简介:目的观察1.25(OH)2D3(罗钙全)口服冲击剂量对纠正血液透析患者血清钙、磷代谢紊乱的疗效及甲状旁腺功能的影响。方法选择36例血液透析患者为治疗口服,1.25(OH)2D3剂量2-4ug/次,每周2次;选择32例常规治疗组剂量0.25ug/次,每天一次;10例为正常健康人对照组。结果冲击量治疗组与常规治疗组,血清钙明显升高,血清磷降低,PTH在常规组轻度降低,而冲击量组显著降低,但无统计学意义,临床症状观察冲击组症状明显好转,治疗过程中无明显副作用。结论1.25(OH)2D3口服冲击量治疗血液透析患者血清钙磷代谢紊乱改善甲状旁腺功能亢进疗效较佳,不失临床治疗的好方法。
简介:【摘要】目的:研究促甲状腺激素( TSH)抑制治疗对女性分化型甲状腺癌( DTC )患者血清 25( OH) VitD及骨密度 的影响。方法:在我院收治的女性 DTC患者中选取 50 例,给予甲状腺癌根治手术,清除甲状腺成功。术后予优甲乐行 TSH抑制治疗,治疗
简介:摘要目的分析血25-(OH)D3水平和幼儿期反复呼吸道感染之间的关系。方法将2017.02.01日至2017.09.01日在本院接受治疗的50例反复呼吸道感染的幼儿期患儿(观察组)及50例健康体检儿童(对照组)作为研究对象。对比两组血25-(OH)D3水平、每天户外活动时间以及维生素D制剂补充情况。结果观察组患儿的血25-(OH)D3水平(24.26±19.64)nmol/L更低,血25-(OH)D3缺乏及不足率更高(46.00%、36.00%),每天户外活动时间在2小时以上的比例(38.00%)、维生素D制剂正规补充的比例(42.00%)都低于对照组(p<0.05)。结论血25-(OH)D3水平越低,幼儿期反复呼吸道感染的发生率就越高,需要合理补充维生素D制剂,多参与户外活动。
简介:摘要:SiO2f/SiO2复合材料由于物理性能良好,对信号波穿透性能好,被广泛应用到各种通讯器件中,但材料表面附着力较差,耐热性难以满足高温工作环境。因此,本文对SiO2f/SiO2复合材料表面涂层材料研究,硅元素来源为甲基三乙氧基硅烷(MTES)聚合物,硼酸(B(OH)3)作为硼源,采用溶胶凝胶法制备工艺,在乙醇中混合为聚硼硅氧烷胶液。通过试验验证不同硼含量对聚硼硅氧烷树脂的耐热性及疏水性影响;以及验证不同温度热处理下对涂层性能的影响。结果表明,本文方法较原有机树脂耐热性有所提高,承受最高稳定温度由原有的250℃提高到350℃,明显提高了复合材料的耐热程度。在对复合材料的憎水性研究中,本文方法制造得到的聚硼硅氧烷作为表面涂层,SiO2f/SiO2负荷材料吸水率由原有的1.13%降到最低0.33%。
简介:【摘要】目的: 探讨剪切波弹性成像联合血清同型半胱氨酸(Hcy)、25-羟基维生素D(25(OH)D)在勃起功能障碍患者中的诊断价值。方法: 回顾性分析2021年1月至2023年12月我院接诊的50例勃起功能障碍患者临床病理资料,设为病例组,并选择我院同期体检的健康人55例作为对照组,分析血清Hcy、25(OH)D水平变化情况及其与剪切波弹性成像联合检测的诊断价值。结果: 病例组患者血清Hcy水平显著高于对照组,25(OH)D水平显著低于对照组,差异显著(P<0.05);轻度组患者血清Hcy水平显著低于中度、重度患者,25(OH)D水平显著高于中度、重度患者,中度组患者血清Hcy水平显著低于重度患者,25(OH)D水平显著高于重度患者,(P<0.05);剪切波弹性成像结果显示,动脉性、静脉性及非血管性疲软状态下海绵体弹性均值显著高于勃起状态,(P<0.05);剪切波弹性成像结果显示,非血管性组注射血管活性药物后阴茎海绵体弹性均值比较无显著差异;动脉性组注射血管活性药物后5~10min海绵体弹性均值显著高于注射血管活性药物后15~20min,静脉性组注射血管活性药物后5~10min海绵体弹性均值显著低于注射血管活性药物后15~20min,(P<0.05);剪切波弹性成像预测勃起功能障碍的AUC为0.872,95%CI为0.803~0.941;Hcy预测勃起功能障碍的AUC为0.908,95%CI为0.855~0.962,截断值为15.67μmol/L ;25(OH)D预测勃起功能障碍的AUC为0.892,95%CI为0.826~0.958,截断值为28.16mg/L;联合检测时AUC为0.996,95%CI为0.990~1.000,较单独检测曲线下面积比较显著差异;且特异度、准确度均较单独检测更高。结论: 剪切波弹性成像可定量监测阴茎海绵体勃起后硬度变化,未来有望成为诊断勃起功能障碍病因的新方法,且联合血清Hcy、25(OH)D有一定的诊断价值,而本次研究也为治疗勃起功能障碍提供了新思路,临床应用价值高。
简介:Thecorrosionfatiguebehaviorofepoxy-coatedMg–3Al–1Znalloywasinvestigatedinairand3.5wt%NaClsolution.Epoxycoatingasanewmethodwasusedtoimprovethecorrosionfatiguepropertyofthematerial.Resultsshowthatthefatiguelimit(FL)ofthecoatedspecimensishigherthanthatoftheuncoatedspecimensin3.5wt%NaClsolutionbecauseofthestrengtheningandblockingfunctionsoftheepoxycoating.TheFLofthecoatedspecimensin3.5wt%NaClsolutionisashighasthatinair.Itimpliesthatthecoatedspecimensarenotassensitivetotheenvironmentasthemagnesiumalloy.Thelowtensilestrengthandtheshortelongationofthepureepoxycoatingleadtothatthefatiguecrackofthecoatedspecimenisalwaysinitiatedfromtheepoxy-coatingfilmPoresandpinholesacceleratethefatiguecrackinitiationprocess.PinholesarecausedbythecorrosionreactionsbetweentheepoxycoatingandtheNaClsolution.
简介:Thepreparationofcalciumphosphate(CP)coatingonaluminaceramicsusingelectricpulsestimulatingmethodhasbeeninvestigated.Thecup-shapedaluminaceramicsweresoakedinasimulatedbodyfluid(SBF),andasquarepulsepotentialwithfrequencyof1Hzandvoltageof110Vwasappliedbetweentheinnerandoutersurfacesofthealuminacup.SurfacemorphologyofCPcoatingsduringdifferentdepositionperiodswasobservedbyaPhilipsXL-30scanningelectronmicroscope(SEM).CompositionalanalysiswasexaminedbyEDAX.ThemechanismofnucleationandgrowthofCPcoatingwasdiscussed.SEMresultindicatesthatthecoatingcomprisesofalargenumberoftinyneedle-likegrainsandhasaporousmicrostructure.ThereisastrongbondbetweenthedepositedlayerandAl2O3substrate,whichmaybeduetothegentlegrowthofthebiomimeticmethod.TheEDAXanalysisindicatesthatmaincompositionofthecoatingiscalciumandphosphor.TheformationofCPcoatingmaybecontributedtothestimulationofelectricpulseandthehighionsconcentrationwhichis1.5timesoftheconcentrationofSBFsolution(1.5SBFsolution).SuchsurfacefunctionalizationmethodbyelectricpulsepotentialcanbeusedtoprepareCPcoatingonvariouselectric-insulatingbioinertmaterialsforimprovingtheirbioactivecharacter.
简介:Copolymerizationofstyrene(St)andisoprene(IP)wascarriedoutwithacatalystsystemcomposeaofanhydrouslanthanidechloridehexamethylphosphoramidecomplex(LnCl3·HMPA)andaluminumorganiccompound(AOC).Amongthecatalystsexamined,catalystNdCl3·HMPA/AI(i-Bu)3showedahighactivityinthecopolymerizationundercertainconditionsgivingcopolymers(5%—15%Stcontent)withhighcis-1,4microstructureinIPunits(>95%).TheeffectsofHMPA/Ndmolarratio,Al/Ndmolarratio,monomer/Ndmolarratio,Stfeedratio,andthereactiontimeoncopolymerizationwereexaminedwiththiscatalyticsystem.Theobtainedcopolymerswerecharacterizedby^1Hand^13CNMRspectroscopiesandgel-permeationchromatography(GPC).
简介:AseriesofoxideizedCO-K-Mo/γ-Al2O3catalystsamples,preparedbyimpregnatingoxidizedK-Mo/γ-Al2O3sampleswithanaqueoussolutionofcalculatedCo(NO3)2andthencalcininginairattemperaturesof350℃,500℃65℃and800℃respectively,weresulfidedandtheninvestigatedfortheactivityinthesynthesisofmixedalcoholsfromCOhydrogenationunderconditionsofp=5.0MPa,T=350℃andGHSV=4800h^-1.TheresultsdemonstratethattheadditionofcobaltpromoterisfavorabletotheformationofhigheralcoholsandtheopimumcalcinationtemperaturesafterimpregnatingwithCo^2+areabout500-650℃.ThestructureofCoandMospeciesontheoxidizedandsulfidedsampleswasdeterminedbyX-raydiffraction(XRD),laserRamanspectrum(LRS)andextendedX-rayabsorptionfinestructure(EXAFS).Foroxidizedsamplecalcinedat350℃,cobaltexistsasCo3O4spectiesandcoversthesurfaceofK-Mo-Ospecies,thestructureofK-Mo-OspeciesisthesameasthatinK-Mo/Al2O3sample.TheinteractionbetweencobaltandK-Mo-Ospeciesisrelativelyweak.Aftersulfidation.Cobaltexistsassulfidecrystalliteswithanoctahedralcoordinatedstructure,andmolybdenumasMoS2crystallites.Foroxidizedsamplescalcinedat500-650℃,CocomponentinteractswiththeK-Mo-Ospeciesanddestroysthelong-rangeorderoftheK-Mo-Ospectesgradually,Aftersulfidation.CotendstoexistasasulfidewithtetrahedralcoordinatedstructureandMostillasMoS2crystallites.Foroxidizedsamplecalcinedat800℃,CocomponentexistsmainlyasCoAl2O4species,mostofwhichcannotbesultidedduringsulfidation.
简介:ThispapertestifiesthataluminiumandsiliconaswellastheircarbidexandnitridescanreactwithCOincarbon-containingzonetoformAl2O3andSiOgasthroughexperimentandthermodyanmicanalysis,ThegasesdiffusetooxidizedzoneandreactwithoxidizerssuchasCO2,Asaresult,Al2O3andSiO2aredepositedfromthegases,wihichblockthepores,thusreducetheamountofgasdiffusionandincreaseoxidationresistnaceofcarbon-containingmaterials.
简介:摘要目的优化前列腺特异膜抗原(PSMA)靶向分子探针Al18F-PSMA-11的制备条件和方法,研究该探针临床转化的可行性。方法PSMA-N,N′-双[2-羟基-5-(羧乙基)苄基]乙二胺-N,N′-二乙酸(HBED-CC)溶于CH3COONH4缓冲液(pH=4.8)中,与溶于纯水的AlCl3·3H2O按照物质的量比1∶1于60 ℃反应10 min,经tC18柱纯化并冻干制成[Al]-PSMA-11。用18F-标记[Al]-PSMA-11,考察反应温度和pH值对标记率的影响。标记产物经tC18柱纯化和无菌滤膜过滤制得Al18F-PSMA-11。对比Al18F-PSMA-11与68Ga-PSMA-11在5名健康志愿者[年龄(56±8)岁]的体内分布,采用两独立样本t检验比较2组SUVmax的差异。对1例前列腺癌根治术后生化复发患者(70岁)行Al18F-PSMA-11 PET/CT早期及延迟显像以评估其对前列腺癌复发监测的潜力。结果Al18F-PSMA-11在pH=4.8,60 ℃水相中反应15 min的标记率为(42.3±3.2)%,tC18柱纯化后产品室温放置3 h后的放化纯仍大于95%。Al18F-PSMA-11与68Ga-PSMA-11体内分布基本一致,主要浓聚在泪腺、腮腺、颌下腺、肝脏、脾脏、肾脏、膀胱及部分肠道,且2组各主要靶器官的SUVmax差异均无统计学意义(t值:0.19~1.95,均P>0.05)。前列腺癌生化复发患者的Al18F-PSMA-11延迟显像(注射后3 h)可见多发骨转移灶。结论采用[Al]-PSMA-11预螯合的方法合成的Al18F-PSMA-11可以满足临床PET显像应用,对前列腺癌转移灶有良好的定位和显像潜能。
简介:摘要目的自动化合成Al18F-1,4,7-三氮杂环壬烷-1,4,7-三乙酸(NOTA)-成纤维细胞激活蛋白抑制剂(FAPI)-04,并进行体内显像,评估其诊断肿瘤的效能。方法利用All-in-one型自动合成模块合成Al18F-NOTA-FAPI-04,并进行质量分析;取3只正常BALB/c小鼠和3只4T1小鼠乳腺癌荷瘤小鼠进行PET/CT显像,观察体内Al18F-NOTA-FAPI-04分布情况;对1例肝细胞肝癌患者(男,51岁)进行Al18F-NOTA-FAPI-04和18F-FDG PET/CT显像,评估其对肝癌的诊断效能。结果自动化合成Al18F-NOTA-FAPI-04的时间约为35 min,合成产率约为(25.2±1.9)%(衰减校正后,n=3),产品为无色透明溶液,pH值为7.0~7.5,其比活度为(46.11±3.07) GBq/μmol(衰减校正后,n=3),放化纯大于99.0%,室温放置6 h后放化纯仍大于98.0%。小鼠体内显像示Al18F-NOTA-FAPI-04的生理性摄取主要在胆道系统和膀胱中,且高度浓聚于肿瘤病灶区域;肝细胞肝癌患者PET/CT显像示Al18F-NOTA-FAPI-04和18F-FDG PET/CT在胸骨旁淋巴结、膈上前组淋巴结、肝门区淋巴结、胰十二指肠韧带区淋巴结、腹主动脉旁淋巴结的靶本比值(TBR)分别为4.1、8.9、5.4、4.8、2.2和1.0、2.8、5.0、2.1、1.1。结论基于All-in-one型自动合成模块合成Al18F-NOTA-FAPI-04,合成时间较短、产率高、稳定性好,高度浓聚于病灶区域,其PET图像对比度高,诊断性能优异。