Bioluminescenceimagingisakindofemergingdetectiontechnologyatcellular,molecularandgeneticlevel.Themostpopularbioluminescenceimagingmodelisdiffusionapproximation(DA).However,becauseoftheill-posednessoftheDA-basedinverseproblemandtheinstabilityofreconstructionalgorithms,thelocationaccuracyofthereconstructedsourcesislow.Radiativetransferequation(RTE),whichconsidersthedirectionofthephotonmigrationandtheeffectofabsorptionandscatteringintissues,canaccuratelyexpressthetransmissionofbioluminescentphotonsthroughthetissues.Inthispaper,westudiedthebioluminescenceimagingbasedontheRTE.2Dsimulationswereperformed,andquantitativeevaluationwasgivenbytheabsolutesourcepositionerror,therelativesourceareaerrorandtheminimumboundingbox.TheresultsoftheexperimentshowedthattheimagingqualitybasedonRTEwasbetterthanthatonebasedonDA.
