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简介：Objective:Thisstudyaimedtodetermineifgastriccardiaadenocarcinoma(GCA)riskwasassociatedwiththelys(Aor*2)alleleatthers671(glu504lys)polymorphismwithinthealdehydedehydrogenase2(ALDH2)geneinaChineseHanpopulation.WealsoaimedtoinvestigateALDH2genotypicdistributionsbetweensubjectsfromhigh-andlow-incidenceareasforbothGCAandesophagealsquamouscellcarcinoma(ESCC).Methods:Wedesignedacase-controlstudyincluding2,686patientswithGCAand3,675controlsubjectsfromhigh-andlowincidenceareasforbothGCAandESCCinChina.TaqManallelediscriminationassaywasusedtogenotypethers671polymorphism.χ~2testandbinarylogisticregressionanalysiswereusedtoestimatetheoddsratiosforthedevelopmentofGCA,andmultivariateordinallogisticregressionwasusedtoanalyzeALDH2genotypicdistributionsamongdifferentgroups.Results:ComparedwithALDH2*1/*1homozygotes,ALDH2*1/*2andALDH2*2/*2carriersdidnotincreasetheriskforGCAintheChineseHanpopulation(P>0.05).Interestingly,theratioofhomozygousorheterozygousALDH2*2carriersinhighincidenceareasforbothGCAandESCCwaslowerthanthatinlow-incidenceareas(P<0.001).Conclusions:Genotypesofrs671atALDH2maynotincreaseGCAsusceptibilityinChineseHanpopulations.Inaddition,theALDH2genotypicdistributiondiffersbetweenChineseHanpopulationsfromhigh-andlow-incidenceareasforbothGCAandESCC.OurfindingsmayshedlightonthepossiblegeneticmechanismforthedramaticgeographicdifferencesofGCAoccurrenceinChina.

简介：AbstractPurpose:Severe damage to the femoral head in patients with osteonecrosis has a high impact on morbidity. Despite early diagnosis, the treatment outcome is still unsatisfactory. This study aimed to explore the expression of vascular endothelial growth factor (VEGF) and cyclic guanine monophosphate (cGMP) serum level as the risk factors of femoral head osteonecrosis in alcohol-exposed Wistar rats.Methods:This was an experimental study using randomized post-test only control group design, with samples using 10-14 weeks Wistar male rats. Rats were then divided into 6 groups: 3 groups without intervention, and 3 groups with intervention using 40% alcohol given perorally. Each one group from intervention and control group was euthanized by the end of the week for 3 consecutive weeks. Proximal femurs were examined under microscope for osteonecrosis, immunohistochemically for VEGF, and blood serum for cGMP levels.Results:VEGF expression in the femoral head of alcohol-exposed Wistar rats was lower than those not exposed to alcohol (p < 0.005). Blood serum cGMP levels of alcohol-exposed Wistar rats were higher than those not exposed to alcohol (p < 0.005). The number of necrotic osteocytes in the femoral head of Wistar rats exposed to alcohol was greater than those not exposed to alcohol (p < 0.005). There are significant differences between VEGF, cGMP levels, and number of necrotic osteocytes in the control group and treatment at 1st, 2nd, and 3rd week (p < 0.005).Conclusions:Based on the result of this study, VEGF and cGMP may be considered as diagnostic biomarkers for alcohol-induced femoral head osteonecrosis.

简介：Themountainousareas(mountain,plateauandhillyarea)covermorethan85%ofthetotallandterritoryofChina.Natureandhumanityinverymountainousareahasitsowngeographiccharacteristics.IntheprocessofindustrializationandurbanizationinChina,realizingthesustainabledevelopmentofthemountainousareas,optimizingman-landsystem,andadoptingandcontinuouslydevelopingcorrespondingeconomicmodesofthemountainousareaswithmulti-functionsofeconomy,ecology,cultureandsocietytocharacterizeproductioncontent,modeofproduction,modeofoperationisnotonlyhelpfultoeconomy,societyandecologicalvalueandisofgreataestheticvalue,butalsosolvethetechnologicalproblemsofthesubjectofstartingundertakingtofinallytransformtheregionalresourceadvantageofthemountainousareaintotheadvantageofcapitalandtechnologyforeconomicdevelopmentandtogetridofthecontradictionbetweenunderdevelopedeconomyandabundantresources.ThispapertakestheThreeGorgesReservoir(TGR)areaforexampletoshowthatit'sofgreatpracticalandtheoreticalsignificancetodevelop'FiveTypesofAgriculture'andtooptimizeecoenvironment,industrialstructure,departmentstructure,regionaldistribution,varietystructureandqualitystructure.

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简介：作为一个公事包管理工程的积极影响被比较一个工程公事包的综合风险和独立实现的单个工程风险的聚集的价值确定。第一，综合风险被基于集合理论建议危险事件定义。第二，在一个工程公事包与对方一起作为工程交往，综合风险被使用一个贝叶斯的网络评估构造风险的一个相互依赖的网络的结构学习算法。最后，一个实际盒子的综合风险用这个方法被估计，并且结果证明建议方法是为计算实现一个工程公事包并且识别的风险减小的程度的一个有效工具最危险工程，以便在在控制的公事包选择和公事包的阶段做全面决定帮助公司。

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简介：Intheprocessofperformanceofthesalescontract,thesubjectmatterisnotcausedbythecauseofbothpartiesandtheloss,andthatdamageshouldbebornebywhichpartyinthecontractisinvolvedinthesalescontractriskburden.Itisrelatedtothefundamentalinterestsofbothbuyersandsellers.Therefore,thisissuehasbecomeamatterofgreatconcerntobothbuyersandsellers.Itisalsooneofthemostimportantlegalissuesinthesalescontractandplaysaveryimportantroleinthecontractlaw.Thispaperisaimingattheissuesoftheburdenofriskinbusinesscontractandtheimprovementofthesystemofriskofbusinesscontractlegislationsuggestions,inordertomakecontractriskburdenhasacertainroleinpromoting.

简介：Allorganisms,rangingfromsingle-celledorganismstohumans,demonstratecircadianrhythmsthatarenear24-hpatternsthatarepresentindependentofenvironmentalcues.Disruptionofthisprocess,calledcircadianmisalignment,isassociatedwithdeleterioushealthoutcomes.Themostextremeexampleofthismisalignmentisshiftwork,andthereisevidencesuggestingastrongassociationbetweenshiftworkandcertaincardiovascularoutcomes.Theoutcomesofmoststudiesincludeobesity,metabolicsyndrome,hypertension,type2diabetesmellitus,atrialfibrillation,andcardiovascularevents.Inthisarticlewereviewthecurrentliteraturewithanemphasisonwomen’scardiovascularhealth.Thedataareconflicting,andthereisapaucityofrobustevidencewithregardtowomen’scardiovascularhealthandcircadianmisalignment.Morestudiesareneededtobetterdelineatethesexdifferencesaswellasthepathophysiologyoftheassociationsbetweencircadianmisalignmentandcardiovasculardiseasessothatwecanprovidepatientswithmorepersonalizedcare.

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简介：一条高效轨道和抓住(T/H)电路设计因为高分辨率的高速度的analog-to-digital变换器(模数转换器)被介绍，它在0.18m互补金属氧化物半导体过程被实现了。一改善自举，切换体积的技术被介绍极大地在宽带宽，和增加上最小化采样网络的非线性一修改预先控告减少全部的电源消费的电路帮助。试验性的结果证明建议T/H电路以100MHz采样率完成超过77dBSFDR(假免费的动态范围)和70dBTHD(全部的泛音失真)并且当消费47mW电源时，与输入频率维持性能直到305MHz。

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