简介:0引言急性后部多灶性鳞状色素上皮病变(acuteposteriormultifocalplacoidpigmentepitheliopathy,APMPPE)由Gass于1968年首先报道。本病发病急,目前临床并不多见。本文报道1例双眼急性后部多灶性鳞状色素上皮病变的病例,就其发病原因、病情演变及治疗、愈后进行简要的分析总结。
简介:患者女,57岁,无青光眼病史.因"右眼视物不清20余天"入院,23d前在外院全身麻醉下行"心脏冠状动脉搭桥术",术前给予阿托品0.5mg,鲁米那100mg.术后第一天感右眼视物模糊伴疼痛不适.诊断为"右眼急性闭角型青光眼"入院查体;视力右0.4,左0.8,眼压:右32mmHg,左13mmHg,(1mmHg=0.133kPa),双眼角膜尚透明,前房略浅,瞳孔中度大,对光反射消失,前房角镜下见房角NⅢ~Ⅳ,晶状体轻度混浊,右眼晶状体后囊下见青光眼斑,双眼C/D≈0.5.诊断为"双眼闭角型青光眼".在局部麻醉下行右眼巩膜分层咬切术后,眼压10~13mmHg,病情稳定,左眼择期行激光虹膜周切术.
简介:·AIM:ToexploretheimmunomodulatoryeffectsofcurdlanoninnateimmuneresponsesagainstAspergillusfumigatus(A.fumigatus)inculturedhumancornealepithelialcells(HCECs),andwhetherC-typelectinreceptorDectin-1mediatestheimmunomodulatoryeffectsofcurdlan.·METHODS:TheHCECswerestimulatedbycurdlanindifferentconcentrations(50,100,200,400μg/mL)forvarioustime.ThenHCECspretreatedwithorwithoutlaminarin(Dectin-1blocker,0.3mg/mL)andcurdlanwerestimulatedbyA.fumigatushyphae.ThemRNAandproteinproductionoftumornecrosisfactor-α(TNF-α)andinterleukin-6(IL-6)weredeterminedbyreal-timequantitativepolymerasechainreactionandenzyme-linkedimmunosorbentassay,respectively.TheproteinlevelofDectin-1wasmeasuredbyWesternblot.·RESULTS:CurdlanstimulatedmRNAexpressionofTNF-αandIL-6inadoseandtimedependentmannerinHCECs.CurdlanpretreatmentbeforeA.fumigatushyphaestimulationsignificantlyenhancedtheexpressionofTNF-αandIL-6atmRNAandproteinlevelscomparedwithA.fumigatushyphaestimulationgroup(P<0.05).BothcurdlanandA.fumigatushyphaeup-regulatedDectin-1proteinexpressioninHCECs,andDectin-1expressionwaselevatedto1.5-to2-foldbycurdlanpretreatmentfollowedhyphaestimulation.TheDectin-1blockerlaminarinsuppressedthemRNAexpressionandproteinproductionofTNF-αandIL-6inducedbycurdlanandhyphae(P<0.05).·CONCLUSION:ThesefindingsdemonstratedthatcurdlanpretreatmentenhancedtheinflammatoryresponseinducedbyA.fumigatushyphaeinHCECs.Dectin-1isessentialfortheimmunomodulatoryeffectsofcurdlan.Curdlanmayhavehighclinicalapplicationvaluesinfungalkeratitistreatment.
简介:患者男性,20岁,于2008年7月在我院行准分子激光原位角膜磨镶术手术.术前查屈光度:右眼-4.75DS-0.75DC×16°→1.0;左眼-5.0DS-0.5DC×159°→1.0.角膜厚度:右眼575μm,左眼582μm.角膜曲率:右眼K140.5D,K239.4D,左眼K140.9D,K240.3D.手术使用博士伦Z217型准分子激光治疗仪,采用Hansatome角膜板层刀制作角膜瓣,角膜瓣厚度110μm,蒂位于角膜上方,患者手术一切顺利,无游离角膜瓣及其他瓣的并发症.
简介:Nd:YAG激光是一项简易有效的后发性白内障治疗手段,人们对于其各类并发症也有了系统的认识和研究。但Nd:YAG激光治疗后发性自内障导致黄斑裂孔这一并发症临床十分罕见,现将我院Nd:YAG激光治疗后发性白内障导致黄斑裂孔1例报告如下。
简介:AIMTo在透镜调查Aquaporin-1(AQP-1)的角色上皮的房间(LEC)和它的潜在的目标基因。AQP-1明确地在眼睛的LEC被表示并且为透镜动态平衡和透明性维护是重要的。此处,在LEC的AQP-1表示被调查在奔流formation.METHODSLECs与它的潜在的角色联合在房间幸存上评估它的影响是有带AQP-1的lentivirus的transfected小介入RNA(siRNA)。实时聚合酶链反应(PCR)并且西方的弄污被进行从不同的组在LEC检测AQP-1表示。同时,房间数kit-8(CCK-8)试金和流动cytometry被执行测量LEC增长和apoptosis,respectively.RESULTSAQP-1表示显著地在LEC被减少,两个都在mRNA和蛋白质铺平(P<;0.05),在siRNA处理以后。减少的房间生存能力被CCK-8试金与siRNA干扰在LEC检测,与控制房间相比(P<;0.05)。apoptosis率显著地在siRNA干扰以后在房间增加了(P<;0.05).CONCLUSIONThe减少了在规定下面的房间生存能力追随者AQP-1大部分由于它LEC的apoptosis的正式就职。AQP-1减小可能在LEC导致生理的功能的变化,它可能与奔流的出现和发展被联系。
简介:·AIM:Toobtainwideningofapotentiallyoccludableangle,inaccordingtoKanski’sindications,throughpreventiveNd:Yaglaseriridotomy.Theobservationalstudywasperformedbyusinggonioscopyfortheselectionandfollow-upof1165treatedeyesandexploitingShaffer-Etiennegonioscopicclassificationasaquality/quantitytestoftheanglerecession.·METHODS:BetweenSeptember2000andJuly2012,586patientswereselectedattheOutpatients’OphthalmologicalClinicofthePoliclinicoUmbertoIofRomeinordertoundergoNd:Yaglaseriridotomy.AGoldmanntypecontactlens,Q-switchedmode,2-3defocus,and7-9mJintensitywith2-3impulsedischargeswereusedforsurgery.·RESULTS:Fromasearlyasthefirstweek,awhole360°anglewideningwereevidentinthepatients,thusshowingthesuccessofNd:Yaglaseriridotomyinsolvingrelativepupilblock.Theangleremainednarrowby270°in14eyesonly,despiterepetitionsoffurthertreatmentwithlaseriridotomyinadifferentpartoftheiris,twicein10eyesandthreetimesin4eyes.·CONCLUSION:Nd:YaglaseriridotomyrevealeditselfasbeingasafeandeffectivetreatmentinwideningthosecriticalShaffer-Etiennegrade1and2potentiallyoccludableangles.