简介：目的：观察艾灸预处理对急性胃黏膜损伤大鼠胃黏膜细胞凋亡相关因子的影响，探讨艾灸诱导HSP70与上述因子的关系，从细胞凋亡线粒体信号转导途径探讨艾灸预处理保护胃黏膜损伤的机制。方法：将32Wister大鼠随机分为4组，即捆绑组、模型组、艾灸穴位组、艾灸非穴组。艾灸穴位组和艾灸非穴组大鼠艾灸预处理8d，捆绑组和模型组大鼠只捆绑，不艾灸。除捆绑组外，其余各组制备大鼠急性胃黏膜损伤模型。采用Western—blot方法检测大鼠胃黏膜细胞色素C（Cyt—c）的表达，免疫组织化学方法检测胃黏膜HSP70，胃黏膜细胞凋亡，Apaf-1，Caspase-9，Caspase-3，Bcl-2和BaX的表达。结果：与捆绑组相比，模型组大鼠胃黏膜HSP70表达，胃黏膜细胞凋亡指数，胞浆Cyt—C，Apaf-1，Caspase-9，Caspase-3，Bcl-2和Bax含量明显增加（P〈0．05或P〈0．01）。与模型组相比，艾灸穴位组大鼠胃黏膜HSP70表达和Bcl-2明显增加（P〈0．01），而细胞凋亡指数，胞浆Cyt—C，Apaf-1，Caspase-9，Caspase-3，Bax均显著降低（P〈0．01）。与艾灸穴位组相比，艾灸非穴组大鼠胃黏膜HSP70表达和Bcl-2显著降低（P〈0．01），而凋亡指数，Cyt—c，Apaf-1，Caspase-9，Caspase-3，Bax显著升高（P〈0．05或P〈0．01）。结论：艾灸通过上调大鼠胃黏膜细胞HSP70表达，并影响细胞凋亡线粒体信号转导途径相关因子Cyt—C，Apaf-1，Caspase-9，Caspase-3，Bcl-2和Bax，由此抑制胃黏膜细胞凋亡，达到保护胃黏膜损伤的作用。

简介：Toinvestigatetheeffectsofsimvastatinonmembraneioniccurrentsinleftventricularmyocytesofrabbitheartsufferingfromacutemyocardialinfarction(AMI),soastoexploretheionicmechanismofstatintreatmentforantiarrhythmia.MethodsForty-fiveNewZealandrabbitswererandomlydividedintothreegroups:AMIgroup,simvastatininterventiongroup(Statingroup)andsham-operatedcontrolgroup(CON).Rabbitswereinfarctedbyligationoftheleftanteriordescendingcoronaryarteryafteradministrationoforalsimvastatin5mg·kg-1·d-1(Statingroup)orplacebo(AMIgroup)for3days.Singleventricularmyocyteswereisolatedenzymaticallyfromtheepicardialzoneoftheinfractedregion72hlater.Wholecellpatchclamptechniquewasusedtorecordmembraneioniccurrents,includingsodiumcurrent(INa),L-typecalciumcurrent(ICa-L)andtransientoutwardpotassiumcurrent(Ito).Results①Therewasnotsignificantdifferenceinserumcholesterolconcentrationamongthreegroups.②ThepeakINacurrentdensity(at-30mV)wassignificantlydecreasedinAMIgroup(-25.26±5.28,n=13),comparingwithCON(-42.78±5.48,n=16),P<0.05,whileitwassignificantlyincreasedinStatingroup(-39.83±5.65pA/pF,n=12)comparingwithAMIgroup,P<0.01;ThepeakICa-Lcurrentdensity(at0mV)wassignificantlydecreasedinAMIgroup(-3.43±0.92pA/pF,n=13)comparingwithCON(-4.56±1.01pA/pF,n=15),P<0.05,whileitwassignificantlyincreasedinStatingroup(-4.18±0.96pA/pF,n=12)comparingwithAMIgroup,P<0.05;TheItocurrentdensity(at+60mV)wassignificantlydecreasedinAMIgroup(11.41±1.94pA/pF,n=13)comparingwithCON(17.41±3.13pA/pF,n=15),P<0.01,whileitwassignificantlyincreasedinStatingroup(16.11±2.43pA/pF,n=14)comparingwithAMIgroup,P<0.01.ConclusionsAMIinducessignificantdown-regulationofINa,ICa-LandIto.Pretreatmentwithsimvastatincouldattenuatethischangewithoutloweringtheserumcholesterollevel,suggestingthatsimvastatincouldrev

简介：摘要BACKGROUNDCorona Virus Disease-2019 (COVID-19) is an acute respiratory infectious disease. Despite being clinically cured, some patients still find it difficult to return to their normal life and work due to the degree of dysfunctions that they have, as part of the disease′s aftereffect. Through this study, we aim to learn more about the dysfunctions and rehabilitation needs of COVID-19 patients.METHODSIn this survey, the basic information, dysfunctions, and rehabilitation needs of the hospitalized COVID-19 patients, who were selected by convenience sampling in Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine, were obtained using a self-designed questionnaire. The research was conducted from February 29, 2020 to March 2, 2020.RESULTSA total of 280 patients were finally included, who were mainly over 51 years of age (64.2%). The main physical dysfunctions that the patients had were sleep disorders (63.6%), decreased activity endurance (61.4%), and respiratory dysfunction (57.9%), while the main psychological dysfunctions included anxiety (62.1%) and fear (50.0%). Rehabilitation that mainly requested by the patients included exercise guidance, dietary instruction, traditional Chinese medicine therapy, physical therapy, and Chinese traditional health exercises.CONCLUSIONSThe demand for rehabilitation is high among COVID-19 patients, which requires the quick establishment of a comprehensive and individualized rehabilitation program, to be fulfilled.

简介：Pheochromocytomaisatumorarisingfromneuroectodermalchromaffintissuesintheadrenalglandorextra-adrenalparaganglia(paragangliomas).Theprevalenceofthetumoris0.1%-0.6%inthehypertensivepopulation,ofwhich10%-20%aremalignant.Pheochromocytomaproduces,stores,andsecretescatecholamines,aswellasleadstohypertensivecrisis,arrhythmia,angina,andacutemyocardialinfarctionwithoutcoronaryarterydiseases.Wereportacaseofacutecoronarysyndrome(ACS)withafinaldiagnosisofmultipleendocrineneoplasiawithpheochromocytomaandmedullarythyroidcarcinoma(MTC).

简介：ObjectivesThepurposeofthisstudywastodetermineiftheultrasonicintegratedbackscatterandechointensitycouldbeusedinclinicaldiagnosisofacutemyocardialinfarction.MethodsandResultsWithin2weeksafteracutemyocardialinfarction,35patientsunderwentultrasonictissuecharacterizationfromthepapillaryshort-axisview.Thecyclicvariationofintegratedbackscatterandechointensityofthreedifferentmyocardialregionsperfusedbyleftanteriordescendingcoronaryartery,leftcircumflexcoronaryandrightcoronaryweremeasured.Thevalueofcyclicvariationofintegratedbackscatterandintegratedbackscatterandechointensity≤halfofthehighestvalueofthreedifferentmyocardialregionsonasameviewweredefineasthecriteriafordiagnosingacutemyocardialinfarction,andtheresultswerecomparedwithcoronaryangiography.ThesensitivityofdiagnosingacutemyocardialinfarctionbybothUltrasonictissuecharacterizationwithintegratedbackscatterandechointens

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简介：Purpose:ThepurposeofthisstudywastoinvestigatetheimpactofacuteexerciseonreactiontimeandresponsepreparationduringaGo/NoGoTaskinchildrenwithattentiondeficithyperactivitydisorder(ADHD).Methods:NineteenchildrenwithADHD(agedbetween8and12yearsold)undertooka30-mininterventionthatconsistedoftreadmillrunningorvideo-watchingpresentedinacounterbalancedorderondifferentdays.AGo/NoGoTaskwasadministratedafterexerciseorvideo-watching.Results:Theresultsindicatedashorterreactiontimeandsmallercontingentnegativevariation(CNV)2amplitudefollowingexerciserelativetothevideo-watching.Foreventrelatedpotential(ERP)analyses,greaterCNV1andCNV2amplitudesinresponsetoNoGostimuliincomparisontoGostimuliwasobservedinthevideo-watchingsessiononly.Conclusion:ThesefindingssuggestthatacuteexercisemaybenefitchildrenwithADHDbydevelopingappropriateresponsepreparation,particularlyinmaintainingastablemotorpreparatorysetpriortoperformingthegiventask.

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简介：Objective:Toobservethetherapeuticeffectofelectroacupuncture(EA)onplasmaangiotensin(Ang*.Ⅱ),aldosterone(ALD)andatrialnatriureticpolypeptide(ANP)contentsinexperimentalcerebralinfarctionrabbitsforanalyzingtheunderlyingmechanismofacupunctureinamelioratingbloodsupplyofthebraintissue.Methods:Atotalof80rabbitswererandomizedintocontrol(n=8),pseudo-operation(n=24),model(n=24)andEA(n=24)groups.Cerebralinfarctionmodelwasestablishedbyinfusionofself-thrombusintothecarotidartery.EA(1mA,2Hz)wasappliedto'Baihui'(百会GV20)and'Shuigou'(水沟GV26)for30min,onceevery12hours.PlasmaAng-II,ALDandANPcontentsweredetectedwithradioimmunoassaymethod.Inthelater3groups,bloodsamplesweretakenat6h,24hand48haftercerebralischemia.Results:Comparedwithcontrolandpseudo-operationgroups,Ang-IIandALDcontentsofmodelgroupat6h,24hand48haftercerebralischemiaincreasedsignificantlywhileplasmaANPofthe3time-coursesofmodelgroupdecreasedconsiderably(P<0.01).Incomparisonwithmodelgroup,resultsshowedthatAng-IIandALDcontentsofEAgroupdecreasedsignificantlywhereasANPlevelofEAgroupincreasedstrikingly(P<0.01).Conclusion:ElectroacupuncturehastheeffectsofraisingplasmaANPlevelandloweringplasmaAng-IIandALDincerebralinfarctionrabbits.

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简介：AbstractCoronavirus disease 2019 is a major threat to public health globally. Though its pathogenesis has not been fully elucidated, angiotensin-converting enzyme 2 (ACE2) has been recently identified as a receptor for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the cell. Here, we aimed to clarify the potential role of ACE2 in SARS-CoV-2-induced acute lung injury and its underlying mechanism. As a receptor for coronavirus, ACE2 mediates the entry of SARS-CoV-2 into cells in a similar way as for severe acute respiratory syndrome coronavirus (SARS-CoV). The high binding affinity of SARS-CoV-2 to ACE2 correlates with its efficient spread among humans. On the other hand, ACE2 negatively regulates the renin-angiotensin-aldosterone system (RAAS) primarily by converting angiotensin II to angiotensin 1-7, which exerts a beneficial effect on coronavirus-induced acute lung injury. Human recombinant ACE2 has been considered as a potential therapy for SARS-CoV-2 by blocking virus entry and redressing the imbalance of RAAS in SARS-CoV-2 infection. The level of ACE2 expression can be upregulated by treatment with an ACE inhibitor (ACEI) or angiotensin II type 1 receptor blocker (ARB). To date, no evidence shows that ACEIs or ARBs increase the susceptibility and mortality of patients infected with SARS-CoV-2, and hence, it is not advisable to discontinue such drugs in patients with cardiovascular disease.

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简介：AbstractSince October 2021 in Alabama, the United States, and March 2022 in central Scotland, the United Kingdom, the number of cases of severe acute hepatitis of unknown etiology/causes in children was found to increase, and the total number of cases has reached 920 worldwide by June 22 this year, 45 cases (5%) required liver transplantation, and 18 cases (2%) died according to World Health Organization (WHO). To understand the basic characteristics of this disease/syndrome, a literature search was performed at PubMed, websites of WHO, UK Health Security Agency, and US and European Centers for Disease Control and Prevention, and more than 20 reports were enrolled as references for this review. The main clinical manifestations are anorexia, vomiting, fatigue, jaundice, and so forth. Most of the cases seemed to have a self-limited course of the disease, about 6% of cases may develop life-threatening acute liver failure. The disease seems to be transmissible from person to person. Human adenovirus was detected in up to 75% of cases, but this virus seems not to be the only and major etiologic agent, other cofactors probably are involved. Researchers proposed many hypotheses concerning the etiology and pathogenesis, and many important works and studies are ongoing. This mini-review is aimed at summarizing, reviewing, and further understanding the characteristics of the disease, raising some clinically relevant questions, and trying to discuss some questions that may be related to the treatment of the disease for consideration.

简介：Purpose:Thepurposeofthisstudywastodeterminetheeffectsofacuteexerciseonmotorresponseinhibitionusingbothbehavioralandelectrophysiologicalapproaches.Methods:TheP3andN1event-relatedpotential(ERP)componentswererecordedwhileperformingastop-signaltaskin21collegestudentsfollowingamoderatelyintenseacuteexerciseboutfor30minandasedentarycontrolsessionthatinvolvedreading.Results:Acuteexerciseinducedashorterstopsignalresponsetime(SSRT)ascomparedtocontrol;however,thegoresponsetime(GoRT)remainedunchanged.InexaminingtheERPdata,acuteexerciseincreasedbothP3amplitudeandlatencybutdidnotaffecttheN1component.Conclusion:Acuteexercisehasaselectiveandbeneficialeffectoncognitivefunction,specificallyaffectingthemotorresponseinhibitionaspectofexecutivefunction.Furthermore,acuteexercisepredominatelyimpactslaterstagesofinformationprocessingduringmotorresponseinhibition,whichmayleadtoanincreaseinattentionalresourceallocationandconfertheabilitytosuccessfullywithholdaresponsetoachievemotorresponseinhibition.

简介：尖锐的圣举起心肌的梗塞有高死亡和病态率。有这张条件脸的病人的多数除了另外的健康问题的可勃起的机能障碍。在这研究，我们试图调查二不同灌注策略，主要angioplasty和thrombolytic治疗的效果，在在尖锐心肌的梗塞以后的可勃起的机能障碍的流行上。匹配选择标准的71个病人，45与stenting与主要冠的angioplasty被对待，并且26与thrombolytic代理人被对待。可勃起的功能在医院里用可勃起的功能的国际索引被评估在事件以后在尖锐心肌的梗塞和6个月前描绘每个病人的性功能。要求恢复血流动到梗塞影响的动脉的时间被发现在尖锐心肌的梗塞以后与可勃起的机能障碍的出现被联系。在尖锐心肌的梗塞以后的可勃起的机能障碍的流行的增加是44.4%；在angioplasty组和76.9%；在thrombolytic治疗组(P=0.008)。在结论，这研究显示出那减少灌注减少的时间可勃起的机能障碍流行，和主要angioplasty比为减少的thrombolytic治疗优异在尖锐心肌的梗塞以后的可勃起的机能障碍的流行。

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简介：Acuteaorticsyndromeincludesclassicaorticdissection,aorticintramuralhematoma,andpenetratingatheroscleroticulcer–agroupofconditionsthataredefinedbytheirdynamicevolutionandsimilarclinicalmanifestation.Accuratediagnosisandprompttreatmentareessentialasalltheaforementionedconditionsareasignificantthreattoapatient’slife.However,acuteaorticsyndromeandespeciallyaorticintramuralhematomamaybechallengingdiagnosticproblems.Intravascularultrasoundimagingisadiagnosticmethodthatcanbeusefulformorethoroughevaluationoftheaorticlesionandcanparticularlyaidindiscerningthedifferentformsofacuteaorticsyndrome.Wepresentacaseofapatientwithaorticintramuralhematomathatwasmissedbyconventionalimagingstudiesbutwassuccessfullyvisualizedwithintravascularultrasoundimaging.

简介：ObjectivesTocomparethedifferentpatternsofcoronaryarterycalcification(CAC)inacuteandchroniccoronarysyndromesutilizingelectronbeamcomputedtomography.BackgroundPathologic,angiographic,andintracoronaryultrasoundstudiesrevealedsharpdifferencesintheplaquemorphologybetweenpatientswithacuteversuschroniccoronarysyndromes.Whethertherearedifferentpatternsofcoronaryarterycalcificationinpatientswithstableanginapectoris(SAP)andinthosewithunstableanginapectoris(UAP)oracutemyocardialinfarction(AMI),however,remainsunclear.MethodsTwohundredandsixty-fourpatients,including67withSAP,94withUAPand103withAMIwerestudiedwithelectronbeamcomputedtomographyforanalysisofcoronaryarterycalcificationandwithselectivecoronaryangiographyfordeterminationofatheroscleroticlesions.CACprevalenceandcalciumscorewerecomparedamongthreegroups,andrelationofCACtotheseverityofatheroscleroticdiseaseintheSAPandUAP

简介：ObjectivesTostudythestatusoffibrinolyticinhibitioninpatientsofacutecoronarysyndrome(ACS)complicatedwithtypeⅡdiabetesmellitus(NIDDM)andtoevaluatetheeffectoffibrinolyticinhibitiontotheclinicalprognosis.MethodsTypeⅡdiabetesmellituswasdefinedbyADA1997/WH01998criteria.Thesubjectsweredividedintotreatmentgroupsthatincluded39patientsofACSwith20casesofacutemyocardiacinfarction(AMI),36patientsofACS+NIDOMwith20casesofAMI.Twentycasesofhealthypeoplewererandomizedtocontrolgroup.Theplasmaleveloftissuetypeplasminogenactivator(t-PA),plasminogenactivatorin-hibitortype-1(PAI-1)andplasmaD-dimerweredetectedbyusingelisatechnique.TheindexofstatueinfibrinolysiswasdetectedwiththeplasmalevelofD-dimerandtherateofPAI-1/D-dimerinpercentage.ThisindexwasusedtoevaluatethefibrinolyticinhibitionandtheclinicaloutcomeinallthepatientswithAMIintreatmentgroups.TheclinicaloutcomeinpatientswithAMIconsistedoftherateofreperfusion,theincidencesofreinfarction,severi-ousarrhythmia,pumpfailureanddeathintheearlyperiodofAMI.ResultsTheplasmalevelofPAI-1andD-dimerwashigherinthetwotreatmentgroupsthanthatinthecontrolgroup(P<0.01).TheplasmalevelofPAI-1significantlyhigherinACS+NIDDMpatientsthanthatinACS(P<0.05),buttheplasmalevelofD-dimerraisedfrombasiclevelwassignificanflylowerinACS+NIDDMthanthatinACS(P<0.05).TherateofPAI-1/D-dimerinpercentagewassignificantlyhigherinACS+NIDDMthanthatinACSorincontrolgroup(P<0.01).ForAMIpatientsintwotreatmentgroups,therateofreperfusionafterthethrorabolytictherapywassignifi-candylowerinACS+NIDDMthanthatinACS(P<0.01).TherateofincidencesinpumpfailurewassignificantlyhigherinACS+NIDDMthanthatinACStoo(P<0.05).Themorbidityofseveriousarrhythmia,re-infarctionandthemortalitywerealsohigherinACS+NI