简介：一系列1,4代用品phthalazine衍生物被设计并且综合。所有准备混合物在vitro对A549，HT-29和MDA-MB-231房间线为他们的细胞毒素的活动被屏蔽。在他们之中，混合物7a鈥?h从1nmol/L与IC50价值为MDA-MB-231房间线显示出优秀选择到0.92渭mol/L。这些衍生物的初步的SAR研究被执行。

简介：Resinsofcomplexesmadefromagarose-Ce4+(RCA-Ce)andchitosan-Ce4+(RCC-Ce)wereprepared.Hydrolysisratesofmethamidophos,omethoateandchlorpyrifostreatedbyRCA-Cewere32.39%,27.12%and46.62%,respectively,thoseofchlorpyrifosandmethamidophosinmungbeansproutjuice38.28%and35.45%,andthatofchlorpyrifosinteaextract59.76%.HydrolysisratesofproteininteaextracttreatedbyRCA-Ceincreasedby86.46%.RCC-Cecouldbeemployedintheapplejuiceproduction.Thecontentsofmethamidophosandparathion-methylinthejuicetreatedbyRCC-Cedecreased58.76%and71.92%.Furthermore,RCC-Cewasusedtoclarificationforbeerbythewaysofacolumn.RCC-Cecouldhydrolyzesensitiveproteinandincreasecontentsoffreeaminoacidinthebeer.Therefore,thebeertreatedbyRCC-CecouldstayoxidationandagingprocedureduetosomemetalionsbeingabsorbedbyRCC-Ce.

简介：四新triterpenesaponins，和五已知的混合物(5-9)，mandshunosidesF-I(1-4)从铁线莲mandshurica的根和根茎被孤立。他们的结构根据分光镜的证据和水解作用产品被阐明。Bisdesmosidicsaponin(3-9)在51.3%-的范围与抑制比率显示出没有生产的谦虚抑制64.6%在50摩尔

简介：Twoseriesofnewcompounds:thealiphaticacylaminoethylglycines(Ⅰ)andtheircyclo-condensationproducts-allphaticacylaminoethylplperazlnones(Ⅱ)weresynthesized.Theresultsofbactericidalandbacteriostatictestsshowthatthetwoseriesofcompoundsaregoodbactericldalagents.

简介：ThedemofacilityofchinaADSinjectorIIwasinstalledinthetunnelin2014.Theon-sitelayoutofdemofacilityisshownintheFig.1.ThedemofaclitymainlyincludesECRIS,LEBT,RFQacclerator,MEBTandTCM6.TheTCM6iscomposedbysixSCHWRcavity,sixSCsoleniodsandfiveBPMs.TheTCM6willbetheprototypeforthefuture2025MeVCADSsuperconductinglinac.ThebeamcommissioningofCADSInjectorIIstartedinJune2015.Itmainlyconsistsofthreesteps.

简介：Basedonthefloodaffectedarea(FA)dataoftheprovincesinChinafrom1950to2005,thearticlediscussesthechangeofthefloodpatternsinChina,andinvestigatesitsrelationshipwithclimatechangeandhumanactivities.ThefloodcentershiftedfromNorthChinaandtheYangtze-Huaihebasininthe1950stowardsthesouth,northandwestofChina,andlocatedinthesouthoftheYangtzeRiverandSouthChinaafterthe1990s.TheFAinthewesternprovinceswascontinuouslyontherisesincethe1950s.TherearetwocharacteristicsforthefuturefloodpatterninChina.Thepatternof'floodinthesouthanddroughtinthenorth'dependsonthenorth-southshiftofthemaximumrainfallregionineasternChina.ThefloodintensificationtothewestofHuHuanyong'slinemainlyresultsfromtheincreaseofrainfall,extremeprecipitationandthemeltingofglaciersunderthebackgroundofhumanactivitymagnification.

简介：CymbopogoncitratusisawidelydistributedperennialherbbelongingtothePoaceaefamilyandhasbeenextensivelyconsumedforitsmedicinal,cosmetic,andnutritionaleffectsforcenturies.Alargenumberofreportshavebeenpublisheddescribingthepharmacological,biological,andtherapeuticactionsofthisherb.Inthisreview,wesummarizedtheliteraturesonrelatedstudies(uptoJanuary,2014)thathighlightedthepharmacologicandbiologicaleffectsofthemajorphytochemicalsisolatedfromC.citratusextractsanditsessentialoil.ThecomponentsoftheessentialoilsfoundinC.citratushaveasimilarpharmacokineticproperties,includingabsorption,distribution,metabolism,andexcretion.Theyarequicklyabsorbedfollowingoral,pulmonary,anddermaladministration.Basedonthepublishedreports,itcanalsobeinferredthat,afterabsorptionfromthesmallintestine,somephytochemicalsinC.citratuscanundergooxidation,glucuronidation,sulfation,and/orO-methylation.Excretionisthroughurine,fecesand/orexpiredvolatiles.ThebiotransformationreactionsofC.citratusbioactiveconstituentsareessentialforitsrelativelysafeconsumptionandtherapeuticapplications.ThedataavailablesofarwarrantfurtherstudiesevaluatingC.citratuspharmacokinetics.ReliablepharmacokineticdatainhumanswouldbecriticalforabetterunderstandingofthethesystemichandlingofC.citratus.

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简介：Ｔｈｅｓｙｎｔｈｅｓｉｓｏｆｐｏｒｐｈｙｒｉｎｎｉｔｒｏｇｅｎｍｕｓｔａｒｄｓｆｒｏｍｄｅｕｔｅｒｏｐｏｒｐｈｙｒｉｎａｎｄ３，８ｄｉａｌｋｙｌｏｘｙｈｅｍａｔｏｐｏｒｐｈｙｒｉｎｍｅｔｈｙｌｅｓｔｅｒｓｔｈｒｏｕｇｈｒｅｄｕｃｔｉｏｎ，ｂｒｏ...

简介：在小世界网络基于我们的以前联合脉搏的integrate-and-Gre神经原模型，我们在这个模型生产的象electroencephalographic一样信号的复杂行为上调查不同连接拓扑学的效果。我们证明若干次，经常是的系列分析方法使用了分析electroencephalographic-likesignals的复杂行为，例如在重新可伸缩的范围分析(R/S)以内的阶段空间，关联尺寸，分数维的尺寸，和林中小丘代表的重建。我们发现不同连接拓扑学在integrate-and-fire神经原的模型导致不同动态行为。

简介：ByapplyingtwononlinearGrangercausalitytestingmethodsandrollingwindowstrat-egytoexploretherelationshipbetweenspeculativeactivitiesandcrudeoilprices,theunidirectionalGrangercausalityfromspeculativeactivitiestoreturnsofcrudeoilpricesduringthehighpricephaseisdiscovered.ItisprovedthatspeculativeactivitiesdidcontributetohighcrudeoilpricesaftertheAsianfinancialcrisisandOPEC'soutputcutin1998.TheunidirectionalGrangercausalityfromreturnsofcrudeoilpricestospeculativeactivitiesissignificantingeneral.Butafter2000,withthesharpriseincrudeoilprices,thisunidirectionalGrangercausalitybecameacomplexnonlinearrelationship,whichcannotbedetectedbyanylinearGrangercausalitytest.

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简介：TheeffectsonhepaticEROD(7-ethoxyresorufinO-deethylase)inMugilso-iuyexposedtobenzo(a)pyrene(BaP),pyreneandtheirmixturesofequalconcentrationwereinvestigated,atconcentrationsof0.1,1.0,5.0,10.0,50.0μg/dm3,inexperimentalcondition.Time-effectsanddoseresponseofthebiochemicalindexswereobserved.TheresultsshowedthatthehepaticERODactivitieswereinducedbytheexposureofBaP,pyreneandtheirmixturesathighconcentration.Dose-responseconnectionswerethatthehepaticERODactivitieswereelevatedwithincreasingconcentrationofthepollutants.ThecombinedeffectofBaPandpyreneat1:1concentrationratioonhepaticERODactivitywasantagonism.

简介：3α-bromo-epipicropodophyllinwaspreparedanditsinhibitionactivitiesagainstKBcellsandL1210leukemiacellsinvitroarehigherthanthoseofVP-16,awidelyuseddruginclinicatpresent.ThisisthefirsttimetointroducesubstitutionatC-3ofring-Cintheworkofmodifyingstructureofpodophyllotoxin.Itcanbetransformedeasilyto4β-hydroxy-2,3-ene-apopicropodophyllinunderbasiccondition,sothat,correspondingderivativesof2,3-ene-apopicropodophyllinwithsubstitutiononcarbon-4couldbesynthesized.Thiscompoundcanberegardednotonlyasaleadingcompoundtobemodifiedbecauseofitsantitumoractivities,butalsoasanintermediateforthestructuretransformation.

简介：Juglansmandshurica格言的绿皮的摘录是为学习它的杀虫的活动并且分析活跃部件的提取bycommon方法。白酒摘录和氯仿摘录分开的Resultsshowed(用氯仿fromalcohol摘录分开了)J的形式绿色皮。mandshurica对LymantriadisparL的幼虫在接触toxicityand胃毒性举办杀虫的活动...在摘录forfive天的申请以后，为两篇摘录的Lymantriadispar的幼虫的改正的死亡是在≥的集中的超过50%in接触毒性和胃毒性5g·L~(-1)。为白酒摘录和摘录的氯仿部分的insecticidalactivity是在在胃毒性的接触toxicitythan的更多的效果，但是在杀虫的活动的重要差别都不是摘录的foundbetween白酒摘录和氯仿部分。在从绿皮of/mandshurica的氯仿partof摘录的活跃部件被GCMS分析。分析结果证明在氯仿的活跃部件摘录分开的thatthe是：(1)juglone(5-hydroxy-l,4-naphthaoquinone)，相对内容27.11%，(2)1,5-Naphthalenediol，相对内容9.52%，(3)7-Methoxy-l-tetralone，相对内容6.81%，(4)Benzofuran，2,3-dihydro-，relativecontent6.76%，(5)4-Hydroxy-2-methoxycinnamaldehyde，相对内容3.99%，(6)2-Methoxy-4-vinylphenol，相对内容3.05%。

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简介：Stablesilvernanoparticleswassuccessfullysynthesizedbychemicalreductionofsilvernitrateinanionicliquid,1-n-butyl-3-methylimidazoliumtetrafluoroborate([BMIM]·BF4)atroomtemperature.ResultsofUV-Visdiffusereflectancespectroscopyshowas-preparedAgnanoparticlesexhibitatypicalemissionpeakat400―430nm.Byvaryingthereactiontemperatureandtheprecursorconcentration,thesizeandtheshapeofthesilvernanoparticlescouldbeeasilycontrolledundermildconditions.Analysesoftransmissionelectronmicrographs,X-raydiffractionpatternandX-rayphotoelectronspectrumfurtherrevealthatthesilvernanoparticleswerecoatedincompletelyby[BMIM]·BF4.Microbialexperimentsindicatethatas-preparedsilvernanoparticlesshowawidespectrumofantimicrobialactivitiesandhavebetterantimicrobialactivitiestoPseudomonasaeruginosathansilvernitratewiththesameconcentrationofsilver.