简介:AcutelyisolatedmousehippocampalCA3pyramidalneuronswereexposedto3mTstaticmagneticfield,andthecharacteristicsoftransientoutwardK+channelwerestudiedusingthewhole-cellpatch-clamptechnique.Theexperimentrevealedthattheamplitudeoftransientoutwardpotassiumchannelcurrentwasreduced.Themaximumactivatedcurrentdensitiesofcontrolgroupandexposuregroupwere163.62±20.68pA/pFand98.74±16.57pA/pF(n=12,P<0.01)respectively.Thestaticmagneticfieldexposureaffectedtheactivationandinactivationprocessoftransientoutwardpotassiumchannelcurrent.Duetothemagneticfieldexposure,thehalf-activationvoltageoftheactivationcurveschangedfrom5.59±1.96mVto27.87±7.24mV(n=12,P<0.05),andtheslopefactorchangedfrom19.43±2.11mVto25.87±4.22mV(n=12,P<0.05).Thehalf-inactivationvoltageoftheinactivationcurvesalsochangedfrom-56.09±0.89mVto-57.16±1.10mV(n=12,P>0.05)andtheslopefactoroftheinactivationcurvesfrom8.69±0.80mVto10.87±1.02mV(n=12,P<0.05).TheresultsshowthatthestaticmagneticfieldcanchangethecharacteristicsoftransientoutwardK+channel,andaffectthephysiologicalfunctionsofneurons.
简介:综述了研究CaCu3Ti4O12材料反常巨介电特性的理论和实用意义.给出了CaCu3Ti4O12结构示意图和X射线衍射(XRD)谱.评述了制备不同维度CaCu3Ti4O12材料的常规制备方法、优缺点及低温下介电性能测定方法.从内禀和外赋的角度,分析了影响CaCu3Ti4O12巨介电特性的各种可能因素.指出了目前该材料研究需要解决的一些问题.