简介:目的探讨化疗加放疗治疗N2、N3期鼻咽癌的价值。方法90例N2、N3期鼻咽癌随机分为放疗化疗组(放化组)和单纯放疗组(单放组)。结果放疗化疗疗组和单纯放疗组近期鼻咽部肿瘤完全消退率分别为91.8%和84.0%(P〈0.05);两组颈部淋巴结转移灶完全消退率为83.8%和64.9%(P〈0.05)。两组3、5年鼻咽部肿瘤控制率分别68.3%和43.6%(P〈0.05),54.8%和36.1%(P〈0.05);两组颈部淋巴结转移灶控制率分别是64.7%和40.90k(P〈0.05),54.1%和35.2%(P〈0.05):两组3、5年的远处转移率分别是19.9%和42.9%(P〈0.05),28.9%和48.9%(P〈0.05);两组3、5生存率分别是56.7%和32.9%(P〈0.05),45.5%和25.9%(P〈0.05)。放疗化疗组的消化道反应、血液毒性均高于单纯放疗组(P〈0.05),但病人可以耐受。结论同步放化疗治疗N2、N3期鼻咽癌有助于提高生存率,减少局部复发和远处转移。
简介:N-acetyl-D-methionine,NaAcandtheremainsofN-acetyl-L-methioninedramaticallyaffectthepurificationofL-methioninewhenpurifiedfromthemixtureofenzymaticallydeacylatedN-acetyl-DL-methionine,leadingtoalowyieldconventionally.Here,thispaperreportsasuccessfulseparationandpurificationofbothL-methionineandN-acetyl-D-methioninebyanHion-exchangecolumn.ThepH,L-Metconcentrationandtheratiobetweenthecontentofsodiumcationandtheion-exchangecapacitywereoptimizedtoobtainthemaximumyield.Experimentalresultsindicatethat,undertheoptimizedconditions,theyieldsofL-methionineandN-acetyl-D-methioninecanreachashighas85%and75%,respectively.
简介:Thecrystalandmolecularstructureofcopper(Ⅱ)dimericcomplexofS-methyl-B-N-(pyridineN-oxide-2-ylmethylidene)dithiocarbazatewithacetonitrile,[CuL(CH3CN)]2(ClO4)2,wasdeterminedbyX-raydiffraction.ThecomplexcrystalizesinmonoclinicsystemwithspacegroupP21/n,a=7.685(2),6=20.160(6),c=10.847(5)A,B=107.89(3),Z=2,Dc=1.788g/cm3,F(000)=835.8,u=18.17cm-1(Moka,R=0.057.EachCu(Ⅱ)ioninthecomplexissurroundedbyadistortedsquarepyramidal.ThebasalplaneiscomprisedofS,NandOatomsofoneligandtogetherwithaNatomofthesolvent--acetonitrile,whiletheaxialpositionisoccupiedbytheSatomoftheotherligand.ThebondlengthofCu-S(bridging)is3.038A.andCu-Cudistanceis3.700A.
简介:合成了N,N′-亚水杨基皮考林酰肼(HL)及其铁配合物[FeL2](C26H20FeN6O4,Mr=536.33).X射线衍射实验结果表明,标题配合物晶体属于正交晶系,空间群为Pbcn,晶体学参数:a=1.4970(1)nm,b=1.51556(9)nm,c=2.0920(2)nm,V=4.7462(6)nm3,Z=8,Dc=1.501Mg·m-3,F(000)=2208,μ(MoKα)=0.682mm-1,R=0.0695,Rw=0.1502.在配合物[FeL2]中,铁(Ⅱ)原子具有扭曲的八面体配位构型,晶体通过分子间氢键作用形成缔合分子对.红外光谱表明,配体在形成配合物后,ν(CO)和ν(CN)红移.电子光谱表明存在π-π*和d-π*的跃迁;荧光光谱表明,配合物金属对配体n-π*激发引起的荧光发射峰有较大的影响.
简介:Theinteractionsofoxidativeradicals(Br2,HOetc.)withN-phosphoryldipeptidederivatives(NDM-TrpOMeandNDT-MetOMe)havebeeninvestigatedbyusingpulseradiolysisatdifferentpHvalues.IthasbeenfoundthatBr2andHOradicalsoxidizetheMet-siteandTrp-siteinthedipeptidederivativesviaformationofthethree-electron-bondedintermediateandindolylradicalsimultaneously.Thentheintramolecularelectrontransferalongthepeptidebackboneoccurs.Therateconstantsofelectrontransfer,k,havebeendeterminedandthereactionmechanismhasbeendeduced.
简介:想必校园MM们都有被男生追的经历吧!如果他是你的梦中情人倒也罢,可如果不是,那么如何拒绝就是考验你的时刻了,该怎么说?怎么做?是否有效?如果你正被这个问题困扰,那么就来听听大家的说法吧!
简介:Theemploymentofboth"bipartite"and"tripartite"nominalsentencepatternscontainingdemonstrativesofthen-seriesinMiddleEgyptian~1showsacharacteristicsufficientlyconsistenttowarrantthesuggestionthatasemanticconstraintisoperative:VIZ.,thatthosesentencesareemployedwithNPsthatare[-PERSON],not[+PERSON].Therefore,sentencessuchas~*R’/it.i/ink(pw)nn/nf(3)/n3/nwareexcluded.Inasentencesuc(?)asbit.ipwn3"Thisismycharacter/conduct"~2,bit.i"mycharacter/conduct"is[-PERSON],whereasonecouldnotsay,e.g.,~*s3.ipwn3"Thisismyson."Accordingtothishypothesis,allMiddleEgyptian