Stripenonuniformityisverytypicalinlineinfraredfocalplane(IRFPA)anduncooledstarringIRFPA.Wedeveloptheminimummeansquareerror(MMSE)methodforstripenonuniformitycorrection(NUC).ThegoaloftheMMSEmethodistodeterminetheoptimalNUCparametersformakingthecorrectedimagetheclosesttotheidealimage.Moreover,thismethodcanbeachievedinoneframe,makingitmorecompetitivethanotherscene-basedNUCalgorithms.Wealsodemonstratethecalibrationresultsofouralgorithmusingrealandvirtualinfraredimagesequences.Theexperimentsverifythepositiveeffectofouralgorithm.