简介:Objective:toobserveeffectofendothelin-1(ET-1)onhepaticdamageinducedbyendotoxin.Methods:atotalof90ratswererandomlydividedintocontrolgroup(groupc),endotoxintreatedgroup(groupLPS)andendotoxinplusET-1antibodytreatedgroup(groupLEA).AnobservationwasdoneonthechangesofET-1concentration,andtranscriptionandexpressionofET-1mRNA.Plasmaglutamicpyruvictransaminaseenzyme(GPT),hepaticlactatedehydrogenase(LDH),adenosinetriphosphate(ATP)andmalondialdehyde(MDA)werealsoobservedat3,6,9,12,24hoursaftersaline,endotoxin(10mg·kg^-1)andET-1antibody(dalubine1:2000,2ml·kg^-1)administration.Results:TheresultsindicatedthattheconcentrationofplasmaandhepaticET-1andexpressionofET-1mRNAinliversignificantlyincreasedfollowingendotoxemia.ThehepaticET-1levelswereinverselycorrelatedwiththeATPconcentration,andpositivelyrelatedtotheMDAconcentration.ET-1antibodycouldpartiallyprotecttheliveragainstdamageinducedbyendotoxin.Conclusions:Theseresultssuggestthatendotoxinmay,ontranscriptionandtranslationlevel,leadtoanincreaseofET-1insynthesis.ET-1maycontributetohepaticdamageduringendotoxemia.
简介:<正>1病例摘要患者,女,年龄59岁,因高血压3年,双下肢水肿2年,于2009年5月10日收入本院泌尿微创科。患者3年前无明显诱因出现头晕,测血压最高达180/110mmHg,伴有面部皮肤发红,皮肤易出现瘀斑,于当地医院就诊,给予硝苯地平、卡托普利等药物治疗,血压控制可,2年前出现双足肿胀,伴有胸闷、四肢无力、乏力,于当地县医院就诊,诊为"冠心病",给予患者"山枚胶囊"治疗,效果不佳,1年前患者双足肿胀加重,伴有向心性肥胖、四肢肌萎缩、皮肤菲薄、入睡困难,于当地医院就诊,行腰椎CT检查示胸6、7、8、11及12椎体压缩性
简介:摘要阴道壁平滑肌瘤是临床较少见的一类疾病,该病绝大多数发生于育龄期妇女,临床表现隐匿,可无明显症状,多为常规体检时发现。若肿瘤较大症状明显时则应手术治疗。现将我院临床工作中发现的一例该病与大家分享。