Imaging and clinical properties of inflammatory demyelinating pseudotumor in the spinal cord

(整期优先)网络出版时间:2013-12-22
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Inflammatorydemyelinatingpseudotumorusuallyoccursinthebrainandrarelyoccursinthespinalcord.Onimaging,inflammatorydemyelinatingpseudotumorappearsverysimilartointramedullarytumorssuchasgliomas.Itisoftenmisdiagnosedasintramedullarytumorandsurgicallyresected.Inviewofthis,theclinicalandmagneticresonanceimagingmanifestationsandthepathologicalfeaturesof36casesofinflammatorydemyelinatingpseudotumorinthespinalcordwereretrospectivelyanalyzedandsummarized.Mostofthesecasessufferedfromacuteorsubacuteonsetandexhibitedasensorimotordisorder.Amongthem,sixcasesweremisdiagnosedashavingintramedullarygliomas,andinflammatorydemyelinatingpseudotumorwasonlyidentifiedandpathologicallyconfirmedaftersurgicalresection.Lesionsinthecervicalandthoracicspinalcordwerecommon.Magneticresonanceimagingrevealededemaandspace-occupyinglesionstovaryingdegreesatthecervical-thoracicjunction,withapredominantfeatureofnon-closedrosette-likereinforcement(open-loopsign).Pathologicalexaminationshowedperivascularcuffingofpredominantlydenselymphocytes,anddemyelinationwasobservedinsixofthemisdiagnosedcases.Theseresultssuggestthattumor-likeinflammatorydemyelinatingdiseaseinthespinalcordisakindofspecialdemyelinatingdiseasethatcanbecategorizedasinflammatorypseudotumor.Thesesolitarylesionsareeasilyconfusedwithintramedullaryneoplasms.Patchyornon-closedreinforcement(open-ringsign)onmagneticresonanceimagingisthepredominantpropertyofinflammatorydemyelinatingpseudotumor,andinflammatorycellinfiltrationanddemyelinationareadditionalpathologicalproperties.