ThispaperaddressesthesupplychainengineeringanditsapplicationinChina’sretailingindustry.Basedontheapproachesofsystemsengineering,weproposetheconceptofsupplychainengineering,whichappliestheideaofsupplychainmanagementtotheengineeringpracticesthroughtheadvancedinformationandmanagementtechnology,tointegratethesupplychainsystemandoptimizeitsoperations.WethenillustratetheapplicationofthesupplychainengineeringinChina’sretailingindustry.Insuchpractices,wedevelopedthevirtualretailingenterprisemodeandtheFROM-SCMsystem,anddesignedthesalesassistantetc.SuchtheoryandpracticesaresuccessfullyappliedinMeiyijia,whichhastransformedMeiyijiafromatraditionalretailertoamodernserviceenterprise,andtheprofitsareresultedfromtheservicefeesratherthanthetraditionalsurplusbetweenbuyingandsellingprices.NowMeiyijiahasbuiltanecosystemwiththeretailerinthecore,theheadquarterastheserviceplatform.ThesuccessofMeiyijiainrecentyearsshowstheeffectivenessofthesupplychainengineering.