简介：为semilinear的起始边界的值问题的答案的空间腐烂在易于侧面的边界上的零个条件的可变剖面图的半无限的柱体的寓言的方程被调查。秒顺序显示出空间腐烂O的微分不平等(exp(z2/(4(t+t0))))为L2p，答案的代表性的措施被获得。导致生长或腐烂的一阶的微分不平等也被导出。在生长的情况中，为在空间的发作的上面的界限被获得，当在腐烂的情况中为全部的精力的上面的界限以数据被获得时。

简介：转变生长因素贝它(发信号的TGF-尾)/bonemorphogenic蛋白质(BMP)涉及绝大多数细胞的过程并且在所有metazoans的全部生活期间是根本上重要的。TGF-尾/BMP活动的解除管制几乎总是导致发展缺点或疾病，包括癌症。TGF-尾/BMP小径的合适的工作与另外的发信号的小径取决于它的组成、广泛的通讯，导致synergistic或对抗效果和最后理想的生物结果。如此的发信号的串音的性质是压倒性地复杂的并且高度上下文依赖者。这里，我们考察在TGF-尾/BMP和激活Mitogen的蛋白质kinase，phosphatidylinositol-3kinase/Akt，Wnt，刺猬，槽口，和interleukin/interferon-gamma/tumor坏死factor-alpha的发信号的小径之间的串音的不同模式cytokines，与内在的分子的机制上的一个重音。

简介：RhoGTPases是作为许多的关键管理者扮演细胞的进程的分子的开关，包括房间运动，形态发生，主机防卫，房间部门和基因表示。RhoGTPases在所有真核细胞的王国被发现。植物缺乏清楚的相当或相同的事物到在酵母和动物发现的常规RhoGTPases；相反，他们随着时间的过去开发了一个唯一的亚科，ROP，是也知道皇家装甲兵。象ROP一样蛋白质的起源看起来先于陆地植物的外观。这评论试图讨论ROP/RAC的进化并且比较植物ROP和动物RhoGTPases，集中于GTPases和他们的下游的受动器的规定的类似和差别。

简介：Monoclonal(mAb)成功地被用于长期的疾病的治疗，例如癌症，发炎和有免疫力的疾病。与在抗体工程的技术进展，当有减少的immunogenicity的高亲密关系治疗学在聚光灯下面变得，小重组体抗体的开发碎裂。设计重组体抗体碎片的一种流行格式是单个链的改正变量(scFv)分子，父母抗体的VH和VL区域被一个多肽连接器一起在连接。scFv碎片保留目标特性和未经触动的抗体，和罐头的抗原绑定亲密关系被在房间从单个cDNA表示VH和VL区域的宫外的联盟者遗传上在大数量设计并且生产。由于它的更小的尺寸，scFv分子表演在肿瘤穿入改进了pharmacokinetics并且被主人免疫系统更好容忍。

简介：为粒子形态学和对使流体化床的动力学的描述的球状和Zingg因素的比较被介绍。它被发现那Zingg因素Fz=LH/B2(在分别地，L，H和B是一个粒子的长度，宽度和高度的地方)很好描述粒子形态学的效果。试验性的结果证明非球形的粒子给以压力落下同样与球形的粒子相比优秀的使流体化的穷人，Umf，等等。与一样的卷等价物直径，非球形的粒子有更低的Umf和使流体化的系数。一些光滑的曲线在参数，Umf和Fz之间被获得了。使液化的质量能被使流体化评估系数，它在这份报纸被相关到Zingg因素和最小的使流体化速度。

简介：抽象本地配偶比赛理论在传花粉给预言那后代性比率微量黄蜂当仅仅有一个女创立者时，是偏导女性的，并且在增加的后代性增加女创立者密度结果比率。另外的女创立者和离合器尺寸的信息被建议了是对在本地配偶竞争下面的性比率调整的主要贴近的解释。我们的焦点是在一只传花粉给的微量黄蜂显示出性比率调整的机制，CeratosolensolmsiMayr，机能上地雌雄异体的微量的obligatepollinator，Ficushispida悬崖，与这块地里的控制实验。首先，我们在不同oviposition序列从一pollinator和后代获得了后代，并且发现那后代性比率与离合器尺寸减少了，并且pollinators在一回的开始生产了大多数他们的男后代，列在后面由主要女性。第二，我们发现那后代性比率与女创立者密度增加了，并且pollinators做了在oviposition补丁以另外的女性调整他们的后代性比率。我们建议当oviposition地点是不有限的时，pollinators将主要以离合器尺寸变化的另外的女创立者独立人士调整他们的后代性比率，而当oviposition地点是有限的时，调整离合器尺寸可以被用来调整性比率。

简介：BACKGROUND:Previousstudiesreportedthatfrontal-temporal-parietal-occipitalpathologicalchangesanddiseasedrangeintherightcerbralhemispherewerecorrelatedwithneglect.Butstudiesonthecorrelationofneglectwithdiseasedregionandareainpatientswhosufferfrominitialattackofsinglefocusofcerebralinfarction(CI)inleftandrightcerebralhemispheresarefew.OBJECTIVE:ToobservethestatusofneglectinpatientswhosufferfromsinglefocusofCIincerebralhemisphereandanalyzethecorrelationofneglectwithdiseasedregionandareaofCI.DESIGN:CaseanalysisSETTING:TreatmentCenterforCardiocerebrovascularDisease,SecondHospitalofXiamencity;DepartmentofNeurology,FirstHospitalAffiliatedtoBaotouMedicalCollege.PARTICIPANTS:AlltheCIpatientshospitalizedintheDepartmentofNeurology.FirstHospitalAffiliatedtoBaotouMedicalCollegefromJune1998toMay2001wereretrieved.Inclusivecriteria:①PatientswhosufferedfrominitialattackofCI.whichwasconfirmedbyskullCTorMRIwithin24hoursafteronsetandpresentedsinglefocusincerebralhemisphere.②beconsciousandcouldcooperateintheexamination.③didnotreceiveformaleducation,butcoulddoaccountsandsomesimplewritingandreading.④Patientswithhomonymoushemianopiawereexcludedthroughtheexaminationofperimeter.⑤Informedconsentswereobtainedfromallthepatients.Among67patientswhomettheinclusivecriteria.33sufferedfromCIintheleftcerebralhemisphereand34intherightcerebralhemisphere.METHODS:①PatientsreceivedneglectsupplementexaminationandChineseaphasiaexaminationwithin2.5to3monthsaftertheattackofCI.Thediagnosticcriteriaofneglectinthetestsoflinecancellation.1inebisectionandcopyingthefigureswereasfollows:InthelinecancellationtestbasedonthemethodofAlbert.patientswhocouldnotcanceloneormorelineswereregardedasabnormal.InthelinebisectiontestbasedonthemethodofPeter.patientswholeftdeviated1.16%

简介：China'srelationswithotherdevelopingcountries,animportantcomponentpartandthefoundationofitsforeignpolicy,comprisestwomajordimensions

简介：Researchshowsthatthemortalityrateamongpeoplewithschizophreniaisuptofourtimeshigherthanthatinthegeneralpopulation.Thesubsequenthighcomorbiditiesandsocietalcostofschizophrenianecessitatefindingbetter,moreeffectivetreatmentsandstrategiesforprevention.Oneofthecurrentobstaclesarethecomplicatedgeneetiologiesthatareinvolvedinthepathophyslologyofschizophrenia.Sofar,anincreasingnumberofclinicalandexperimentalstudiesshowlinksbetweenschizophreniatreatmentandgeneticconditions.Here,weanalyzetheliteratureonschizophreniagenetics,withaparticularfocusonthebrain,themindandenvironmentalinsults.Anoverlapofschlzophrenlawithotherpsychoticdisordershasalsobeentakenintoaccuntwithanattempttofindaparallelrelationshipbetweengeneticsandtreatment.Finally,wesummarizeallthepresent-daytreatmentoptionsforschizophrenialikeclozapineandelectroconvulslvetherapyandalsotakeintoconsiderationtherelativelyunexploredroleoftraditionalChinesemedicine.

简介：在apoptotic小径以内的缺点在前列腺癌症(PCa)被含有tumorigenesis，变形前进和治疗抵抗。癌症的一个特点是出轨的能力由禁止apoptotic信号，减少apoptotic蛋白质的表达式或放大幸存的apoptosis通过antiapoptotic的增加的生产发信号分子。这评论描述在热吃惊蛋白质(HSP)和人的雄激素之间的协会受体(AR)，HSP的角色和在PCa开发的另外的导致压力的蛋白质和在指向这些保护的蛋白质对待PCa的新兴的策略。

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简介：在北半球从14个地点把重建和代理数据基于温度，这篇论文集中了于比较在北极和另外的区域之间的温度变化的周期包括大西洋，欧洲，中国，亚洲，和平，印度洋，并且美洲在到最后冰川的最大值的从最后Interstade的转变期间，从最后冰川的最大值到在Holocene和由单个光谱分析(SSA)的方法的小冰川期(LIA)的转变的megathermal时期结果证明在北极的环境变化在北美人并且更好很类似于那类似于亚洲，大西洋和太平洋，最不类似于印度洋和欧洲。温度的1500年的摆动在北极和欧洲两个都存在。

简介：一个单身者(对方的独立人士)有对正弦电场的波动的潜在的障碍和题目的蛋白质马达系统被调查。我们首先与波动的潜在的障碍导出这个系统的近似Langevin方程。然后从这个近似Langevin方程，我们在断热的限制计算signal-to-noise比率(SNR)。随机的回声的现象被作出对有利的裁决有波动的潜力的这个蛋白质马达系统障碍。

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简介：ＥＸＰＥＲＩＥＮＣＥＳＯＦＴＨＥＯＰＥＮＩＮＧ－ＵＰＡＮＤＥＸＰＬＯＩＴＡＴＩＯＮＯＦＶＡＲＩＯＵＳＩＮＴＥＲＩＯＲＲＥＧＩＯＮＳＢＹＩＮＤＩＡ，ＰＡＫＩＳＴＡＮＡＮＤＯＴＨＥＲＣＯＵＮＴＲＩＥＳＨｅＤａｏ－ｌｏｎｇ；ＬｉｕＸｉａｏ－ｆｅｎｇａｎｄＸ...

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简介：Intheefforttodevelopacomprehensiveapproachtobetterandgoodjobs,itisatopicofhotdebateastowhethertheintroduction(temporarilyoronapermanentbasis)ofstatutorylegislation―differentfromthegenerallawapplyingtosubordinateworkers―mayencourageemployersandemployeestooperatewithintheformaleconomyandinthecontextofregularcontractsofemployment.Theessayanalyzesfromacomparativepointofviewnotthetraditionalformsofnon-standardemployment,butthosespecialworkingarrangements,thatmayinvolveveryshorthours(“marginal”parttime:generally,fewerthan15hoursperweek)ornopredictablefixedhours,andthoseaccordingtowhichtheemployerhasnoobligationtoprovideasetnumberofhoursofwork.Theconclusionisthatextremelyatypicalformsofworkappeartogiveananswertothechallengesofthemarketlaboroftheurbaneconomiesofthe21stcentury,butthatspeciallegalprovisionsareneededtoguaranteeindividualrighttofairwagesandtoprotectpersonallifeofemployees.

简介：MutationsintheGJB2genearethemostfrequentlyfoundmutationsinpatientswithnonsyndromichearingimpairment.However,themutationspectrumandprevalenceofmutationsvaryamongdifferentethnicgroups.Everyyear,30,000babiesarebornwithcongenitalhearingimpairmentinChina.Inordertoprovideappropriategenetictestingandcounselingtothefamily,weinvestigatedthemolecularetiologyofnonsyndromicdeafnessin135unrelatedschoolchildrenattendingChifengMunicipalSpecialEducationSchoolinInnerMongolia,China.ThecodingexonoftheGJB2genewasPCRamplifiedandsequenced.Inaddition,the12SrRNAgeneandtRNAser(UCN)ofmitochondrialgenomewerescreenedformutationsresponsibleforhearingimpairment.SixtyfourGJB2mutantalleles,including60confirmedpathogenicallelesand4unclassifiedvariants,wereidentifiedin31.1%(42/135)ofthesubjects.Twentytwosubjectscarriedtwopathogenicmutationsand20subjectscarriedonemutantallele,includingonesubjectwithoneautosomaldominantmutation.The235delCwasthemostcommonmutationaccountingfor65.6%(42/64)GJB2mutantalleles.WhencomparedtootherAsianpopulations,oursubjectcohorthadhigherfrequencyof235delCmutationthantheJapanesepopulation.TheGJB2mutantallelesaccountfor23.7%(64/270)ofallchromosomesresponsiblefornonsyndromichearingimpairment.Testingofthe4mostprevalentdeleteriousframeshiftmutations(235delC,299_300delAT,176_191del16,and560_605ins46)inthiscohortdetected90%ofallGJB2mutantalleles.TheseresultsdemonstratethateffectivegenetictestingoftheGJB2geneforpatientsandfamilieswithnonsyndromichearingimpairmentispossibleintheChinesepopulation.Sincethemostcommon309kbGJB6deletionisnotdetectedandonlyone1555A>GmutationinmitochondrialDNAisdetectedinourpatients,investigationofmutationsinothernucleargenesand/orenvironmentalfactorsresponsiblefornonsyndromichearingimpairmentintheChinesepopulationis

简介：SystematicgeochemicalstudiesoftheProterozoicLengjiaxiGroupinnortheasternHunanProvincesuggestthattheLengjiaxiGroupisaAu-As-Sb-Wassociation-typeAu-bearingturbiditeformation.ThecontentsofAu,As,Sb,W,Cr,Mn,PbandZnintheturbiditeformationaremorethantwotimesashighastheaveragecontentsoftraceelementsintheuppercontinentalcrust.ThelowabundanceofAgandtheclosecorrelationbetweenAuandAsaretwoimportantcharacteristicfeatures.IntheAu-bearingturbiditeformationtheenrichmentofgoldisduetotheextensiveoccurrenceofAu-bearingpyrites.HighercontentsofAu,W,SbandAginthegreywackeindicatethattheyalsoexistintheformofheavyminerals.Au,Ag,As,Sb,WandREEintheAu-bearingturbiditeformationhaveaclosegeneticrelationwiththechemistryofthegolddeposits.