摘要
Atransientpostanaphaserepositioningofthecentrioleisfoundtocontrolthecompletionofcytokinesis.Usingagreenfluorescentprotein-calmodulinfusionproteinasalivingcellprobe,wehavepreviouslyfoundthatcalmodulinisassociatedwiththeinitiationandprogressionofcytokinesis.Inthisstudy,wefurtherstudiedtheeffectofcalmodulinontherepositioningofthecentrioleandsubsequentcellcycleprogression.Whenactivityofcalmodulinisinhibited,theregressionofthecentriolefromtheintercellularbridgetothecellcenterisblocked,andthusthecompletionofcelldivisionisrepressedandtwodaughtercellsarelinkedbylongercellbridgeinperturbedcells.W7treatmentduringcytokinesisalsoresultsinunfinishedcytokinesisandstoppedG1phase.Theseresultssuggestthatcalmodulinactivityisrequiredforcentriolerepositioningandcanaffectthecompletionofcytokinesisandcellcycleprogression.
出版日期
2005年07月17日(中国期刊网平台首次上网日期,不代表论文的发表时间)