简介:ObjectiveToanalyzethecharacteristicsofauditorybrainstemresponse(ABR)inpresbycusispatientsel-derthan90years.MethodsFourteenpresbycusispatientselderthan90years(presbycusisgroup,91.1.4±1.3years,26ears)and9normal-hearingyoungadults(controlgroup,22.7±1.2years,18ears)participatedinthestudy.Alternativeclick-evokedABRswererecordedinbothgroups.Thepeaklatency(PL)ofpeakI,Ⅲ,andV,andtheinter-peaklatency(IPI)ofI-Ⅲ,Ⅲ-V,andI-Vwerecomparedbetweengroups.ResultsInelderpresbycusispatients,theoccurrencerateofpeakIandⅢwereboth76.9%,andthatofpeakVwas84.6%.Inpresbycusisgroup,thepeaklatenciesofI,Ⅲ,Vweresignificantlylongerthanthatofcontrolgroup(P<0.001).TherewasnosignificantdifferencebetweengroupsintheIPIofpeakI-IⅢ(P=0.298,peakⅢ-V(P=0.254)andpeakI-V(P=0.364).ConclusionsAuditorybrainstemresponsesinpresbycusispa-tientselderthan90yearsshowedworsewavedifferentiation.
简介:目的:分析90岁以上老年性聋患者听性脑干反应(ABR)的特征。方法对14例90岁以上老年性聋患者(平均年龄91.1.4±1.3岁,26耳)进行交替短声ABR测试。听力正常人9例(平均年龄22.7±1.2岁,18耳)作为对照组。观测Ⅰ、Ⅲ、Ⅴ波的峰潜伏期(PeakLatency,PL)和Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期(Inter-PeakLatency,IPL),并分别与对照组总体均数进行比较。结果总体的I波引出率和Ⅲ波引出率均为76.9%(20/26),V波引出率为84.6%(22/26)。高龄老年性聋组各波PL较对照组延长。Ⅰ-Ⅲ波IPL、Ⅲ-Ⅴ波IPL、Ⅰ-Ⅴ波IPL无组间统计学差异。结论90岁以上高龄老年性聋患者ABR波形分化较差。
简介:恶性肿瘤是一类细胞周期疾病,几乎所有癌基因、抑癌基因的生物学效应,最终都会集到细胞周期机制上来。细胞周期蛋白D1(CyclinD1)作用于细胞周期的G1→S期调控点,为G1期的限速步骤。研究CyclinD1与头颈部恶性肿瘤发生发展的关系,对了解头颈部恶性肿瘤的发病机制以及基因疗法的开展提供依据。本文对CyclinD1在头颈部恶性肿瘤发生发展中的作用做一综述。
简介:Aim:Toassessthequalityofhigh-resolutionCTsectionplanes(HRCT),multi-planarreformation(MPR)and3-dimensionalvolumerenderedcomputertomography(3D-CTVR)werehereusedinthefinedifferentialdiagnosisofossicularchaininthecaseofconductivehearinglosswithintacttympanicmembrane.Methods:Here,17casesofotosclerosisand22casesofossicularchaindeformitywereselected.Allpatientshadnormalexternalearcanals,intacttympanicmembranes,conductivehearingloss,typeAtympanograms,andnegativeGelle'stests.Therespectiveradiologicalreportsofthestatusoftheossiclesvia3protocolswerecomparedtosurgicalfindings.Thequantitativeassessmentsoftherepresentationofdifferentsegmentsoftheossicularchainwerebasedona3-pointscoringsystem.Results:MPRandCTVRimagingbothshowedtheintegrityofwholeossicularchainwell.MPRandCTVRimagingwerefoundtobesuperiortosectionplaneswithrespecttoshowingthesuperstructureofthestapesandmalformations(P>0.05).Conclusion:CTVRandMPRimagingwerefoundtobebetterabletoshowthewholeossicularchainintheconductivehearinglosswithnormaltympanicmembranes.Furthermore,theuseofthesetechniquescanhaveprofoundcontributivevalueinthedifferentialdiagnosisofotosclerosisandossicularchainabsenceormalformation.