简介：Depression/anxietyiscommonlypresentinpacedpatientsandisassociatedwithincreasedcardiovascularmorbidityandmortality.Thehighprevalenceofdepression/anxietyinpacedpatientssupportsastrategyofincreasedawarenessandtreatmentfordepression/anxietyinpacedpatients.Health-relatedqualityoflife(HRQoL)isbeingincreasinglyconsideredasanexpectedout-comeoftherapeuticinterventionsandrehabilitationprogramsinclinicalcardiologyincludingpatientsbeforeandafterpacemaker(PM)implantation.Thismultispecialtyconsensusdocumentreviewstheevidencelinkingdepression/anxietywitharrhythmiaandcardiacpacing;HRQoLandcardiacpacing,atthesametime,providesrecommendationsforhealthcareprovidersforthetreatmentofdepression/anxiety.

简介：ObjectivesTostudywhetherchangeofBNPlevelsreflectthechangeofcardiacfunctionandtoinvestigatetheshort-termprognosticpotentialofBNPandQOLinpatientswithCHF.Methods96consecutivepatientsadmittedwithCHFbetweenSeptember2002andJanuary2003werestudied,uponentrythestudy,BNPlevelsweremeasured,Patientsadministeredthedisease-specificqualityoflifequestionnaireMinnesotalivingwithheartfailurequestionnaire(LiHFe)within1day.BNPlevelsandadministeringLiHFewererepeatedthreemonthslater.ResultsBNPlevelswereincreasedproportionaltotheseverityofcardiacfunction.PhysicaldomainandtotalscoreofLiHFeweresignificantlycorrelatedtotheseverityofCHF(p＜0.05).BNPlevelsweredecreasedinimprovinggroup(p=0.032).IndeterioratinggroupBNPlevelsincreased(P=0.043).Kaplan-meieranalysisaccordingtoBNPlevelcutoffpoint150ng/l,thelifecurveofhigherBNPlevelgroupwassignificantlylowerthanthelowergroup(p=0.001).Inunivariatelogisticregression,NYHAclass,BNP,LVEF,LVEDD,heartsize,totalscoreofLiHFe,physicaldomainofLiHFeandtheemotionaldomainofLiHFewereallsignificantprognosticfactorsofCHF(p＜0.05forall).Whileinmultipleregression,onlyBNPlevel(p=0.036)andtheemotionaldomainofLiHFe(p=0.025)wereindependentprognosticfactors.ConclusionsChangeofBNPreflectsthetreatmentefficacyofCHF.BNPandQOLarethetwomajorshort-timeprognosticfactorsofthechronicheartfailurepatients.