简介：T房间激活是在仅仅通过这个过程后来开始适应有免疫力的反应的一个批评过程特定的T房间区分进调停的武装受动器T房间的na(i)ve抗原实际有免疫力的response.DuringT房间激活，na(i)veT房间经历同种细胞的扩大并且获得能力杀死感染病原体的目标房间或生产为调整有免疫力的反应必要的cytokines。T房间的不恰当的激活或inactivation导致autoimmunity或严重免疫不全。PKC-有选择地在T房间被表示并且为调停要求了T房间激活过程。在PKC-缺乏的老鼠在T房间激活，幸存和activation-inducedcell死亡展出缺点。PKC-有选择地translocates到免疫学的触处并且调停为为T房间activation.Furthermore是必要的NF-B，AP1和NFAT的激活要求的信号，PKC--/-鼠标在vivo在T调停房间的有免疫力的回答的开发显示了多重缺点。PKC-因此是在vivo在T调停房间的有免疫力的回答在多重阶段调整T房间功能的一个批评分子。细胞与分子的免疫学。2006；3(4):263-270。

简介：Hormonesandtheirreceptorsregulatecellgrowth,differentiationandapoptosisandalsoplayimportantrolesinimmunefunction.Recentstudiesonthesubfamilyoftheorphannuclearreceptorsknownasretinoid-acidrelatedorphanreceptors(ROR)haveshedimportantinsightsontherolesofthisgroupofnuclearproteinsinthedevelopmentandfunctionoftheimmunesystem.RORαregulatesinflammatorycytokineproductioninbothinnateandadaptiveimmunesystemwhileRORγregulatesthenormaldevelopmentofTlymphocyterepertoireandsecondarylymphoidorgans.Cellular&MolecularImmunology.2004;1(6):401-407.

简介：Thisstudywasundertakentohaveabetterunderstandfortheprocessandtheunderlyingmechanismstolimitmacrophageactivationandpopulationofactivatedmacrophages.AcomprehensivekineticsofcytokineproductionwasperformedinmurineperitonealmacrophagesrecoveredfromBalb/cmiceatvarioustimeduringthecourseofanintraperitonealinjectionwiththioglycollate(TG).TheexpressionofcellsurfacemoleculessuchasMHC-Ⅰ,MHC-Ⅱ,B7-1andB7-2ofthesemacrophageswerealsodeterminedbyflowcytometry.Thepresentfindingsofourresearchsuggestedthatthepopulationofactivatedmacrophagesandtheactivationofmacrophages(includingcytokinesproductionandexpressionofcellsurfacefunctionalmolecules)werestrictlycontrolledduringinflammationprocess.Thisisoneoftheimportantmechanismstoretainthehosthomeostasis.Cellular&MolecularImmunology.2004;1(1):57-62.

简介：TheannualmeetingoftheHeartFailureAssociationofESCinLisbon,inJune2005,wasexceptionallysuccessful.Thereweremanyveryinterestingpresentationsandworkshopswiththeuniquetitle:StatinsinheartfailureCholesterol-loweringisnottheonlygoalHeartfailure(HF)isaprogressivediseasewithcoronaryarterydisease(CAD)asthemostoftenunderlyingetiology.TreatmenttopreventprogressionofheartfailurehasbeentargetedtoreversetheconsequencesofHFandtoalessextentthecause-theatheroscleroticplaqueitself.Ontheaverage50%ofpatientswithheartfailurearetreatedwithlipidintervention.Lipid-loweringtreatmentwithstatinsclearlyreducesmorbidityandmortalityofpatientswithdocumentedCAD.SincetheprevalentetiologyofheartfailureisCAD,itspreventionmayreduceheartfailureprogression.However,recentstudiessuggestthatpleiotropiceffectsofstatinsaremoreimportantthantheinfluencerelatedtotheircholesterolloweringmechanism.Furthermoreitissuggestedthatlowlevelsofcirculatinglipoproteinsandcholesterolmaybeindependentpredictorsofimpairedoutcomeinpatientswithheartfailure.Therearesomepossibleexplanationsforthisfinding.Highlevelsofcholesterolcanbebeneficialtoheartfailurepatients;cholesterol-richserumlipoproteinsareabletomodulateinflammatoryimmunefunctionbecausetheybindanddetoxifybacteriallipopolysaccharide,averystrongstimulatorofthereleaseofproinflammatorycytokinesthatpromoteheartfailureprogressionanddeath.SocurrentrecommendationsstronglyemphasizethattheaimoftreatmentofHFisnottolowercholesterol.

简介：ToelucidatethestructuresofSLA-DR(swineleukocyteantigenDR)genesofthreeChinesepigstrains(Gz,BmandYn),theSLA-DRAandSLA-DRBcDNAwereamplifiedbyRT-PCRandsubjectedtodeterminethesequences.ThewholestructuresofSLA-DRAallelesareidenticalamongthreestrains,consistingof759nucleotidesincludinganopenreadingframe(ORF),andaresharedwiththosereportedfromNIHminipigsSLA-DRAcandSLA-DRAd.ThesamelengthoftheORF-containingSLA-DRBgenesofthreeChinesepigstrainswasalsoidentified.Theyarecomposedof801nucleotidesencodingaxenogeneicantigenmoleculeof266aminoacidresidues.ThenucleotidesequencesoftheSLA-DRBgenes,however,aredifferentwhencomparedeitheramongthethreestrainsorwiththepublisheddataofSLA-DRBsequences,whichallowedournovelSLA-DRBallelesreceivingtheiraccessionnumbersAY102479,AY102480andAY102481fromtheGenBank.ThisstudyfurtherrevealsthatthephylogenichomologiesofMHCDRorDR-likegenesinstructuresofnucleotidesanddeducedaminoacidsbetweenChinesepigs(SLA)andhuman(HLA-DRB1*0901)arebetterthanthosebetweenpigsandmice(H-2bEβ).HighsimilaritieswerealsofoundforDRα-DRβheterodimersbetweenChinesepigsandhumanintermsofaminoacidssequencescriticalforbindingwithhumanCD4coreceptormolecule,whicharebetterthanthosebetweenSLA-DRandH-2I-Emolecules.Afunctionaltestindicatedthat,bycotransfectionwithBm-DRAandBm-DRBgenes,theBm-DRmolecule-expressedL929cellscouldstimulatehumanTcellsquitewellinaxenogeneicreactioninpresenceofhumanAPCs.