简介:neovascularization的形成是许多眼睛的脉管的疾病的一个普通病理学的特征,并且是在病人的视觉损失的一个重要原因。Neovascularization能引起网膜的出血,玻璃的出血,和另外的严肃的复杂并发症,导致视觉的损失。intraocularneovascularization的治疗是眼科学研究的焦点。在最近的年里,一些研究发现了autophagy是仔细与脉管的endothelial生长因素和neovascularization的形成有关。Autophagy被期望为intraocularneovascularization的治疗成为一个新目标。因此,这篇文章在autophagy和intraocularneovascularization的形成上考察研究。
简介:FromJune,1986toJune1989,24casesofhilarbileductcarcinomawereexploredintheSurgicalDepartmentofGeneralHospitalofPLA,16/24caseswereresected,aresectabilityrateof66%.Theincreaseofresectabilityratewasduetoearlierrecognitionofthisconditionandtheextensionofsurgery,includingmajorresectionofliveraswellasradicaldissectionofthehepato-duodenalligamentandrepairativeoperationsonthebloodvessels.Amongthese16cases,majorhepaticresectionwasperformedin10cases,inwhich,3casesofresectionsofthemiddlelobeoftheliverweredoneinsteadofrightorextendedrightlobectomy.Nooperativemortalityinthe30days’postoperativeperiod,butthepostoperativemorbidityratewasstillhighandmostofthecomplicationswererelatedtobiliaryleakageandinfection.Threepatientsdiedinthefollowupperiodat6,14and15monthsrespectively.Allofthemdiedfrombiliaryinfection.Theremaining13patientswerestillalive,thelongestbein
简介:Objective:Toevaluatethetherapeuticeffectofacupunctureinthetreatmentofdepressivepsychosis.Methods:Atotalof62casesofdepressivepsychosispatientswererandomlydividedintotreatmentgroup(n=32)andcontrolgroup(n=30).AcupointsusedintreatmentgroupwerebilateralHegu(LI4),bilateralTaichong(LR3),Baihui(GV20)andYintang(EX-HN3).PatientsofcontrolgroupwereaskedtotakeFluoxertinehydrochloride20mg/d.ThetherapeuticeffectwasassessedusingHamilton'sdepression(HAMD)scales.Results:After8weeks'treatment,intreatmentandcontrolgroups,4and3caseswerecured,8and6experiencedmarkedimprovement,14and14hadimprovement,6and7hadnoeffect,withtheeffectiveratesbeing81.25%and76.66%separately,andnosignificantdifferencewasfoundbetweentwogroupsinHAMDscales(P>0.05).Conclusion:Acupuncturetherapyisaneffectivemethodfortreatmentofdepressivepsychosis.
简介:Objective:Toobservethetherapeuticeffectofclinicaltreatmentofacuteurticariachieflybyelectroacupuncture(EA).Methods:Atotalof180outpatientswithacuteurticariawererandomizedintotreatmentgroupandcontrolgroup.100casesinthetreatmentgroupwereweremanagedbychlorpheniraminemaleateandVitaminC.Results:After3days'treatment,ofthe100and80casesintreatmentandcontrolgroups,79and53werecured,10and6markedlyeffective,5and8effective,and6and13failed,withtheeffectiveratesbeing94.00%and83.75%respectively.Thetherapeuticeffectofelectroacupunturewassignificantlysuperiortothatofmedication(P<0.05).Conclusion:Thewasamoreeffectivetherapyforacuteurticaria.
简介:PracticehasprovedthatHospitalCultureandEnvironmentinfluenceseconomiceffectsdi-rectly.Soadaptingthenewlydirectedpatientmarketandcreatingagoodhospitalcultureandenvironmentwilltakeanactiveeffectonstrengtheningthecompetitiveadvantage.Besides,appropriateformsofartisticmovementworkindifferentaspectsofpatients.Theyrecuperatepatientsphysiologically,mentally,sociallyandpsychologically,anddispeltheirmisgivingsandhelpthemregainhealth.
简介:Fatiguecuttingisanewapproachforseparatingmaterial.Man-madefatiguecanberealizedbyapplyingarotatingbendingloadtoanotchedbar.Tobetterutilizethenewmethod,lasertreatmentisadoptedinthisstudy.Afterlaserradiationatthenotchroot,thefatiguecycleofthebardropsdramatically.Basedontheexperimentalresult,wedrawtheconclusionthatthefatigueofthebarisinfluencedbytheshapeofthehardenedarea.Ahardenedareathathasasmallaxialdimensionandarelativelylargeradialdimensionfacilitatesthefatigue.Thedesirablehardenedareacanbeobtainedbycontrollingthelasertreatmentparameters.
简介:Intractabletinnituscanleadtoseriousconsequences.Studyevidenceindicatesthatthecentralnervoussystemisinvolvedingenerationandmaintenanceofchronictinnitusandthattinnitusandotherneurologicsymptomssuchaschronicpainmaysharesimilarmechanisms.Brainablationandstimulationareusedtotreatchronicpainwithsuccess.Recentstudiesshowedthatablationandstimulationinnon-auditoryareasresultedintinnitusimprovement.Deepbrainstimulation(DBS)maybeanalternativetreatmentforintractabletinnitusanddeservesfurtherstudy.
简介:Sonodynamictherapy(SDT)isanemergingapproachthatinvolvesacombinationoflow-intensityultrasoundandspecializedchemicalagentsknownassonosensitizers.Ultrasoundcanpenetratedeeplyintotissuesandcanbefocusedintoasmallregionofatumortoactivateasonosensitizerwhichoffersthepossibilityofnon-invasivelyeradicatingsolidtumorsinasite-directedmanner.Inthisarticle,wecriticallyreviewedthecurrentlyacceptedmechanismsofsonodynamicactionandsummarizedtheclassificationofsonosensitizers.Atthesametime,thebreathofevidencefromSDT-basedstudiessuggeststhatSDTispromisingforcancertreatment.
简介:AbstractThalassemia, classified as the main types α- and β-thalassemia, is a single gene disorder resulting from globin chain synthesis impairment through the mutation or deletion of globin genes. The incidence of thalassemia is high worldwide, with high associated mortality. Therefore, treatment is important to improve patient outcomes. This paper reviews the current status of β-thalassemia major in China, including its epidemiology and treatment.
简介:Objectives:Toevaluateoutcomesintreatingcarcinomaofexternalauditorycanal(EAC)andtoanalysisfactorswhicheffecttheprognosisofthisdisease.Methods:Aretrospectivelyreviewof16patientstreatedforcarcinomaofEACatourdepartmentbetweenApril2000andApril2014wasconducted.Allpatientsunderwentsurgicaltreatmentandthediagnosisconfirmedbypathologicalexamination.Results:Therewereadenoidcysticcarcinoma(ACC)in8patients,squamouscellcarcinoma(SCC)in5patients,adenocarcinoma(AC)in2patients,andverrucouscarcinoma(VC)in1patient.ThetumorswereclassifiedasStageIin4cases,StageIIin2cases,StageIIIin3cases,andStageⅣin7cases.Fivepatientsunderwentextensivetumorresection(ETR),2patientsunderwentlateraltemporalboneresection(LTBR),5patientsunderwentmodifiedLTBR,2patientsunderwentsubtotaltemporalboneresection(STBR),and2patientsunderwentonlyopenbiopsy.Besides,adjunctiveprocedures,includingneckdissection,parotidectomyandpinnaresectionwereperformedwhenindicated.Tenpatientsreceivedpostoperativeradiotherapy.Bytheendoffollowup,twopatientshaddiedoftheirdisease,2losttofollowup,2survivedwiththedisease,andtherestsurviveddisease-free.Themedianfollow-upperiodwas24months.Conclusion:CompletetumorresectionappearstobeaneffectivetreatmentforcarcinomaoftheEAC.PatientswithSCCseemtohaveworseprognosisthanthosewithACC.Radiationtherapyseemslesseffectiveforihediseasethansurgicaltreatment.
简介:Ashipoint(tonsil)incombinationoftheprickingandbleedingtechniqueonShaoshang(LU11)andShangyang(LI1)wereusedtotreat58outpatientsofacutetonsillitis.Theresultsshowedcurein38cases,remarkableeffectin17casesandfailurein3casesbyonetreatment,andthetotaleffectiveratein95%.
简介:ObjectiveToretrospectivelystudyclinicalfeaturesanddiagnosticimagingofvasculogeneicpulsatiletin-nitus,andthefeasibilityandefficacyoftransvascularinterventionaltreatmentforthiscondition.MethodsDatafrom82casesofarterialorvenouspulsatiletinnituswerereviewed.DSAcharacteristicsandpossiblepathophysiologicalmechanismsofpulsatiletinnitusinthesecaseswerestudied.Diagnosesinthisgroupin-cludedintracranialarterovenousfistula(AVF)(n=3),spontaneousskullbaseduralAVF(n=16),traumaticca-rotid-cavernoussinusfistula(n=5),subclavianarterystenosis(n=2),internalcarotidarterystenosis(n=3),in-tracranialarterialstenosis(n=1),kinkedand/orelongatedvertebrobasilarartery(n=2),venoussinusdivertic-ulum(n=2),venoussinusstenosisonthedominantdrainageside(n=46)andoccipitalsinusstenosis(n=2).Treatmentsincludedembolizationandstentingusingcoils,NBCAglue,Baltballoons,self-expansionstentsandintracranialmicro-stentsviaeitherthefemoralarteryorfemoralvein.ResultsProceduresweresuc-cessfulinallcaseswithnosurgery-relatedcomplications.Tinnitusdisappearedwithin2daysafterthepro-cedureinallcases.Followupdurationwas5-36months.Recurrenceoccurredin4casesofarterialtinnituswithin3monthsfollowingtheinitialprocedure,whichimprovedafterrevisionembolizationorsymptommanagement.Therewasnorecurrenceinvenoustinnituscasesfollowingstentplasticorstent-coilingembo-lizationtreatments.ConclusionsEndovascularinterventionprovidesanewapproachtothediagnosisandtreatmentofintractablepulsatiletinnitus.Itisalsoeffectiveindifferentiatingandstudyingothertypesoftinnitus.