简介:Detainees’rightsinpre-trialdetentionhousesareameansofassessingacountry’shumanrightsprotection.Asalegalfacilityforcarryingoutcriminaldetention,apre-trialdetentionhouseshouldremainneutralandsafeguarddetainees’substantiveandproceduralrights.Itshouldbeanimportantbaseforthecountrytorespectandprotecthumanrights.Atthemacrolevel,protectingdetainees’rightscomprisestwoaspects:1)proceduralrights,regardingwhichtheprincipleofpresumptionofinnocenceshouldbeapplied;and2)detaineetreatment,regardingwhichtheprincipleofsocializationshouldbeapplied.AtthecurrentstageofChina’srightsprotectionsituation,Chinashouldimprovedetainees’rights,suchastherighttohaveanindividualbed,therightstohealthcareandreligiousfreedom,rulesregardingtheuseoflegirons,andtransparencyandindependentmonitoringmechanisms.
简介:系在的系统为钻在的半能沉入水中的钻塔起一个重要作用深海。详细分析在进行了很好在2009在华南海在一个深海的地点钻的试用的一个半能沉入水中的钻塔的绳索上被执行。钻塔是30岁并且与457m的设计的最大的操作的水深度有一个浅平台。后面的系在分析,一个系在的图案被给那要求钻塔原版绳索系统升级。升级包括了几革新,例如安装八个更大的锚,即代替原来的锚并且插入一另外有存在的链的钢电线的600m。所有这些被做为在职务要保持进行在476m的水深度钻的钻塔提高钻塔的系在的能力。钻的全面持续时间是50天和证明在当它在华南海正在钻试用很好时,达到使钻塔静止的目标有效的升级的绳索系统。这个成功的运动证明一个更旧的半能沉入水中的钻塔能雇用在小心的设计并且到原来的绳索系统的合适的升级和修正以后在深水里钻。
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简介:AbstractAlthough whole-exome sequencing and whole-genome sequencing has tremendously improved our understanding of the genetic etiology of human disorders, about half of the patients still do not receive a molecular diagnosis. The high fraction of variants with uncertain significance and the challenges of interpretation of noncoding variants have urged scientists to implement RNA sequencing (RNA-seq) in the diagnostic approach as a high throughput assay to complement genomic data with functional evidence. RNA-seq data can be used to identify aberrantly spliced genes, detect allele-specific expression, and identify gene expression outliers. Amongst eight studies utilizing RNA-seq, a mean diagnostic uplift of 15% has been reported. Here, we provide an overview of how RNA-seq has been implemented to aid in identifying the causal variants of Mendelian disorders.
简介:Inheritedcardiomyopathiesaremajorcausesofmorbidityandmortalityandincludeagroupofcardiacdisorderssuchashypertrophiccardiomyopathy(HCM),dilatedcardiomyopathy,arrhythmogenicrightventriculardysplasia/cardiomyopathy(ARVD/C),leftventricularnoncompaction(LVNC),andrestrictivecardiomyopathy(RCM).Thesediseaseshaveasubstantialgeneticcomponentandpredisposetosuddencardiacdeath.Sincethefirstgenewasidentifiedasadisease-causinggeneforHCMovertwodecadesago,morethaneightygeneshavebeenidentifiedtobeassociatedwithinheritedcardiomyopathiesandgenetictestinghasbecomeprevalentinmakingclinicaldiagnosis.Withtheadventofnext-generationsequencingtechnology,geneticpaneltestingofinheritedcardiomyopathieshasbecomefeasibleandcostefficient.Inthisreview,wesummarizetheindividualcardiomyopathieswiththeemphasisoncardiomyopathygeneticsandgenetictesting.
简介:Arthritisreferstotheinflammationofthejointscausedbyvariouskindsofetiologies.Clin-ically,therearerheumaticarthritis,rheumatoidarthritis,goutyarthritisandosteoarthritis.Arthritisistermed"BiSyndrome"intradi-tionalChinesemedicine."Bi",inChinese,means"stagnation"or"obstruction".Tradition-alChinesemedicineholdsthatBisyndromere-sultsfromtheinvasionofpathogenicwind,coldanddampness,orwind,coldandheat.Upontheinvasion,thesepathogenswillcauseobstruc-
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简介:Wehaveintroducedtheglousesupporter(GS)formicrosurgerysince1991andreporteditsexperimentalstudiesin1992,andnowwepresentitsresultsonclinicalapplicationsinthispaper.GSismadefromglucose,sodiumchlorideanddextranuminproperratio.Ithasbeenprovedtohavenomaterialtoxicityonanimalsandhuman
简介:42caseswithischialgiaweredividedintotwogroupsatrandom,inwhich30casesweretreatedbyacupuncture,12casestreatedbyChineseherbs.TheresultshowedthatacupuncturetherapywasmormeffectivethantheChineseherbs.Theexperimentalstudyindicatedthattheconcentrationofperipheralplasma5-HTwasmarkedlyhigherthannormalvaluebeforeacupuncturetreatment,whereasitsconcentrationdeclinedsignificantlyaftertreatment.(P<0.05)