简介：Themulticoreevolutionhasstimulatedrenewedinterestsinscalingupapplicationsonshared-memorymultiprocessors,significantlyimprovingthescalabilityofmanyapplications.Butthescalabilityislimitedwithinasinglenode;thereforeprogrammersstillhavetoredesignapplicationstoscaleoutovermultiplenodes.Thispaperrevisitsthedesignandimplementationofdistributedsharedmemory(DSM)asawaytoscaleoutapplicationsoptimizedfornon-uniformmemoryaccess(NUMA)architectureoverawell-connectedcluster.ThispaperpresentsMAGI,anefficientDSMsystemthatprovidesatransparentsharedaddressspacewithscalableperformanceonaclusterwithfastnetworkinterfaces.MAGIisuniqueinthatitpresentsaNUMAabstractiontofullyharnessthemulticoreresourcesineachnodethroughhierarchicalsynchronizationandmemorymanagement.MAGIalsoexploitsthememoryaccesspatternsofbig-dataapplicationsandleveragesasetofoptimizationsforremotedirectmemoryaccess(RDMA)toreducethenumberofpagefaultsandthecostofthecoherenceprotocol.MAGIhasbeenimplementedasauser-spacelibrarywithpthread-compatibleinterfacesandcanrunexistingmultithreadedapplicationswithminimizedmodifications.WedeployedMAGIoveran8-nodeRDMA-enabledcluster.ExperimentalevaluationshowsthatMAGIachievesupto9.25:4speedupcomparedwithanunoptimizedimplementation,leadingtoasealableperformanceforlarge-scaledata-intensiveapplications.

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简介：我们从四波浪的混合在二模式的轻地的量关联上探索原子记忆的效果。在配置的一个三水平的原子系统被考虑，在哪个原子松驰时间比洞松驰乘并且这样在那里存在的比得上或长原子存储器。没有原子变量的断热的消除，在产量的量关联光谱被计算。连续可变纠纷被提高在上，这被显示出大量在中间、坏的洞盒子中的规范的detuning与好洞盒子相比。处于一些状况，更多的重要改进发生在边带。

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简介：TheproblemofflappingmotioncontrolofMicroAirVehicles(MAVs)withflappingwingswasstudiedinthispaper.Basedupontheknowledgeofskeletalandmuscularcomponentsofhummingbird,adynamicmodelforflappingwingwasdeveloped.AcontrolschemeinspiredbyhumanmemoryandlearningconceptwasconstructedforwingmotioncontrolofMAVs.Thesalientfeatureoftheproposedcontrolliesinitscapabilitiestoimprovethecontrolperformancebylearningfromexperienceandobservationonitscurrentandpastbehaviors,withouttheneedforsystemdynamicinformation.Furthermore,theoverallcontrolschemehasafairlysimplestructureanddemandslittleonlinecomputations,makingitattractiveforreal-timeimplementationonMAVs.Boththeoreticalanalysisandcomputersimulationconfirmsitseffectiveness.

简介：AbstractToinvestigatetheroleofCD4^+helperT(Th)cellsinthememoryCTL-mediatedanti-tumorimmunity,theRAG-1geneknockoutmicewereadoptivelytransferredwithOT-1cellstogeneratethememoryCTL,theC57B1/6miceimmunizedwiththeepitopepeptideofOVAspecificThcellsandwithdifferentadjuvantswereadopfivelytransferredwiththesememory-CTLs,andthentheanimalswerechallengedwithtumorcellsEGT.ItwasfoundthatalthoughthesimpleimmunizationofmicewiththeepitopepeptideoftheOVAspecificThcellscouldgeneratemoreeffectCTL,butthiseffectwasnotsostrongenoughtoresistcompletelythechallengeswithtumorcells.Nevertheless,thememoryCTL-mediatedanti-tumorimmuneeffectrequiredthehelpsofTh1andTh2cells.Thecross-regulationbetweenThlandTh2cellsseemedtobebeneficialforthehosttogeneratemoreeffectorCTLformountinganefficientanti-tumorresponse.ItconcludedthattheinteractionbetweenThlandTh2cellsmightbemoreimportantthanthesinglesubsetofThcellsinthememoryCTL-mediatedanti-tumorimmuneresponse.Moreattentionshouldbepaidinthisregardforthefuturestudies.

简介：Newnon-volatilememory(NVM)technologiesareexpectedtoreplacemainmemoryDRAM(dynamicrandomaccessmemory)inthenearfuture.NANDflashtechnologicalbreakthroughshaveenabledwideadoptionofsolidstatedrives(SSDs)instoragesystems.However,flash-basedSSDs,bynature,cannotavoidlowenduranceproblemsbecauseeachcellonlyallowsalimitednumberoferasures.ThiscangiverisetocriticalSSDreliabilityissues.SincemanySSDwriteoperationseventuallycausemanySSDeraseoperations,reducingSSDwritetrafficplaysacrucialroleinSSDreliability.ThispaperproposestwoNVM-basedbuffercachepolicieswhichcanworktogetherindifferentlayerstomaximallyreduceSSDwritetraffic:amainmemorybuffercachedesignnamedHierarchicalAdaptiveReplacementCache(H-ARC)andaninternalSSDwritebufferdesignnamedWriteTrafficReductionBuffer(WRB).H-ARCconsidersfourfactors(dirty,clean,recency,andfrequency)toreducewritetrafficandimprovecachehitratiosinthehost.WRBreducesblockerasuresandwritetrafficfurtherinsideanSSDbyeffectivelyexploitingtemporalandspatiallocalities.ThesetwocomprehensiveschemessignificantlyreducetotalSSDwritetrafficateachdifferentlayer(i.e.,hostandSSD)byupto3x.Consequently,theyhelpextendSSDlifespanwithoutsystemperformancedegradation.

简介：Microstructuresandpropertiesofcapacitordischargewelded(CDW)jointofTiNishapememoryalloy(SMA)andstainlesssteel(SS)werestudied.Thefracturecharacteristicsofthejointwereanalyzedbymeansofscanningelectronmicroscope(SEM).MicrostructuresofthejointwereexaminedbymeansofopticalmicroscopeandSEM.Theresultsshowedthatthetensilestrengthoftheinhomogeneousjoint(TiNi-SSjoint)waslowandthejointwasbrittle.BecauseTiNiSMAandSSmelted,abrittleas-caststructureandcompoundwereformedintheweld.Thetensilestrengthandtheshapememoryeffect(SME)ofTiNi-SSjointwerestronglyinfluencedbythechangesofcompositionandstructureoftheweld.MeasuresshouldbetakentopreventdefectsfromformingandextrudingexcessivemoltenmetalintheweldforimprovingthepropertiesofTiNi-SSjoint.

简介：AbstractLeucine-rich repeats containing 4 (LRRC4, also named netrin-G ligand 2 [NGL-2]) is a member of the NetrinGs ligands (NGLs) family. As a gene with relatively high and specific expression in brain, it is a member of the leucine-rich repeat superfamily and has been proven to be a suppressor gene for gliomas, thus being involved in gliomagenesis. LRRC4 is the core of microRNA-dependent multi-phase regulatory loops that inhibit the proliferation and invasion of glioblastoma (GB) cells, including LRRC4/NGL2-activator protein 2 (AP2)-microRNA (miR) 182-LRRC4 and LRRC4-miR185-DNA methyltransferase 1 (DNMT1)-LRRC4/specific protein 1 (SP1)-DNMT1-LRRC4. In this review, we demonstrated LRRC4 as a new member of the partitioning-defective protein (PAR) polarity complex that promotes axon differentiation, mediates the formation and plasticity of synapses, and assists information input to the hippocampus and storage of memory. As an important synapse regulator, aberrant expression of LRRC4 has been detected in autism, spinal injury and GBs. LRRC4 is a candidate susceptibility gene for autism and a neuro-protective factor in spinal nerve damage. In GBs, LRRC4 is a novel inhibitor of autophagy, and an inhibitor of protein-protein interactions involving in temozolomide resistance, tumor immune microenvironment, and formation of circular RNA.

简介：AIM:ToexploretheeffectsofCompoundYi-Zhi(YZC)onlearningandmemorycapacityandfreeradicalmetabolisminD-galactoseinducedmicedementiamodel.METHODS:ThemicedementiamodelwasinducedbyadailyD-galactose0.15g/kgscfor45daysandafter5days'D-galactoseinjection,themiceweretreatedwiththreedosesofYZC

简介：Objective:ToexplorethemechanismofEcdysterone(ECR)inpreventionoflearningandmemorydysfunctionoftheratsinducedbyβ-amyloidpeptide(Aβ25-35).Methods:NinetyWistarmaleratswererandomlydividedintofivegroups,thecontrolgroup,themodelgroup,thetreatedgroups(ECR4mg·kg^-1andECR8mg·kg-1andNimodipine

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简介：在决定与形状记忆合金(SMA)使用结构的隔离的有效性考虑的关键点是组成的模型，SMA隔离设备和分析方法。在这份报纸，一个简化组成的模型基于粘性的经典理论被建议模仿SMA，马氏体体积部分在被看作州的变量之一的superelasticity的行为。在模拟结果和试验性的结果之间的比较被做并且显示建议组成的模型产出在对试验性的好同意的压力紧张曲线。因此，建议模型能正确地模仿收益机制和SMA的精力驱散能力。下次，以便充分利用SMA的superelasticity，由pre-tensionedSMA酒吧组成的新SMA隔离乾被介绍。然后，一个有限元素分析模型被建立根据它的配置模仿SMA隔离乾的行为并且简化了组成的模型。最后，为与SMA隔离乾安装的长跨度的结构的一个简化设计方法被建议，它进一步被用来调查空间格子结构的隔离效果。结果证明SMA隔离乾能有效地减少结构的地震回答，它显示建议SMA隔离方法的有效性。

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简介：SharedMemory(SM)switchesarewidelyusedforitshighthroughput,lowdelayandefficientuseofmemory.ThispapercomparestheperformanceoftwoprominentswitchingschemesofSMpacketswitches:Cell-BasedSwitching(CBS)andPacket-BasedSwitching(PBS).Theoreticalanalysisiscarriedouttodrawqualitativeconclusiononthememoryrequirement,throughputandpacketdelayofthetwoschemes.Furthermore,simulationsarecarriedouttogetquantitativeresultsoftheperformancecomparisonundervarioussystemload,trafficpatterns,andmemorysizes.SimulationresultsshowthatPBShastheadvantageofshortertimedelaywhileCBShaslowermemoryrequirementandoutperformsinthroughputwhenthememorysizeislimited.Thecomparisoncanbeusedfortradeoffbetweenperformanceandcomplexityinswitchdesign.

简介：Wearabledevicesbecomepopularbecausetheycanhelppeopleobservehealthcondition.Thebatterylifeisthecriticalproblemforwearabledevices.Thenon-volatilememory(NVM)attractsattentioninrecentyearsbecauseofitsfastreadingandwritingspeed,highdensity,persistence,andespeciallylowidlepower.Withitslowidlepowerconsumption,NVMcanbeappliedinwearabledevicestoprolongthebatterylifetimesuchassmartbracelet.However,NVMhashigherwritepowerconsumptionthandynamicrandomaccessmemory(DRAM).Inthispaper,weassumetousehybridrandomaccessmemory(RAM)andNVMarchitectureforthesmartbraceletsystem.Thispaperpresentsadatamanagementalgorithmnamedbraceletpower-awaredatamanagement(BPADM)basedonthearchitecture.TheBPADMcanestimatethepowerconsumptionaccordingtothememoryaccess,suchassamplingrateofdata,andthendeterminethedatashouldbestoredinNVMorDRAMinordertosatisfylowpower.TheexperimentalresultsshowBPADMcanreducepowerconsumptioneffectivelyforbraceletinnormalandsleepingmodes.

简介：记忆B和T淋巴细胞的功能的角色位于预防种痘的非凡的成功下面，它减少了从传染疾病的病态和死亡全球性在最后50年。然而，逐渐地欣赏了那，正在变得记忆房间也能够调停与自体免疫的混乱联系的病理并且移植拒绝，并且可以提出一个重要障碍到未来在immunoregulation的临床的前进。因此，理解记忆淋巴细胞的唯一的性质(作为与他们的天真的先锋相比)是调查的一个主要区域。这里，我们集中于记忆T房间(TM)的那些单个性质之一鈥攔apid召回。当愿望更详细地被讨论，快速的召回指静止TM房间的能力到“高效地并且要用体力地快速的受动器功能”跟随刺激。用CD4+T房间推进了我们TM房间的快速的召回的理解的研究是熟练地在其它地方考察了1，我们将因此首先集中于CD8+T房间的研究。我们将首先考察CD8+TM房间能被产生的不同方法，由讨论这怎么在有免疫力的保护和病理的背景影响他们的功能的性质列在后面。然后，快速的召回能力将被讨论，与放在当前对机制被知道位于TM房间的这个唯一的性质下面的上的强调。

简介：Noisepollutionisamajorhazardousfactortohumanhealthandislikelyharmfulforvulnerablegroupssuchaspre-terminfantsunderlifesupportsysteminanintensivecareunit.Previousstudieshavesuggestedthatnoiseexposureimpairschildren’slearningabilityandcognitiveperformanceandcognitivefunctionsinanimalmodelsinwhichtheeffectismainlyattributedtotheoxidantstressofnoiseonthecognitivebrain.Thepotentialroleofnoiseinducedhearingloss(NIHL),ratherthantheoxidantstress,hasalsobeenindicatedbyadepressionofneurogenesisinthehippocampuslongafterabriefnoiseexposure,whichproducesonlyatentativeoxidantstress.ItisnotclearifnoiseexposureandNIHLduringearlydevelopmentexertsalongtermimpactoncognitivefunctionandneurogenesistowardsadulthood.Inthepresentstudy,abriefnoiseexposureathighsoundlevelwasperformedinneonatalC57BL/6Jmice(15daysafterbirth)toproduceasignificantamountofpermanenthearinglossasproved2monthsafterthenoise.Atthisage,thenoise-exposedanimalsshoweddeterioratedspatiallearningandmemoryabilitiesandareductionofhippocampalneurogenesisascomparedwiththecontrol.Theaveragedhearingthresholdwasfoundtobestronglycorrelatedwiththescoresforspatiallearningandmemory.Weconsidertheeffectsobservedarelargelyduetothelossofhearingsensitivity,ratherthantheoxidantstress,duetothelongintervalbetweennoiseexposureandtheobservations.

简介：在这篇论文，我们在不同计算设定在n宽度上从空格l_p(1≤p≤2)为斜操作符T把一些最佳的算法给l_2。

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