Littoral-cellangioma(LCA),aprimaryangiomawhichclinicallybelongstosplenichemangioma,canbemostlyfoundinnormalspleenredsinusshorecellsofreticuloendothelialcellsystem.ThecellsofLCAstronglyexpressendothelialandtissuecellassociatedantigensthatindicateadualdifferentiationcharacteristic;whereasonlyendothelialcellmarkersarepositiveinnormalspleenredsinusshorecells.DiagnosisofLCAreliesonhistopathology.Regularfollow-upisneededtomonitorrecurrenceandmetastasis.
