简介：TheannualmeetingoftheHeartFailureAssociationofESCinLisbon,inJune2005,wasexceptionallysuccessful.Thereweremanyveryinterestingpresentationsandworkshopswiththeuniquetitle:StatinsinheartfailureCholesterol-loweringisnottheonlygoalHeartfailure(HF)isaprogressivediseasewithcoronaryarterydisease(CAD)asthemostoftenunderlyingetiology.TreatmenttopreventprogressionofheartfailurehasbeentargetedtoreversetheconsequencesofHFandtoalessextentthecause-theatheroscleroticplaqueitself.Ontheaverage50%ofpatientswithheartfailurearetreatedwithlipidintervention.Lipid-loweringtreatmentwithstatinsclearlyreducesmorbidityandmortalityofpatientswithdocumentedCAD.SincetheprevalentetiologyofheartfailureisCAD,itspreventionmayreduceheartfailureprogression.However,recentstudiessuggestthatpleiotropiceffectsofstatinsaremoreimportantthantheinfluencerelatedtotheircholesterolloweringmechanism.Furthermoreitissuggestedthatlowlevelsofcirculatinglipoproteinsandcholesterolmaybeindependentpredictorsofimpairedoutcomeinpatientswithheartfailure.Therearesomepossibleexplanationsforthisfinding.Highlevelsofcholesterolcanbebeneficialtoheartfailurepatients;cholesterol-richserumlipoproteinsareabletomodulateinflammatoryimmunefunctionbecausetheybindanddetoxifybacteriallipopolysaccharide,averystrongstimulatorofthereleaseofproinflammatorycytokinesthatpromoteheartfailureprogressionanddeath.SocurrentrecommendationsstronglyemphasizethattheaimoftreatmentofHFisnottolowercholesterol.

简介：摘要目的了解本院2019临床分离出的主要病原菌分布及耐药性分析，指导临床医生合理使用抗菌药物，为控制医院感染提供依据。方法采用全自动细菌鉴定/药敏分析仪，对医院各临床科室送检标本分离出的常见细菌分布及药敏结果进行回顾性分析。结果分离病原菌共597份，总的阳性率为7.23%；前五位细菌分别是流感嗜血杆菌（204株）、大肠埃希菌（70株）、肺炎链球菌（67）、金黄色葡萄球菌金黄亚种（41株）、肺炎克雷伯菌肺炎亚种（40），各占34.17%、11.73%、11.22%、6.87%、6.70%；分离到多重耐药菌41株，检出多重耐药菌类别分别为产超广谱β内酰胺酶大肠埃希菌23株，产超广谱β内酰胺酶肺炎克雷伯菌8株，耐甲氧西林金黄色葡萄球菌（MRSA）6株，耐碳氢霉烯类肺炎克雷伯菌肺炎亚种1株；多重耐药铜绿假单胞菌2株，多重耐药鲍曼不动杆菌1株。结论病原菌以革兰阴性菌为主，耐药性日趋严重，应根据耐药分析结果合理选择抗菌药物。