简介:Estrogendeficiencyhasbeenproposedasariskfactorforalveolarboneloss,butwhetherornotestrogenwillinflucencethebonerebuiltingprocessduringorthodontictoothmovementandwhatthemechanismsinvolvedremainunclear.Thepaperaimstoprovidenewinformationthatmayelucidatethemodulatoryeffectofestrogenonthebone-resorbingcytokinesRANKLanditsanti-resorptivefactorOPGsecrectedbyHPLFswhicharealreadyforce-stimulated.TheexpressionofOPGmRNAisrisingaftermechanicalloadingeitherwithorwithoutstimulatedbyestrogenbefore.ButHPDLcellsexposuredtoestrogenfor24hbeforeloadedtendtoexpressmoreOPGmRNA.Comparedwiththeno-estrogengroup,theinhibittrendofRANKLmRNAismuchmoreapparentinwith-estrogengroup.Moreover,estrogenandmechanicforcetime-dependentlyincreasedOPGexpressionandattenuatedtheRANKLexpression.
简介:Curcumin,adietaryphytochemical,exhibitsmultifunctionalnaturalproductwithregulatoryeffectsoninflammation.However,thepoorbioavailabilitylimitsitsclinicalapplications.Thus,wedesignedandsynthesizedanovelmonocarbonylanalogueofcurcuminB7andtheirinhibitionagainstmonocytechemotacticprotein-1(MCP-1)andinterleukin-8(IL-8)releasewasevaluatedinH2O2-stimulatedhumanvascularendothelialcells(ECs)inadose-responsivemanner,whileexhibitingnocytotoxicityinECs.Takentogether,theseinsightsonthenovelcompoundB7mayserveaspotentialagentsforthetreatmentofatherosclerosis.