简介：ObjectivesTodetectwhetherpersistingortransientglucosemetabolismdisorderisresponsibleforadmissionhyperglycemiainpatientswithacutemyocardicinfarction(AMI).MethodsTwogroupsofpatientswereenrolled:AMIgroupandcontrolgroup.Fastingplasmaglucose,2hoursplasmaglucose,glycatedalbumin(GA)andglycatedhaemoglobin(HbA1c)weremeasuredatbaselineinbothgroupsand30daysafterAMIattackinAMIgroup.Results(1)Therewerenosignificantdifferencesinbaselinecharacteristicsbetweenbothgroups;(2)Comparedwiththecontrolgroup,thelevelsofGAandHbAlcinAMIgroupatbaselineweresignificantlyhigher.(3)At30dayfollow-upinAMIgroup,bothFBGand2hPGdecreasedtonormalvalues,HbAlcdidnotchange,butonlyGAkeptonincreasing.ConclusionsHyperglycemiaonadmissioninpatientswithAMIresultedfrombothpreexistingmetabolicdisorderandstressreactionaswell.GAistheonlyindicatorthatcouldrecalltheexaggerationofglucosemetabolicdisorderduringAMIattackat30dayfollow-up.

简介：ObjectivesToinvestigatetheeffectoftelmisartanonhumanumbilicalveinendothelialcells(HUVEC)exposedtohighglucoseinvitroandtherelatedmechanism.MethodsHUVECswereincubatedwithtelmisartanandglucose(5mmol/L,30mmol/L)at0h,12h,24h,36h,48h,respectively.Thelevelofmalondialdehyde(MDA)andsuperoxidedismutase(SOD)inthesupernatantofculturedendothelialcellswasmeasuredbythiobarbituricacidtestandxanthineoxidasetest.TheexpressionofPPAR-γwasdeterminedat24hourwithWesternblottechnique.ResultsWhentheendothelialcellswereculturedinhighglucoseenvironment,theMDAlevelwassignificantlyincreased,buttheSODactivityandtheproteinexpressionofPPAR-γweremarkedlydecreased.However,thehighglucose-inducedeffectswereinhibitedbytelmisartanintervention.ConclusionTelmisartancandecreaseoxidativestressandincreasePPAR-γexpressionofendothelialcellsinhighglucoseenvironment.

简介：BackgroundInthisstudy,weaimedtoevaluatetheimpactofabnormalglucose,lipidandCystatin-ConthevirtualPvectorcharacteristics,whichhaven’tbeenreportedinpreviousstudies.Methods204ofnon-diabetesmellitus(NDM),130ofDM(type2)and39ofimpairedglucosetolerance(IGT)patientswereconsecutivelyandretrospectivelyrecruited.Weselectedaone-minutelengthofelectrocardiogramat4AMforanalysis.Afteraseriesofcalculatingalgorisms,weobtainedthevirtualplanarPvectorparameters.ResultsTherewerenosignificantdifferencesinFPV,FPA,RSPV,RSPA,HPVandHPAgroups.Afteradjustingconfoundingfactors,theregressioncoefficients(RC)wereestimatedasfollow:forFPV,femalegender(RC-0.21,P=0.02),triglyceride(RC-0.09,P<0.01),RVOT(RC0.03,P=0.02);forRSPV,femalegender(RC-0.21,P<0.01),triglyceride(RC-0.10,P<0.01),averageheartrate(RC0.01,P=0.02);forHPV,triglyceride(RC-0.08,P<0.001),LDL(RC-0.19,P<0.01),ApoB(RC0.67,P<0.01);forRSPA,Btypeofblood(RC-22.06,P=0.02),Cystatin-C(RC-72.79,P=0.02),thicknessofinterventricularseptum(RC3.70,P=0.01).Cystatin-CwassuggestedasacurerelatedtoRSPA,andthecut-offpointwas1.6mg/L.TherewerenosignificantriskfactorsassociatedwithFPAandHPA.TherewasnodifferenceinvirtualPvectoramongDM,IGTandNDMgroups.ConclusionIncreasedlevelsoflipidandCystatin-CsignificantlyimpactthecharacteristicsofvirtualPvector,whereasglucosedoesnot.Thesechangesmaycomefromahigherlowvoltageatrialareaandabnormalorientationofatrialdepolarization.

简介：Complicationsaremorefrequentinelderlypatientswithcoronaryheartdisease(CHD),suchasimpairedglucosetoleranceandconstipations.Itisalwaysdifficulttocurethesecomplicationsinclinicalpractice.Inthiscasewehadsuccessfullycuredaneighty-threeyearsoldmanwithCHDcomplicatingimpairedglucosetoleranceandconstipationbyintegratedChinese-Westernmedicine.

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简介：BackgroundItiswellknownthattherewasasignificantlinkbetweenpreproceduralbloodglucoselevelsandshort-termandlong-termadverseoutcomesinpatientsundergoingelectivePCI.However,theroleofpre-proceduralbloodglucoselevelsasapredictorofadverseeventsinCKDpatientswhounderwentPCIoutofestablisheddiabeteshasyettobeidentified.MethodsInourstudy,weconductedaprospectivestudyof331acutecoronarysyndrome(ACS)patientswithCKDwhounderwentPCIoutofestablisheddiabetes.Patientsweredividedintotwogroupsbasedonpre-proceduralglucoselevels(hypoglycemia<7.0mmol/L;hyperglycemia≥7.0mmol/L).Allpatientswerefollowedupprospectivelyformajoradversecardiovascularevents(MACEs)andmortalityfor6months.ResultsInourcohort,hyperglycemiapatientsreportedahigherincidenceofin-hospitalmortalitythanhypoglycemiapatients(7.5%vs.0%,P<0.001).Hyperglycemiapatientsreportedasignificantlyhigherrateof6-monthMACEs(10%vs.2.4%,P=0.007),allcausemortality(7.5%vs.1.6%,P=0.015),andcardiovascularmortality(6.2%vs1.6%,P=0.041)comparedwithhypoglycemiapatientswithpre-proceduralglucoselevels<7.0mmol/L.Multivariateanalysisdisclosedthatapre-proceduralglucoselevel≥7.0mmol/LwasasignificantindependentpredictorofMACEs(OR=2.53,95%CI1.68-17.15,P=0.004),allcausemortality(OR=4.6,95%CI1.10-18.84,P=0.036),andcardiovascularmortality(OR=6.2,95%CI1.53-24.94,P=0.011)at6monthsinpatientsafterPCI.ConclusionThestudysuggestedthatpre-proceduralglucoselevelsareassociatedwithshort-termcardiovascularoutcomeCKDpatientswhounderwentPCIwithoutestablisheddiabetesinthesettingofACS.