简介：所谓"男人穿什么不重要"的潜台词,即"男人只负责检阅盛装的女人。"2008年,我们大概会看到一个女人的美国梦是完满还是完结。初选中连连失利的希拉里,不知能否扭回胜局。不过,除了她的输赢,还有件事值得一看:克林顿的助选。能让老公帮忙帮到"不讲原则"(奥巴马的评价),有人说这有赖于多年前她给出的那个原谅。但,走下政坛的男人,走上去的女人,彼此不抛弃不放弃,在远见与野心之外,难道没有一点私密的原因?当然有。毕竟那是会出现在众多美国女人的梦中,被叫作比尔的男人,除了值得read的唇,他取悦女性的态度和技

简介：ＷｈｏＨｏｌｄｓＵｐＨａｌｆｏｆＨｅａｖｅｎ？ＭａｌｅＩｎｖｏｌｖｅｍｅｎｔｉｎＦａｍｉｌｙＰｌａｎｎｉｎｇ￥／／Ｗｏｍｅｎｍａｙｈｏｌｄｕｐｈａｌｆｏｆｈｅａｖｅｎｂｕｔ，ｉｎｍｏｓｔｐａｒｔｓｏｆｔｈｅｗｏｒｌｄ，ｔｈｅｙｃａｒｒｙｎｅａｒｌｙ８...

简介：用红色标志家庭中的female，用蓝色标志家庭中的male。

简介：AbstractImportance:Children with 5-alpha-reductase deficiency (5α-RD) and hypospadias present with micropenis, which makes it difficult to obtain sufficient tissue for urethral reconstruction.Objective:We investigated the therapeutic effects of oral testosterone undecanoate and established a standard androgen treatment protocol for patients with 5α-RD with micropenis.Methods:Patients with 5α-RD were treated with oral testosterone undecanoate for 3 months as a course. All patients were treated with no more than 3 courses. If the penile length (PL) reached 2.5 cm (the minimum criterion for surgery) or greater than or equal to -2.5 standard deviations (SDs) (lower limit of normal), testosterone undecanoate was considered to be effective.Results:The median age of 90 patients with 5α-RD was 1.7 years (0.9, 3.1 years). The baseline PL was 1.9 ± 0.6 cm before treatment. At the end of the first course, the PL of 63 patients (70%) reached 2.5 cm, and 49 patients (54%) reached greater than or equal to -2.5 SDs. After two treatment courses, the PL of 81 patients (90%) reached 2.5 cm, and 90 patients (100%) reached greater than or equal to -2.5 SDs. After three courses, the PL of all patients reached 2.5 cm, and all patients reached a PL greater than or equal to -2.5 SDs. No abnormal increase was observed in height-SD score, weight-SD score, or ratio of bone age to chronological age during the 1-3-year follow-up.Interpretation:After 3-9 months of treatment, PL increased to the target length. No severe adverse reactions were observed during follow-up. Testosterone undecanoate was safe and effective in children with 5α-RD with micropenis.

简介：到hamstring的BackgroundInjuries在职业cricketers是相对普通的(因为他们在许多队运动)并且自从2006.MethodsThis学习分析了发生，在板球的T20时代(20-over比赛的介绍)在发生增加了喻摧毁在各种各样的精英男性比赛的损害在一个20年的时期上打字(到2014-2015季节的1995-1996)。风险因素为喻摧毁紧张用逻辑回归分析technique.ResultsThere是的multivariate被估计276比赛时间损失喻摧毁在州或国家的运动员水平，170发生在40,145运动员火柴之一设置的澳大利亚人在一个20年的时期上记录的损害。比赛发作率的全面的率是22.5喻摧毁损害每1000队天。快保龄发作损害每1000队天是以10.9损害的率的最高的子范畴，尽管打的发作损害在50-over(一天)是特别地普通的国际比赛。在逻辑回归分析的重要风险因素，除了喻摧毁损害历史，正在是快bowler亲戚风险(RR)2.5(95%信心间隔(CI)：1.3-4.5)并且在澳大利亚RR2.3玩一场比赛(95%CI：1.3-3.9).ConclusionFastbowlers承受更多喻摧毁损害比在板球的另外的玩的角色，特别地在头等(多天)上板球。Batsmen是更可能的变得在50-over(一天)受伤了板球。在澳大利亚玩(与海外地点相比)导致增加的风险喻摧毁损害。

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简介：主要睫的运动障碍(PCD)是源于正常睫的功能的损失的正染色体后退的混乱。症状包括新生的呼吸悲痛，长期的窦炎，bronchiectasis，地点inversus，和不孕。然而，仅仅15联系PCD的基因被识别了迄今为止引起男不孕。由于PCD的基因异质，全面分子的基因测试没被认为照顾的标准。这里，我们在与与男不孕联系的PCD有关的基因因素的鉴定上提供进步的更改，总结内在的分子的机制，并且讨论这些调查结果的临床的含意。这块地里的进一步的研究将为男不孕影响诊断策略，使临床医生能向病人提供通知基因建议，并且帮助为开发直接指向的个性化的药采用治疗的最好的功课。

简介：ObjectivesToobservetheeffectsoftelmisartanandrosiglitazoneandexplorethemechanismonearlyatherogenesisinmaleratswithtype2diabetesmellitus.MethodsFortymaleSDratswererandomlyandequallydividedintofourgroups:controlgroup,type2diabetesmellitusgroup,telmisartangroupandrosiglitazonegroup.HighlipidandhighglucosewereusedforinducingDMinSDrats.Theratswereraisedforsixteenweeks.TC,TG,LDL-CandBG,PGIweremeasured.Theaortaewerecollectedforhistopathlogicalandimmunohistochemicalstudies.Immunohisto-chemistrywasusedtoanalyzetheexpressionofPPAR-γ,VCAM-1andICAM-1inthearterialvesselwall.ResultsComparedwiththecontrolgroup,thelevelofTC,TG,LDL-C,andBGinbloodwereincreasedsignificantly(P<0.01)intype2Diabeticgroup.ThetelmisartanandrosiglitazonetreatmentdecreasedbloodTC,TG,LDL-CandBG.TheexpressionofPPAR-γintype2diabeticgroup,telmisartanandrosiglitazonegroupshadsignificantdifferencescomparedwiththecontrolgroup,buttherewasn'tanysignificantdifferences(P>0.05)amongthosethreegroups.ExpressionofVCAM-1,ICAM-1andthemonocytesinfilitratingintotheintimaoftheaortastelmisartanandrosiglitazoregroupwassignificantlylowerthanthoseindiabeticgroup(P<0.01).Theendothelialdamageoftheaortaeintehnisartanandrosiglitazonegroupwaslessseverethanthatindiabetesmellitusgroup.ConclusionTelmisartanandrosiglitazonecanpreventearlyatherogenesisthroughalleviatingthedamagetothearterialwallbyincreasingtheactivationofPPAR-γandinhibitingtheVCAM-1,ICAM-1expressionandthemonocytesinfilitratingintothearterialwall.

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简介：Researchthataddressesmalere-productivehealthshouldassistinthedevelopmentofreproductivehealthprogrammaesandpolicy;identifyandtestnewleadsinnudecontraceptivetechnology;establisheffectivemaleinvolvementinitiativeswhicharelikelytohaveapositiveimpactonthereproductivehealthofmenandwomen;guidetheallocationofhealthcarereourcestoensurecost-effectivenessofinterventions;generatenewknowledge,developdiagnustictechnologyinreproductivehealthandofferoptimaltreatment/careregimens.InconsideringtheneedsanddemandsofnudereproductivehealthresearchinAsiaandthePacific,thefollowingsixresearchtopicsarerecommendedasthepriorityresearchareas:malecontraceptivetechnology;nudereproductivehealthbehaviourandmaleadolescentreproductivehealth;malereproductiveagingincludingmalemenopauseandotherdiseases;maleRTIs,STDs,HIV/AIDS;prevalence,managementandpreventionofnudeinfertility;environmentandsemenqualityandothermalereproductiveproblems.Oneofthemajorchallengesnowfacingusistheelaburationofacomprehensive,yetrealisticmalereproductivehealthresearchagendathatreflecttheneedsanddemandsofAsiandevelopingcountries.Tothisend,tomakeuseofaninterdisciplinaryapproachisofstrategicimportance.Themostcreativeinsightsandproductiveleadsarelikelytoemergefromaresearchteamthatisinteldisciplinaryespeciallyinthefieldofreproductivehealth.(AsianJAndrol1999Jun;1:13-20)

简介：Studiesdemonstrateadeclineinandrogenswithageandthisresultsintheandropause.Theobjectiveofthispaperistoreviewtheliteratureonhormonalchangesthatoccurintheagingmalesanddetermineifthereareassociationsbetweendecreasedtestosterone,dehydroepiandrosterone(DHEA)anddecreasedcognitivefunction.Trialsofandrogenreplacementanditsimpactoncognitivefunctionwillalsobeanalyzed.MethodofanalysiswillbebyathoroughsearchofarticlesonMEDLINE,theIntemetandmajorabstractdatabases.Resultsoftheauthor'sownresearchin302menoftheassociationofmemorylossasasymptomintheandropausewillbepresented.Inaddition,theauthorsopentrialoftestosteronereplacementinhypogonadicmenwithAlzheimer'sdiseasewillalsobepresented.Theresultsoftheauthor'strialwillbecomparedwithotherinvestigators.Highendogenoustestosteronelevelpredictedbetterperformanceonvisualspatialtestsinseveralstudies,butnotinallstudies.Likewise,testosteronereplacementinhypogonadicpatientsimprovedcognitivefunctionsinsomebutnotallstudies.Testosteronehasalsobeenshowntoimprovecognitivefunctionineugonadalmen.SeveralstudieshaveshownthatdeclinesinDHEAmaycontributetoAlzheimer'sdiseaseandtheresultsofdoubleblindstudieswithDHEAreplacementanditseffectoncognitionwillalsobepresented.Insummary,thereisstillnoconsensusthatandrogenreplacementisbeneficialincognitivedeclinebutthisoptionmayprovepromisinginsomepatients.

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简介：与女乳癌相比，男乳癌是稀罕疾病，并且在临床/病理学的特征和预后之间的关系争论，或甚至大部分未知。在这研究，我们从合用的男乳癌病人在天津医药大学癌症研究所和医院从1996年1月对待到2011年12月的109nonmetastatic用临床、病理学的数据执行了回顾的分析。木头等级测试证明那降低肿瘤舞台，没有淋巴节点参与，和积极雌激素/孕酮受体地位是没有疾病的幸存和外套的好预言者univariate分析上的幸存。然而，hormonotherapy仅仅是没有疾病的幸存，并且不全面幸存的一个好预兆的因素。另外，基于考克斯，比例的危险回归模型，仅仅淋巴节点参与，和雌激素/孕酮受体地位是multivariate分析上的统计上重要的预兆的因素。我们的结果证明尽管辅助全身的治疗在男乳癌广泛地被使用，病人和预后在最后几十年，淋巴节点参与，和雌激素/孕酮受体地位改善了仍然是最重要的预示的因素。有一种更大的样品尺寸的未来的多中心研究着急地被需要进一步理解男乳癌。

简介：SolublemalewormantigenofSchistosomajaponicurn(Sj)wasinvestigatedfordevelopmentofnewvaccinecandidate.SDS--PAGEandWesternblottingwereperformedtocomparethedifferencebetweensolubleantigensfromwormsofdifferentsex.MicevaccinationwiththetestingpurifiedproteinwasfollowedbySjcereariaechallengetodetecttheprotectiveeffectagainstSj.Sixteenbandswereseenforthesolublemalewormantigenand12forthefemaleworm.Inaddition,adistinctbandof44.6kDafromthemalewormantigenwasobserved,anditsantigenicitywasdemonstratedbyWesternblotting.This44.6kDaproteincouldinducesignificantwormandeggreductionrateinmice(39.31%,41.98%,P<0.001).Inthisstudya44.6kDaproteinwasisolatedandpartiallycharacterized.Itsantigenicity,immunogenicityandthepartialimmuneprotectionsuggestitspotentialvaccinecandidteagainstSj.

简介：ArtificiallyinducedtetraploidPacificoyster,CrassostreagigasThunberg,producesmoreaneuploidgametesthannormaldiploidone,althoughtheyshowedacomparablefecunditytodiploidy.Themeioticchromosomeconfigurationof3tetraploidand1tetraploid/triploidmosaicmaleswereanalyzedthroughdirectchromosomeobservation.AmajorityofmetaphaseIspermatocytescontainedbothbivalentsandquadrivalents.Thechromosomeconfigurationofthesemaleswascharacterizedbypreferentialformationofbivalentstoquadrivalents.Bivalentsappearedinallspermatocytesandconsistedof86%ofallchromosomeaggregates.Incomparison,quadrivalentsoccurredin91%spermatocytesandconsistedofonly12.6%ofallchromosomeaggregates.Themeanbivalentfrequencyperspermatocytevariedbetween14.4and17.2;whilethatofquadrivalentsvariedbetween2.2and2.7.Mostquadrivalentsweretandemlychained(58%)orcircled(39%).Thetotalnumberofchromosomeaggregatesperspermatocyterangedfrom13to20withanaverageof17.6;while18(16bivalentsand2quadrivalents)wasthemostfrequent.Univalentsandtrivalentsappearedinverylowfrequency.Aneuploid(hypotetraploid)spermatocyteswereobservedinalowfrequency.Thechromosomeconfigurationofinthemosaicindividualwassimilartothatoftetraploidindividuals.Thepercentageoftriploidspermatocytes(2%)ofthemosaicindividualwassignificantlylower(χ2=30,P<0.01)thanthatoftriploidcells(46%)initssomatictissue.

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简介：Theepidemiologyofbenignprostatichyperplasia(BPH)andmalelowerurinarytractsymptoms(LUTS)hasevolvedconsiderablyduringthepastseveralyears.ThetermLUTSdescribesadistinctphenotypeandallowsforabroadepidemiologicdescriptionofurinarysymptomsatapopulationlevel.Althoughitisbecomingthepreferredtermforstudyingurinarysymptomsinpopulations,LUTS

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