简介：Anewconceptfordevelopmentofmetallicbiomaterialsisproposedinthisarticle,i.e.,acertainbio-functioncanberealizedforametalimplantthroughcontinuousreleaseofadesignedbio-functionalmetalelementfromsurfaceofthemetalimplantinthebodyenvironment.ThiscreativeideahasbeenverifiedtobepossiblebyseveraldifferentinvitroandinvivoexperimentalevidencesontheCu-bearingstainlesssteelsandmagnesiumbasedmetals.ItwasindicatedthatatraceamountofCureleasefromtheCu-bearingsteelscouldhaveobviousbio-functionsofreductionofthein-stentrestenosis(ISR),anti-bacterialinfection,inhibitingtheinflammatorycellsandevenpromotingtheearlyosteogenesis.Furthermore,thedegradationofmagnesiumbasedmetalsinbonescouldpromotethenewboneformation,enhancethebonemineraldensityfortheosteoporosismodeledanimal,andevenhavestronganti-bacterialabilityandstrongcytotoxicitytobonetumorcellsduetotheenhancementofpH.Specialbio-functionwithsatisfiedload-bearingcapacityformetallicbiomaterialswillbringhigherapplicationvaluesfortheimplantmadeofthisnovelmaterial.Thisisanattractivedirectionforresearchanddevelopmentwithmanychallenges,butthefinalsuccesswillbemuchbeneficialtothemajorityofpatients.