简介：

简介：

简介：瞄准：与良性的职业人员静电干扰增生(BPH)在病人为职业人员静电干扰发炎程度和感染调查风险因素以便更高效地管理职业人员静电干扰发炎。方法：有在四川大学的韦斯特中国医院里经历在2005年9月和2005年12月之间的TURP的BPH的六十个病人被学习。前列腺液体(PF)为能分泌的IgA(SIgA)的测量被收集并且补充3(C3)。前列腺织物为由即时PCR的严峻的细菌的16SrDNA是镇定的，检验在织物的SIgA并且检验发炎。为职业人员静电干扰发炎或感染的可能的临床、有免疫力的风险因素被使用逻辑回归方法分析。结果：在尿分析法，职业人员静电干扰感染和在PF的C3的高集中的反常的白血房间计数是为职业人员静电干扰发炎程度的风险因素(P=0.025，0.034和0.035，分别地并且机会比率[或]=18.269，8.284和1.508，分别地)。为职业人员静电干扰感染的风险因素在PF包括C3集中和SIgA的集中(P=0.003和0.013，分别地并且OR=1.645并且0.993，分别地)。结论：现在的学习建议那职业人员静电干扰发炎与泌尿道感染，职业人员静电干扰感染和激活的补充被联系，那职业人员静电干扰感染与BPH在病人的前列腺与激活的补充并且在调整粘膜免疫下面被联系。单个有免疫力的规定应该与BPH在职业人员静电干扰发炎的治疗和病人的感染被考虑，这也被建议。

简介：Podophyllotoxone,4β-hydroxy-2,3-en-apopicropodophyllin,and4-deoxy-4β-azado-2,3-en-apo-picropodophyUincaneasilytransformto4-hydroxy-dehydropicropodophyUin,dehydroanhydropicropodophllyinand4-amino-dehydropicropodophyllinrespectivelyindifferentconditions.Thesepropertiesremind.ustobecarefulinhandlingrelatedcompoundsinsimilarconditions.

简介：我们决定了在prostatic演算和更低的尿道之间的关联症状(LUTS)，以及prostatic演算的预先安排的因素。为LUTS在我们的诊所介绍了的1527个病人，802经历了完全的评估，包括transrectalultrasonography，voidedbladder-3标本和国际prostatic症状分数(IPSS)。有prostatic演算的335个病人和没有prostatic演算的467个病人的一个总数分别地被划分成演算和没有演算组。严重LUTS和prostatic演算的预兆的因素用uni/multivariate分析被决定。全面IPSS分数是15.7卤9.2在演算和没有演算组织的9.2和14.1卤，分别地(P=0.013)。最大的流动率是12.1卤6.9和14.2卤8.2mLs?1在演算和没有演算组织，分别地(P=0.003)。在为预言严重LUTS的因素的univariate分析上，在年龄的差别(P=0.042)，prostatic演算(P=0.048)并且前列腺炎(P=0.018)是统计上重要的。在multivariate分析上，然而，没有因素是重要的。在为预先安排的multivariate分析上prostatic演算的因素，在年龄的差别(P<0.001)并且前列腺体积(P=0.001)是重要的。到我们的知识，有prostatic演算的病人抱怨更严重的LUTS。然而，prostatic演算不是严重LUTS的一个独立预兆的因素。因此，不仅因为prostatic演算而且因为年龄和另外的因素，有prostatic演算的人有更严重的LUTS。另外，老年和大前列腺体积是为prostatic演算的独立人士预先安排因素。

简介：主要睫的运动障碍(PCD)是源于正常睫的功能的损失的正染色体后退的混乱。症状包括新生的呼吸悲痛，长期的窦炎，bronchiectasis，地点inversus，和不孕。然而，仅仅15联系PCD的基因被识别了迄今为止引起男不孕。由于PCD的基因异质，全面分子的基因测试没被认为照顾的标准。这里，我们在与与男不孕联系的PCD有关的基因因素的鉴定上提供进步的更改，总结内在的分子的机制，并且讨论这些调查结果的临床的含意。这块地里的进一步的研究将为男不孕影响诊断策略，使临床医生能向病人提供通知基因建议，并且帮助为开发直接指向的个性化的药采用治疗的最好的功课。

简介：

简介：无

简介：探索临床的特征和风险因素的目的在受不了骨质疏松症相关的破裂以及有效干预的病人重新断裂。从2006年1月的方法到2008年1月，我们的医院里的门诊病人和住院病人是超过50岁并且受不了骨质疏松症相关的破裂的人，为这研究被选择。他们被划分成破裂组并且重新断裂组。重新断裂率被跟随在上面为2，年，11个病人在期间发展了重新断裂，因此在重新断裂组被包括。因此，273个病人，225个第一破裂的盒子，变老(67.7

简介：无

简介：Theetiologyofvasoplegicsyndrome(VS)isnotcompletelyelucidatedandtheclinicalimportanceremainsspeculative.MethodsTwenty-fourpatientswhounderwentcoronaryarterybypassgraftinganddevelopedVSwerecomparedwith48controlpatientswithoutVSina2:1casecontrolstudy.Casesandcontrolswerematchedbygender,age(±5yearsold)andoperationdate(±1week).ResultsTheindependentpredictorsofVSwerelowerejectionfraction(OR10.75,95%CI2.93-39.44,whenLVEF<0.45)anddiureticuse(OR8.98,95%CI2.59-31.10)inlogisticregressionanalysis.Conclusionlowerejectionfraction(<0.45)anddiureticuseareindependentriskfactorsforVSoccurrence.

简介：Therecognitionthatpsychosocialriskfactorscontributetothepathogenesisofcardiovasculardiseasehasledtothedevelopmentofanewfieldofbehavioralcardiology.Theinitialimpetusforthisfieldwasstudiesperformedinthe1980sand1990sthatprovidedepidemiologicalevidenceandapathophysiologicalbasisforastronglinkbetweenanumberofpsychosocialriskfactorsandcardiovasculardisease,includingdepression,anxiety,hostility,jobstress,andpoorsocialsupport.Inrecentyears,additionalpsychosocialriskfactorshavebeenidentified,includingpessimism;otherformsofchronicstress,suchaschildhoodabuseandtrauma,andthepsychologicalstressthatmaybeassociatedwithchronicmedicalillness;lackoflifepurpose;andthesyndromeof“vitalexhaustion,”whichconsistsofatriadofexhaustion,demoralization,andirritability.Newresearchinthelastdecadehasalsoestablishedthatpositivepsychosocialfactors,suchasoptimism,positiveemotions,avibrantsociallife,andastrongsenseoflifepurpose,canhaveanimportanthealth-bufferingeffectthroughtheirfavorableinfluenceonhealthbehaviorsandpromotionofpositivephysiologicalfunctioning.Patientscanbescreenedforpsychosocialriskfactorsinclinicalpracticethrougheithertheuseofopen-endedquestions,whichcanbeintegratedintoaphysician’sstandardreviewofsystems,ortheuseofshortquestionnaires.Physicianscanassistinthetreatmentofpsychosocialriskfactorsinvariousways,suchasscreeningpatientsforpsychologicaldistressandmakingappropriatereferralswhenindicated,providingpatientswithpracticallifestylesuggestions,andemployingofficepersonneltoteachpatientsbehavioralorpsychosocialinterventionsthatcanpromoteasenseofwell-beingand/orreducestress.

简介：Sex-specificdifferencesintheepidemiologyandpathophysiologyofcoronaryarterydiseaseandischemicheartdiseasearenowwellrecognized.Womenwithanginamoreoftenhavenonobstructivecoronaryarterydisease(NOCAD)comparedwithmen.Thispatientpopulationcarriesasignificantriskoffuturecardiovasculareventsthatisnotcommonlyappreciated,oftenleadingtodelayeddiagnosisandtreatment.WhilecoronarymicrovasculardysfunctionplaysacentralroleinthepathophysiologyofNOCADinwomen,othermechanismsofmyocardialischemiaarenowrecognized.RiskfactorssuchashypertensionandobesitydisparatelyaffectwomenandarelikelytoaccountforasignificantproportionofNOCADinthecomingyears.VascularinflammationisanimportantpathophysiologicpathwayinNOCADandisapotentialtherapeutictarget.CoronaryCTangiographyprovidesacomprehensiveassessmentofcoronaryanatomyandplaquemorphologyandisareasonablescreeningtestofchoiceforNOCAD.

简介：ThedefiningneuropathologicalfeatureofParkinson’sdisease(PD)isthelossofnigrostriataldopaminergic(DA)projections.Thisresultsinabiochemicalreductionofstriataldopaminelevelsandmovementdisorders,suchasatremoratrest,rigidityofthelimbs,bradykinesia,andposturalinstability(Kimetal.,2011;Kimetal.,2012;BurkeandO’Malley,2013;Leemetal.,2014;Nametal.,2014).BecausetheetiologyofPDisnotfullyunderstood,itcannotguidethedevelopmentofknowledge-basedtargetedtherapeutics.

简介：无

简介：AbstractBackground:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with loss of motor neurons. Our objective was to explore the epidemiology, clinical features, and survival factors of 1809 patients with ALS.Methods:We analyzed 1809 ALS patients, who were recruited from the Peking University Third Hospital from January 2005 to December 2015. Demographic data and disease-related parameters were collected. Kaplan-Meier curves were used to compare survival time. Cox proportional hazards function and the hazard ratio were used to identify adjusted prognostic predictors.Results:The results showed that the average annual incidence in Beijing alone was 0.38 cases/100,000 person-years and the mean age of onset was 48.88 ± 11.35 (95% confidence interval [CI]: 48.17-49.85) years. The median survival time from onset to death/tracheostomy was 58.89 ± 33.03 (95% CI: 51.46-63.84) months. In the adjusted Cox proportional hazard model, age of onset, diagnosis delay, rate of disease progression (Amyotrophic Lateral Sclerosis Functional Rating Scale Revised decline [points/month]), and body mass index all had an independent effect on survival in ALS.Conclusions:Our study provides information on epidemiology, clinical features, and survival factors of patients with ALS in China. These results can be helpful in clinical practice, clinical trial design, and validation of new tools to predict disease progression.

简介：无

简介：AbstractBackground:The aim of this study was to comprehensively evaluate the risk factors of periprocedural ischemic stroke associated with endovascular treatment of intracranial aneurysms using a real-world database.Methods:From August 2016 to March 2017, 167 patients were enrolled. Univariate analysis and multivariate logistic regression analysis were used to examine the risk factors for periprocedural ischemic stroke.Results:Among the 167 cases, periprocedural ischemic stroke occurred in 20 cases (11.98%). After univariate analysis, the ischemic group had a higher proportion of large (≥ 10 mm) aneurysms than the control group (45.0% vs. 23.1%, p= 0.036). The incidence of periprocedural ischemic stroke was higher in cases treated by flow diverter (21.6%) or stent-assisted coiling (11.8%) than in cases treated by coiling only (2.7%), and the differences were statistically significant (p = 0.043). After multivariate logistic regression analysis, treatment modality was the independent risk factor for periprocedural ischemic stroke. Compared with the coiling-only procedure, flow diverter therapy was associated with a significantly higher rate of periprocedural ischemic stroke (OR 9.931; 95% CI 1.174-84.038; p = 0.035).Conclusions:Aneurysm size and treatment modality were associated with periprocedural ischemic stroke. Larger aneurysms were associated with increased risk of periprocedural ischemic stroke. Flow diverter therapy was associated with significantly more periprocedural ischemic stroke than the coiling procedure alone.

简介：AbstractObjective:Endoscopic approaches for sinus and skull base surgery are increasing in popularity. The objective of this narrative review is to characterize risk factors for internal carotid artery injury in endoscopic endonasal surgery (EES), highlight preventative measures, and illustrate key management principles.Data Sources:Comprehensive literature review.Methods:Relevant literature was reviewed using PubMed/MEDLINE.Results:Carotid artery injury in EES is rare, with most studies reporting an incidence below 0.1%. Anatomic aberrancies, wide dissection margins, as well as specific provider and hospital factors, may increase the risk of injury. Multidisciplinary teams, comprehensive preoperative imaging, patient risk assessment, and formal training in vascular emergencies may reduce the risk. Management protocols should emphasize proper visualization of the injury site, fluid replacement, rapid packing, angiography, and endovascular techniques to achieve hemostasis.Conclusions:While EES is a relatively safe procedure, carotid artery injury is a devastating complication that warrants full consideration in surgical planning. Important preventative measures include identifying patients with notable risk factors and obtaining preoperative imaging. Multidisciplinary teams and management protocols are ultimately necessary to reduce morbidity and mortality.

简介：无