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简介：Angiogenesisintheinfarctperipherycanimprovebloodflow.Vascularendothelialgrowthfactor(VEGF)hasbeenconsideredapotentialtherapeutictargetforstroke.BuyangHuanwudecoction(BYHWD)isaclassictraditionalformulaintraditionalChinesemedicineandisusedtotreatstroke;inaddition,thepromotioneffectsonVEGFproteinexpressionhavebeenconfirmed.However,littleisknownabouthowBYHWDregulatesangiogenesis,orabouttheeffectsofBYHWDonVEGFmRNAexpression.Forthisreason,thepresentstudymeasuredmicrovesseldensityinratswithcerebralischemiausingimmunohistochemistry.Inaddition,VEGFexpressionwasmeasuredbyreverse-transcriptionpolymerasechainreactionandenzyme-linkedimmunosorbentassaytode-terminetheeffectsofBYHWDonangiogenesisandVEGFexpressioninratswithcerebralischemia.Resultsdemonstratedthatmicrovesseldensity,aswellasVEGFmRNAandproteinexpression,increasedafter7and14daysofBYHWDtreatment,whichsuggeststhatBYHWDpromotedan-giogenesisfollowingcerebralischemiaandupregulatedVEGFmRNAandproteinexpressioninischemiccerebralregions.

简介：Aratmodelofextra-vertebralforamencervicalnerveentrapmentwasestablishedaccordingtothefollowingparameters:stimulationintensity20V;frequency50Hz;pulsewidth200μs;duration333ms/sforatotalof8hours.Aftertheelectricalstimulation,ratsexhibitedmildmusclefiberatrophy,mildinflammatoryexudates,connectivetissuelocalfibrosisandchondrocytemetaplasia.Meanmusclefibercross-sectionalareawasreduced.Thenervemyelinsheathcontinuitywaspartiallydemyelinated.Themicrostructureofnervecellswasdisruptedandthesesymptomsworsenedwithprolongationofthestimulation.Theshoulder,neckandupperextremitymusclesonthetestedsidedemonstratedpositivesharpwavesandfibrillations.Theseverityincreasedwithcontinuationofthestimulation.Highamplitudeandpolyphasicmotorunitpotentialsgraduallyappeared.Similarfindingswereseeninthecontralateralside,butatalessseverelevel.