NLR)和platelet-to-lymphocyte比率(PLR)的地方年龄相关的有斑点的退化(AMD).METHODSOne百个AMD病人和100健康控制在学习被包括。血样品从静脉的血被获得，它被用于平淡的分析，并且这些样品被使遭到完成血计数。NLR被定义为淋巴细胞的数字划分的嗜中性的计数，并且PLR被定义为lymphocytes.RESULTSNo的数字划分的血小板计数统计上重要的差别以人口统计的特征在考虑下面在二个组之间被观察(P>0.05)。在耐心的组的平均NLR被发现在健康控制组比那显著地高(P<0.05)。平均PLR作为与控制组相比在耐心的组是显著地更高的(P<0.05)。当最好改正的视觉尖酸(BCVA)增加了，NLR和PLR减少了(在49.8%和63.0%点的重要否定关联，分别地)而当中央有斑点的厚度(CMT)增加了，NLR和PLR增加了(在59.3%和70.0%点的重要积极关联，分别地).CONCLUSIONNLR和PLR层次作为与健康控制相比在neovascularAMD病人之中是更高的组。NLR和PLR层次被发现与BCVA并且直接相反地成正比与CMT成正比。

简介：AIM:Todeterminethedistributionsofcentralcornealthickness(CCT)andintraocularpressure(IOP)inemmetropiceyesofhealthychildrenofPalestine.METHODS:Thisrepresentativecrosssectionalstudyincludedatotalof1156eyesfrom578healthyschoolchildrenaged7-15y.Inclusioncriteriaincludedemmetropia,noprevioushistoryofocularorsystemicdiseases,noprevioushistoryofcontactlensuse,andtheavailabilityofbotheyes.CCTandIOPweremeasuredusingultrasoundpachymeterandGoldmannapplanationtonometer,respectively.Therelationshipoftheresultswithageandgenderwasinvestigated.RESULTS:Themeanageofschoolchildrenwas11.13±2.8y.MeanCCTwas542.2±37.4and544.3±39.2μmforrightandlefteyes,respectively.MeanIOPwas12.5±2.2and12.3±2.2mmHgforrightandlefteyes,respectively.ApositivecorrelationwasobservedbetweenCCTandIOPoftherighteye(P<0.001,R=0.358)andCCTandIOPofthelefteye(P<0.001,R=0.324).NosignificantdifferenceswereobservedinCCTandIOPduetoageorgender(P>0.05).ThereweresignificantdifferencesinmeanCCTandIOPbetweenrightandlefteyes(P=0.004,P=0.001,respectively).CONCLUSION:ApopulationprofileofCCTandIOPisestablishedinPalestinianchildrenforthefirsttime.MeanCCTiscomparabletosomestudiesbutdifferfromothers.MeanIOPisconsiderablylowerthanthatofmajoritychildrenofotherethnicgroups.Intereyedifferenceofmorethan36μminCCT,and5mmHginIOPshouldpromptevaluationforpotentialoculardisorders.

简介：AIMTo比较在两个的灌注由使用光连贯断层摄影术angiography(OCTA)与正常控制组一起单方的自发的有斑点的洞(IMH)看的眼的神经头(ONH)并且调查它的correlationship，有斑点的血perfusion.METHODSWe表现了包括了19个病人与的未来、代表性的研究完整厚度单方IMH和24匹配年龄、匹配性的控制。所有参加者收到了OCTA测试。ONH灌注被peripapillary和全部的区域在脸(peripapillary和眼的圆盘的和)评估。在ONH和parafovea之间的潜在的correlationship被暗示。所有数据用介绍的ONH的nonparametrictest.RESULTSThe平均数值被执行那正常控制>IMH>未受影响的眼睛。一个统计变化在这个区域在三个组之间被发现时间(P=0.007)。容器密度著名地在层上减少了表面，深并且在IMH的parafovea区域的脉络膜组。关联词系数在脸和深视网膜完全分别地显示出那：r=0.528，peripapillary和深视网膜：r=0.525，在脸和choriocapillaries整个：r=0.569，peripapillary和choriocapillaries：r=0.504.CONCLUSIONOur学习在IMH眼睛在IMH病人和ONH的容器密度的两只眼睛表明减少的ONH容器密度断然在parafoveal与毛状的视网膜和choriocapillary被相关。容器密度的减小可以在IMH眼睛显示hypoperfusion。

简介：CornealdiseasesarecurrentlythesecondmaincauseofblindnessinChina.Althoughmostofthecornealblindnesscouldbetreatedbycornealtransplantation,onlyabout10000operationswerecarriedouteachyearowingtothesevereshortageofcornealdonorsandlimitedeyebankprograms.AfeasiblecorneadonationprogramwasestablishedthroughtheorganizationoftheRedCross,andinsitucornealremovaltechniquesweredevelopedtoavoidconflictswithChinesetraditionsofkeepingthedeceasedintact.Thenumberofdonatedcorneas,whichhadasafeandsecurequality,increasedsignificantlyyearbyyear.

简介：

简介：AIM:ToevaluatetheeffectofCollagencross-linkingonthepreventionofmeltinginrabbitcorneasafteralkaliburn.·METHODS:TwentyNewZealandwhiterabbitswererandomlydividedintomodelcontrolgroupandcollagencross-linkingtreatmentgroup.Thesecondgroupofrabbitsreceivedcollagencrosslinkedtreatment.Bothgroupswereappliedwithantibioticeyedropstopreventinfection.Thecorneaswereevaluatedformelting,opacity,pathologicalandimmunohistochemistry,recordthechangeswhen28daysaftertheanimalswerekilled.·RESULTS:Inthecontrolgroup,6outof8rabbitsshowedcornealmeltingafterinjury(14±4)days,whiletwocornealperforated.Incollagencross-linkingtreatmentgroup,onerabbitshowedcornealmeltingafterinjury23days,withoutcornealperforation;cornealdissolutionratebetweenthetwogroupswassignificantlydifferent(P<0.05).Pathologicalexaminationsuggestedthatinthetreatmentgroup,mildcornealedema,milddamagetocollagenfibers,inflammatorycellinfiltrationwassignificantlylessthanthecontrolgroup.Immunohistochemistryshowedthatcornealcollagenfibersarrangedinneatrowsinthecontrolgroup.·CONCLUSION:Collagencross-linkingtreatmentnotonlycanpreventanddelaythecornealmeltingafteralkaliburn,butalsocanreducethedestructionofcornealcollagenfibersandinfiltrationofinflammatorycellsinthecornealtissue.