简介:目的探讨环氧化酶2(COX-2)及核因子κB(NF—κB)蛋白在胃黏膜相关(MALT)淋巴瘤组织中的表达及其临床意义。方法采用Envision二步法检测47例MALT淋巴瘤组织中COX-2和NF—κB蛋白的表达,并对其与幽门螺杆菌(Hp)感染、肿瘤大小和临床病理分期及浸润深度等指标的相关性进行分析。结果本组MALT淋巴瘤组织中COX-2和NF—κB蛋白阳性表达率分别为48.9%(23/47)和36.2%(17/47),两者表达呈正相关关系(r=0.326,P〈0.05);COX-2表达与伽感染、肿瘤临床病理分期和浸润深度及肿瘤大小明显相关(P〈0.05)。生存分析显示,COX-2阳性组病例的存活时间(59.9个月)短于阴性组(77.8个月),但两组间差异无统计学意义(P〉0.05);NF—κB阳性组病例的存活时间(26个月)显著短于阴性组(123.2个月),差异具有统计学意义(P〈0.05)。肿瘤临床病理分期是胃MALT淋巴瘤预后的独立影响因素(风险度为3.041,回归系数为1.112,Wald统计量为13.985,P〈0.01),且与预后呈负相关;而COX-2和NF—κB均不是影响预后的独立因素。结论COX-2表达上调和NF-κB激活与胃MALT淋巴瘤伽感染有关,且表达水平与肿瘤进展及预后密切相关。
简介:AbstractChronic hepatitis B virus (HBV) infection remains a global health burden. Timely and effective antiviral therapy is beneficial for patients with HBV infection. With existing antiviral drugs, including nucleos(t)ide analogs and interferon-alfa, patients can achieve viral suppression with improved prognosis. However, the rate of hepatitis B surface antigen loss is low. To achieve a functional cure and even complete cure in chronic hepatitis B patients, new antivirals need to be developed. In this review, we summarized the advantages and disadvantages of existing antiviral drugs and focused on new antivirals including direct-acting antiviral drugs and immunotherapeutic approaches.
简介:AbstractGroup B streptococcus (GBS) is a leading cause of neonatal infection. Maternal vaginal-rectal colonization with GBS during the intrapartum period is a prerequisite for GBS early-onset disease (EOD). The obstetric measures for effective prevention of GBS EOD include universal prenatal screening by vaginal-rectal culture, correct specimen collection and processing, appropriate implementation of intrapartum antibiotic prophylaxis, and coordination with pediatric care providers. It is now recommended to universal screen GBS between 360/7 and 376/7 weeks of gestation and to identify groups of women who are eligible for intravenous intrapartum antibiotic prophylaxis as a means of preventing GBS EOD.
简介:摘要目的本次研究主要分析在异位妊娠患者诊断过程中运用腹部B超与阴道B超的临床价值。方法本次研究范围限定在本院2016年1月—2017年1月间收治的异位妊娠患者当中。研究样本需求量为50例,采用随机盲选法将其分为对照组与观察组,对照组患者采用腹部B超进行诊断,观察组患者采用阴道B超进行诊断,将两组患者诊断符合率、不同类型异位妊娠诊断结果等作为对比依据。结果(1)观察组患者诊断符合率明显高于对照组患者(P<0.05);(2)观察组患者不同类型异位妊娠诊断结果优异于对照组患者(P<0.05)。结论本次研究证明,在异位妊娠患者诊断过程中运用阴道B超进行诊断,有利于提高诊断准确率,且适合在各种类型的异位妊娠患者诊断中进行运用。