简介：BACKGROUND:ResearchfocusedonthequalityoflifeofepilepticpatientsbeganonlyveryrecentlyinChina;inparticular,mostresearchhasfocusedonchildren,butlessonepilepticadults.OBJECTIVE:Tosurveyandanalyze11influentialfactorsforqualityoflifeinadultswithepilepsybyusingqualityoflifeepilepsy-31scale.DESIGN:Cross-sectionalstudy.SETTING:DepartmentofNeurology,FirstHospitalAffiliatedtoJinanUniversity;DepartmentofNeurology,FirstAffiliatedHospitalofWenzhouMedicalCollege.PARTICIPANTS:Atotalof107adultswithepilepsyforlongerthanoneyearwereselectedfromDepartmentofNeurology,FirstHospitalAffiliatedtoJinanUniversitybetweenMarch2004andDecember2006.TheincludedpatientsmettheClassificationandDiagnosticCriteriaofEpilepticAttackpublishedbyInternationalAnti-EpilepsyLeaguein1981,andtheyprovidedinformedconsent.METHODS:Generalstates,includingcourse,attackfrequency,marriagestatus,educationallevel,occupationaltypes,economicstatus,attacktypes,drugtypes,anddrugamount,wererecorded.ThereweresevenaspectsintheQualityofLifeEpilepsy-31scale,includingattackworry,lifesatisfaction,emotion,vigor/tiredness,druginfluence,cognitivefunction,andsocialfunction.Thescorespositivelycorrelatedwiththequalityoflife.Possibleinfluentialfactorsforqualityoflifewereanalyzedbyone-wayANOVAandmultivariateregressionanalysis.MAINOUTCOMEMEASURES:Course,attackfrequency,marriagestatus,educationallevel,occupationaltypes,economicstatus,attacktypes,drugtypes,drugamount,age,andsex.RESULTS:Atotalof107epilepticpatientswereincludedinthefinalanalysis.Influentialfactorsforqualityoflifeinepilepticadultsincludedattackfrequency,educationallevel,economicstatus,attacktypes,drugamount,age,andcourseofdisease(P<0.05).Amongthem,attackfrequencynegativelycorrelatedwithattackworry,lifesatisfaction,emotion,vigor/tiredness,cognitivefunc

简介：SubthalamicnucleusdeepbrainstimulationhasbecomeastandardneurosurgicaltherapyforadvancedParkinson’sdisease.Subthalamicnucleusdeepbrainstimulationcandramaticallyimprovethemotorsymptomsofcarefullyselectedpatientswiththisdisease.Surprisingly,somespecificdimensionsofqualityoflife,"psychological"aspectsandsocialadjustmentdonotalwaysimprove,andtheycouldsometimesbeevenworse.Patientsandtheirfamiliesshouldfullyunderstandthatsubthalamicnucleusdeepbrainstimulationcanalterthemotorstatusandtimeisneededtoreadapttotheirnewpostoperativestateandlifestyles.Thispaperreviewstheliteraturesregardingeffectsofbilateralsubthalamicnucleusdeepbrainstimulationonsocialadjustment,qualityoflifeandcopingstrategiesinpatientswithParkinson’sdisease.ThefindingsmayhelptounderstandthepsychosocialmaladjustmentandpoorimprovementinqualityoflifeinsomeParkinson’sdiseasepatients.

简介：BACKGROUND:Traditionalsubhibernationtherapymayeasilycausecomplications,suchasrespiratorydepressionandhyportensionbecauseofapplicationofchlorpromazinehydrochlorideandpromethazineinalargedosage.OBJECTIVE:Toobservetherapeuticeffectofmodifiedsubhibernationtherapy(alterativeapplicationoffiveanticonvulsantsaccordingtothehalflife)onstatusepilepticusinchildrenwithsevereviralencephalitis(VE).DESIGN:Contrastobservation.SETTING:DepartmentofPediatrics,theFirstHospitalofJilinUniversity.PARTICIPANTS:Theparticipantsinpresentstudywere96patientswithsevereviralencephalitisincluding52boysand44girlswhoreceivedtreatmentintheDepartmentofPediatrics,theFirstHospitalofJilinUniversityfromFebruary2000toMarch2006.AllchildrenmetthediagnosticcriteriaofZhufutongPracticePediatrics(theseventhedition).Twoweeksago,theyevergotupperrespiratoryinfectionorenteronitisandsoonbeforetheonset,spiritabnormal,behaviordisorder,limbsactdisorder,vomit,headache,convulsion,nervoussystemmasculinesignssuchaslimbsactdisord,autonomicnervedamagemanifestation,brainnervepalsy,dysreflexia,meningealirritationsign,cerebrospinalfluidandelectroencephalography(EEG)abnormity.Allparentsprovidedtheconfirmedconsent.Thepatientswererandomlydividedintocontrolgroup(n=40)andexperimentalgroup(n=56).METHODS:Patientsinthecontrolgroupreceivedanticonvulsion,icecompressandroutinetreatment.Theconvulsionwastreatedwithfivedrugs:0.5mg/kgwinterminandphenergan,respectively,100g/Lchlorpromazinehydrochloride(0.5mL/kg),5mg/kgluminal,0.3mg/kgansiolin.Whenconvulsionattacked,thosefivedrugsweregivenalternatively;however,thosewerenotgiveniftheconvulsiondidnotattack.Childrenintheexperimentalgroupweretreatedwithimprovedsubhibernationtherapybasedonroutinetreatment.Thedosagesofanticonvulsantswereasthesameasthoseinthecontrolgroup.Bas