简介：[ 摘要 ] 目的；评价 9S 管理在消毒供应中心的应用情况。方法； 我科 从 2019 年 3 月 -2020 年 3 月消毒供应中心 全面实施 9s 管理理念，在 6 个月、 1年后对实施 9S 管理 取得效果进行汇总评价 ， 9s 管理在消毒供应中心的推广是可行。 现将做法和实施细则汇 报如下。

简介：摘要目的探讨在新式剖宫产术中徒手取胎困难时应用中号S拉钩助娩的临床效果；方法对158例在新式剖宫产术中发生徒手取胎困难的单胎头位的产妇应用中号S拉钩助娩；结果158例徒手娩出胎头失败者应用中号S拉钩助娩均成功,其中新生儿窒息率12.0%,新生儿损伤率3.6%,产妇并发症率25.3%；结论在新式剖宫产术中应用中号S拉钩助娩,可安全的娩出胎头，减少手术并发症。

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简介：摘要目的探讨老年人Colle’s骨折手法复位、小夹板或石膏夹板固定，配合患肢功能锻炼的疗效。方法对150例老年人Colle’s骨折，运用手法复位、小夹板或石膏夹板固定，配合患者主动功能锻炼。结果参照1975年全国骨科会议制订的《骨折疗效标准草案》评定，150例中，优91例，占60.7%；良47例，占,31.3%；尚可10例，占,6.7%；差2例，占1.3%；优良率92.0%。结论老年人Colle’s骨折，运用手法复位、小夹板或石膏夹板固定，配合患肢功能锻炼，可取得满意的疗效。

简介：摘要目的探索S拉钩在阴道试产失败中转剖宫产病例中的临床效果。方法选取2013年1月至2016年8月期间我院收治的30例阴道试产失败中转剖宫产产妇，将产妇动态随机化分为两组，两组产妇各有15例，对照组和观察组分别采用传统剖宫术和s拉钩辅助剖宫术。结果观察组产妇的术中出血量（164.35±10.84）ml、手术时间（35.69±3.95）min、子宫切口延伸发生率（6.67%）、新生儿窒息发生率（0.00%）、子宫切口裂伤发生率（6.67%）、产后24小时疼痛评分（3.05±1.65）分、产后48小时疼痛评分（1.05±0.98）分、产后72小时疼痛评分（0.56±0.36）分均优于对照组产妇（P＜0.05）。结论S拉钩在阴道试产失败中转剖宫产病例中效果显著。

简介：【摘要】 目的 分析6s管理在物质管理中的应用价值。方法 抽选来自2017年4月至2018年4月期间我院未实施6s管理的物质管理作为对照组，将2018年5月至2019年5月期间我院采用实施6s管理的物质管理作为观察组 ，比较两组出现物品存放不合理例数、寻找物品消耗时间、清洁环境耗时、月盘点耗时。结果 观察组物品存放不合理例数显著低于对照组，差异具有统计学意义，P＜0.05；观察组寻找物品消耗时间、清洁环境耗时、月盘点耗时显著短于对照组，差异具有统计学意义，P＜0.05。结论 对物质管理中采用6s管理，能够避免不良事件，有助于物品核对，减少物品存放不合理例数，缩短寻找物品消耗时间、清洁环境耗时、月盘点耗时间，在临床上显示出卓越成效，值得进一步推广使用。

简介：【摘 要】目的：有针对性的探究在临床护理过程中应用6S管理所呈现出的应用价值和护理效果。方法：本次研究中所涉及的对象，是选自于我们医院在2018年10月到2020年6月时间范围之内所接收的80例住院患者，按照数字随机的方法对其进行分组，分为对照组和观察组，两组各有患者40例。针对对照组给予常规护理管理措施，而针对观察组给予6S管理模式，对两组患者进行相对应的护理管理之后，对其护理满意程度和治疗总有效率等相关情况进行分析对比。结果：通过对比能够显著看出，观察组患者的治疗总有效率以及护理满意程度等相关情况，要显著地优于对照组，（P＜0.05）。结论：针对临床住院患者来说，在对其进行护理过程中，结合患者的实际情况，有针对性的落实6s管理模式能够呈现出良好的治疗效果，这种护理方法有十分理想的临床应用价值，可以使患者的治疗总有效率和护理满意程度得到显著提升，改善其生活质量，因此这种方法值得在实践的过程中推行和应用。

简介：<正>57例患者分实验组29例,每日静滴丁咯地尔200mg,连续14天;另外28例除不用丁咯地尔外,余治疗同实验组。结果:两组S-100β蛋白和神经元特异性烯醇酯(NSE)水平在治疗前无显著性差异;S-100β蛋白在治疗后第3、7和14天实验组明显低于对照

简介：AbstractTraumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved. Increasing evidence shows that TBI may increase the risk of mood disorders and neurodegenerative diseases, including Alzheimer's disease (AD). However, the complex relationship between TBI and AD remains elusive. Metabolic dysfunction has been the common pathology in both TBI and AD. On the one hand, TBI perturbs the glucose metabolism of the brain, and causes energy crisis and subsequent hyperglycolysis. On the other hand, glucose deprivation promotes amyloidogenesis via β-site APP cleaving enzyme-1 dependent mechanism, and triggers tau pathology and synaptic function. Recent findings suggest that TBI might facilitate Alzheimer's pathogenesis by altering metabolism, which provides clues to metabolic link between TBI and AD. In this review, we will explore how TBI-induced metabolic changes contribute to the development of AD.

简介：Parkinson’sdisease(PD)isanage-relatedneurodegenerativedisordercharacterizedbytypicalmotorsignsandsymptomsthatareduetodopamine(DA)depletioninthebasalganglia.ThetreatmentofPDissymptomatic,andaimsatreplacingthelostDAinputusingeitherL-DOPAorDAagonists.ThecausesofPDareunknownin

简介：SubthalamicnucleusdeepbrainstimulationhasbecomeastandardneurosurgicaltherapyforadvancedParkinson’sdisease.Subthalamicnucleusdeepbrainstimulationcandramaticallyimprovethemotorsymptomsofcarefullyselectedpatientswiththisdisease.Surprisingly,somespecificdimensionsofqualityoflife,"psychological"aspectsandsocialadjustmentdonotalwaysimprove,andtheycouldsometimesbeevenworse.Patientsandtheirfamiliesshouldfullyunderstandthatsubthalamicnucleusdeepbrainstimulationcanalterthemotorstatusandtimeisneededtoreadapttotheirnewpostoperativestateandlifestyles.Thispaperreviewstheliteraturesregardingeffectsofbilateralsubthalamicnucleusdeepbrainstimulationonsocialadjustment,qualityoflifeandcopingstrategiesinpatientswithParkinson’sdisease.ThefindingsmayhelptounderstandthepsychosocialmaladjustmentandpoorimprovementinqualityoflifeinsomeParkinson’sdiseasepatients.

简介：目的评估A型肉毒毒素治疗Meige’s综合征的疗效。方法对A型肉毒毒素治疗的30例Meige’s综合征患者资料进行回顾性分析。结果30例Meiges’s综合征患者注射A型肉毒毒素后25例完全缓解，5例明显缓解，总有效率100％。起效时间注射当天～第3天。疗效维持平均为5个月。重复治疗有效。局部不良反应轻微、短暂、可逆，无全身不良反应及过敏反应。结论A型肉毒毒素局部注射是治疗Meige’s综合征的一种安全、有效、简便、易行的方法。

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简介：AbstractPurpose:To investigate the orthopedic injuries sustained while driving and using social media on cellular phones from an orthopedic resident's perspective.Methods:A total of 118 patients who presented with a history of road traffic accident secondary to social media usage and suffered from fractures were included in this cross-sectional study. These patients were reported from October 2018 to April 2019. We collected the data including the type of collision, type of social media usage during driving, location of injury, wearing of safety equipment's such as helmet and seat belt during driving.Results:The mean age of patients was (34.86 ± 12.73) (range 15-71) years. The common types of accident on the basis of collision of vehicles were: car versus motorbike 45 (38.1%), motorbike versus motorbike 28 (23.7%), and motorbike versus pedestrian 22 (18.6%). Most of the accidents (61, 51.7%) occurred due to mistake of motor-bikers. Out of them, 44 (37.3%) occurred on traffic signals, followed by 29 (24.6%) while driving on main roads. The common timing of accident was normal hours with frequency of 44 (37.3%), followed by 39 (33.1%) at late night. According to fracture type, closed injuries were 98 (83.1%) and open fractures were 20 (16.9%). The most common fracture was clavicular fracture (21, 22.5%) followed by soft tissue injury in 19 (16.1%) patients. The most common social media application usage during driving was Facebook 43 (36.4%), followed by Whatsapp 24 (20.3%), Google 19 (16.1%), and Instagram 15 (12.7%).Conclusion:This study provides evidence that social media usage while driving put the drivers and other road users' lives at high risk. The most common social media addiction while driving is Facebook and Whatsapp. So there is a need to make strict rules and penalties for using cell phone during driving so as to save the lives of drivers and other people using road.

简介：摘要目的实施“5S”服务，主要给患者提供安全，优质，满意的护理服务。方法具体方法；看见病人站起来（Stand）、用眼睛注视着对方（See）、对患者展开微笑（Smile）；迅速的回答患者的问题（Speed）；让患者满意（Satisfaction）。（简称“5S”）的护理服务。结果从实施“5S”服务以来的护理工作满意度丛89%上升到96%。结论“5S”服务后，大大提高了护理工作满意度为医院取得了较好地社会效益及经济效益。

简介：Castleman’S病（CD）属原因未明的反应性淋巴结病之一，临床较为少见，1956年由Castleman首先报道。由于对本病认识不深，临床上容易漏诊、误诊。我科收入1例慢性肾衰竭患者，为CD侵犯腹腔淋巴结，肿大淋巴结及后腹膜纤维化局部压迫引起梗阻性。肾病，肾损表现以小管损害为主，现报道如下。

简介：Psoriasin(S100A7)是一种分子量为22.9kD的同源二聚体蛋白,属于S100蛋白家族成员。通过与钙离子结合,参与细胞内外重要的生命活动。其基因定位于染色体1q21.2-q22。Psoriasin(S100A7)蛋白最初是从银屑病异常增生的角化细胞中分离得到的,故称为Psoriasin,即银屑素。Psoriasin在异常增生的角化细胞、膀胱鳞状细胞癌和原位及浸润乳腺癌中表达上调。Psoriasin这种分泌和表达特征有可能作为膀胱鳞状细胞癌和乳腺癌等恶性肿瘤的候选标志物。

简介：Leber'scongenitalamaurosis(LCA)andrecentgenetherapyadvancementfortreatinginheritedretinopathieswereextensiveliteraturereviewedusingMEDLINE,PubMedandEMBASE.Adeno-associatedviralvectorswerethemostutilisedvectorsforoculargenetherapy.Conephotoreceptorcellsmightuseanalternatepathwaywhichwasnotreliantoftheretinalpigmentepithelium(RPE)derivedretinoidisomerohydrolase(RPE65)toaccessthe11-cisretinaldehydechromophore.Researcheffortsdedicatedontheprogressionofagene-basedtherapyforthetreatmentofLCA2.Suchgenetherapyapproacheswereextremelysuccessfulincanine,porcineandrodentLCA2models.TherecombinantAAV2.hRPE65v2adenoassociatedvectorcontainedtheRPE65cDNAandwasreplicationdeficient.ItsinvitroinjectionintargetcellsinducedRPE65proteinproduction.Thegenetherapytrialsthatweresofarconductedforinheritedretinopathieshavegeneratedpromisingresults.PhaseIclinicaltrialstocureLCAandchoroideremiademonstratedthatadeno-associatedviralvectorscontainingRPEgenesandphotoreceptorsrespectively,couldbesuccessfullyadministeredtoinheritedretinopathypatients.AphaseIIItrialispresentlyongoingandifsuccessful,itwillleadthewaytoadditionalgenetherapyattemptstocuremonogenic,inheritedretinopathies.