简介:目的探讨冠心病(CHD)合并2型糖尿病(T2DM)患者经皮冠状动脉介入治疗(PCI)术前给予左卡尼汀(L-CN)对心肌损伤的保护作用。方法拟诊CHD合并T2DM并计划行冠状动脉造影的60例患者,随机分为两组,治疗组术前在标准治疗的基础上给予静脉滴注L-CN,对照组仅给予标准基础治疗。造影结果不适合行PCI治疗的病人被剔除,最终治疗组入选26例,对照组入选20例。所有患者术前及术后第24小时、1周测定心肌钙蛋白I(cTnI)和高敏CRP(hs-CRP)。结果总共46例患者PCI术后24小时和1周cTnI和hs-CRP均明显上升(P〈0.01);但治疗组患者在术后24小时及术后1周血浆cTnI和hs-CRP水平均较对照组为低(P〈0.05,P〈0.01);直线相关分析显示,PCI术后24小时两组cTnI和hs-CRP水平显著正相关(r=0.75,P〈0.01)。结论合并2型糖尿病的冠心病患者PCI治疗术后炎症反应和心肌损伤较为明显,PCI术前给予左卡尼汀可显著降低手术所致的心肌损伤,PCI引起的心肌坏死很可能与其触发的炎症反应有直接关系。
简介:BackgroundDuringprimarypercutaneouscoronaryintervention(PCI),manualthrombectomymayreducedistalembolizationandthusimprovemicrovascularperfusion.Smalltrialshavesuggestedthatthrombectomyimprovessurrogateandclinicaloutcomes,butalargertrialhasreportedconflictingresults.MethodsWerandomlyassigned10,732patientswithST-segmentelevationmyocardialinfarction(STEMI)undergoingprimaryPCItoastrategyofroutineupfrontmanualthrombectomyversusPCIalone.Theprimaryoutcomewasacompositeofdeathfromcardiovascularcauses,recurrentmyocardialinfarction,cardiogenicshock,orNewYorkHeartAssociation(NYHA)classIVheartfailurewithin180days.Thekeysafetyoutcomewasstrokewithin30days.ResultsTheprimaryoutcomeoccurredin347of5033patients(6.9%)inthethrombectomygroupversus351of5030patients(7.0%)inthePCI-alonegroup(hazardratiointhethrombectomygroup,0.99;95%confidenceinterval[CI],0.85to1.15;P=0.86).Theratesofcardiovasculardeath(3.1%withthrombectomyvs.3.5%withPCIalone;hazardratio,0.90;95%CI,0.73to1.12;P=0.34)andtheprimaryoutcomeplusstentthrombosisortarget-vesselrevascularization(9.9%vs.9.8%;hazardratio,1.00;95%CI,0.89to1.14;P=0.95)werealsosimilar.Strokewithin30daysoccurredin33patients(0.7%)inthethrombectomygroupversus16patients(0.3%)inthePCI-alonegroup(hazardratio,2.06;95%CI,1.13to3.75;P=0.02).ConclusionsInpatientswithSTEMIwhowereundergoingprimaryPCI,routinemanualthrombectomy,ascomparedwithPCIalone,didnotreducetheriskofcardiovasculardeath,recurrentmyocardialinfarction,cardiogenicshock,orNYHAclassIVheartfailurewithin180daysbutwasassociatedwithanincreasedrateofstrokewithin30days.
简介:backgroundIn-hospital(IH)mortalityforpatientsunderwentpercutaneouscoronaryintervention(PCI)inourcenterfrom1994to2004was1.01%(33/3252).ThePCIvolumeinourstateincreasedquicklyduringthelastfewyears,sodiditinourcenter.MethodsandResultsWeretrospectivelyscreenedatotalof3274caseswhounderwentPCIin2009,amongwhich24(0.73%,P=0.22vs.1994-2004)IHdeathoccurred.Analysisofthese24casesrevealedthatallofthemwerediagnosedasacutecoronarysyndrome(ACS),andhadtheindicationofPCI.Fifteen(63%)carriedachanceof≥10%todieinhospitalaccordingtoGRACEmodel.Significantleft-main(LM)and/ortriple-vesseldisease(TVD)weredefinedin21(88%)cases.SYNTAXscoreswere≥23in15(63%)and≥33in12(50%)cases.CompleterevascularizationwithPCIwasfulfilledinonly5(21%)cases.Myocardialischemiaorheartfunctioncouldn'timprovebyPCIwasthemostfrequentcauseofdeath,whichcontributedtothatof11(46%)cases.Cardiacruptureoccurredinallofthe4patientswithSTelevatedacutemyocardialinfarction(STE-AMI)involvinginferiorventricularwallbut'reserved'anteriorwall,andcontributedmainlytotheirmortality.ConclusionsPost-PCIIHmortalityhasmaintainedlowinourcenter.ItmostlikelyoccursinpatientswithACS.Themajorcauseofdeathisthatmyocardialischemiacouldn'timprovebyPCI,exceptforpatientswithinferiorbutnoanteriormyocardialinfarction,whosufferfromcardiacruptureinstead.
简介:BackgroundIt'saneffectivetreatmenttoachievepercutaneouscoronaryinterventioninAMIpatients,whichrapidlyimprovesthebloodsupplyofcoronaryartery.StudieshaveshownthatdifferentmodesofPCItherapyhavedifferenteffectsinAMIpatients.TheaimofthisstudywastoexploretheeffectsandclinicalsignificancesofemergencyorlatePCItherapyonleftventricularremodelingandcardiacautonomicfunctioninacutemyocardialinfarction(AMI)patients.MethodsOnehundredandfiftycasesofAMIpatientswererandomlydividedintothreegroups,whichallweregiventheroutinemedicine.ThetwotherapygroupsweretheemergencyPCIgroup(n=60)andthelatePCIgroup(n=50).Thevariationsofheartrateturbulence(HRT)andheartratevariability(HRV)parameterswereobservedafter2weeksoftreatmentby24-hourambulatoryECG.ResultsComparedwiththecontrolgroup,after2weeksoftreatment,thelevelsofTS,SDNNandSDANNoftwoPCI-treatedgroupwassignificantlyhigher(P<0.01),TOwerelower(P<0.01)thanwhichinthecontrolgroup.ThereweresignificantdifferencesinTS,SDNN,SDANNandTObetweenthetwoPCItreatmentgroup(P<0.05).ConclusionEmergencyPCIorlatePCImaygivecoronaryeffectivereperfusion,improveleftventricularfunctionandautonomicnervousfunction,andpreventmalignantarrhythmiastooccur.ThetreatmentofprimaryPCIissuperiortodelayedPCI.
简介:目的探讨经桡动脉经皮冠状动脉介入治疗(PCI)术后并发症的循证护理。方法随机在新疆医科大学第一附属医院选择206例患心肌梗死或需行PCI的患者,手术后采取不同的护理方法,分别为循证护理组(n=105)和常规护理组(n=101),对比指标有患者满意度、SF-36生存质量评分及术后并发症,包括出血、局部血肿、上肢静脉栓塞、心律失常等。结果循证护理组患者男性58例,女性47例,年龄35~69岁,平均(50.7±6.1)岁,常规护理组患者中有男性56例,女性45例,年龄34~68岁,平均(50.2±6.3)岁,两组患者在年龄、性别构成、心梗类型、梗死部位、合并疾病及服用药物方面比较差异无统计学意义(P均>0.05)。循证护理组患者的并发症发生率更低、满意度更高,分别为5.71%和97.14%,与常规护理组相比差异明显(P<0.05);常规护理组患者的生存质量评分明显低于循证护理组,差异有统计学意义(P<0.05)。结论经桡动脉PCI术后给予循证护理,可有效降低术后并发症,提高满意度。
简介:目的:探讨ST段抬高型心肌梗死(STEMI)患者不同时间行经皮冠状动脉介入治疗(PCI)的安全性和有效性。方法:138例STEMI患者被随机分为直接PCI组(69例,确诊后立即进行PCI治疗)和择期PCI组(69例,给予急性溶栓治疗后择期进行介入治疗)。比较两组患者左室射血分数(LVEF)、肌酸磷酸激酶(CPK)峰值、CPK高峰时间、肌酸激酶同工酶(CK-MB)峰值、CK-MB高峰时间、住院期间心脏破裂率、梗死复发率、30d和1年内死亡率。结果:治疗后与择期PCI组比较,直接PCI组LVEF[(49.3±6.8)%比(58.2±7.7)%]、CPK峰值[(74.9±49.3)IU/L比(113.0±59.3)]IU/L、CK-MB峰值[(1983.1±1251.2)IU/L比(2588.6±1592.3)IU/L]均显著升高,CPK高峰时间[(19.4±6.5)h比(13.9±4.5)h]、CK-MB高峰时间[(19.7±7.7)h比(12.7±7.2)h]显著缩短,P均<0.01;直接PCI组住院期间心脏破裂率(5.8%比0)、梗死复发率(17.5%比6.3%)、30d(11.0%比2.2%)和1年内死亡率(22.2%比8.2%)均显著降低(P均<0.05)。结论:在ST段抬高型心肌梗死患者直接介入治疗的临床效果更优且安全性更佳,有临床推广价值。
简介:目的分析冠状动脉粥样硬化性心脏病(冠心病)患者经冠状动脉介入治疗(PCI)前后代谢产物的变化.方法纳入2013年1月~11月于北京安贞医院诊治的冠心病患者400例,其中男性208例,女性192例,年龄(61.1±10.1)岁.所有患者均行PCI,术前及术后1个月抽血,采用液相色谱串联质谱和分析软件分析代谢产物的变化.结果与PCI前比较,PCI后冠心病患者瓜氨酸、皮质酮、钴胺素、D-核糖-5-磷酸、苹果酸、血清素、羟基胆固醇、磷脂、心磷脂、胆固醇、前列腺素F、3-羟基戊基肉碱、1,25-二羟基D改变明显,差异有统计学意义(P均〈0.05).与PCI前比较,PCI后冠心病患者类固醇激素、类固醇、甘油磷脂、亚油酸明显变化,差异有统计学意义(P均〈0.05).结论冠心病患者PCI前后机体代谢发生改变,代谢产物和相应的代谢通路明显变化,为介入术后治疗提供新思路.
简介:Formanyyears,cardiovascularclinicianshavebeenmakingtheargumentthatcompleterevascularizationisthewaytoproceedinpatientswithanyformofischemicheartdisease.Ibelievethatcardiovascularsurgeonsagreewiththisapproachandtrytheirbesttocompletelyrevascularizepatientsatthetimeofcoronaryarterybypassgraftsurgery.AttheUniversityofFlorida,we,likemanyothersintheworld,treatanacutemyocardialinfarctionasanemergency,and,ifthereisSTsegmentelevation,thepatientistransportedimmediatelytothecardiaccatheterizationlaboratoryfromtheemergencydepartment,forrecanalizationoftheculpritartery.
简介:backgroundToinvestigatetheeffectofintra-aorticballoonpumping(IABP)onno-reflowphenomenoninprimarypercutaneouscoronaryintervention(PCI)forST-ElevationMyocardialInfarction(STEMI).MethodsClinicaldataof22acutemyocardialinfarctionpatientsafterPCIwithangiographicno-reflowphenomenonwereretrospectivelyanalyzedbetweenJanuary2006andDecember2009.12patientsunderwentIABP,other10patientsascontrolgroup.Weobserveddifferenceofcardiacstructure,brainnatriureticpeptide(BNP)andventricularsystolicfunctionbetweentwogroup,aswellascardiacinjurymarkers(MYO,CK-MB,cTnI)inbothgroupsonthedaysof1,2,3,5,7,10afterthedifferentinterventions.Inaddition,cardiacstructureandventricularsystolicfunctionincludingleftatriummedialdiameter(LAMD),leftventricularmedialdiameter(LVMD),leftventricularejectionfraction(LVEF)wasevaluatedafter10days,3months,6months.Finally,statisticswasusedtoanalysisthedata.ResultsTheseveralvasoactivesubstancesaswellascardiacinjurymarkersandLAMD,LVMD,LVEFof10days,3months,6monthsofIABPgroupweresignificantdifferencewithcontrolgroup(P<0.05).BNPtargetsofIABPgroupcomparedwiththecontrolgroupnosignificantdifference(P>0.05).ConclusionsIABPhaseffectsonprognosisinSTEMIpatientswhoperformedPCIwithangiographicno-reflowphenomenon,whichisconducivetorecoveryofheartfunction.
简介:ObjectiveToevaluatereliabilityandsafetyofAngio-sealhemostasisdeviceappliedtothefemoralarterialpuncturesiteafterpercutaneouscoronaryintervention(PCI).MethodsIn40patientsafterPCIinourinstituteduringtheperiodbetweenMay2002andDecember2003,Angio-sealdevicewereusedtosealthefemoralarterialpuncturesite.ResultsAlltheAngiosealdevicesweresuccessfullydeployedin40patients(successfulrate;100%);themeantimetohemostasiswas45±12sec;themeantimetoambulateafterangiosealclosurewas1.9?.5hours.Nomajorgroinandsystemiccomplicationwasobserved.Therewasminorgroinoozingin2casesandsmallhemotomain1patient.ConclusionsAngio-sealclosuredeviceofthefemoralarterypuncturesiteafterapercutaneouscoronaryprocedureissafe.Itcanshortenthetimetohemostasis,leadstoearlymobilization,andreducegroincomplication.Thedisadvantageisrelativelyexpensive.
简介:目的探讨急诊经皮冠脉介入术(PCI)治疗急性ST段抬高性心肌梗死(STEMI)患者术后ST段回落的临床意义。方法入选2011年1月~2013年9月辽宁省人民医院心血管内科急诊PCI治疗的150例STEMI患者进行回顾性分析,根据术后1h内患者心电图检查ST段回落百分比是否>50%分为A组84例(ST段回落百分比>50%)和B组66例(ST段回落百分比≤50%),比较两组患者术前、术后24h的心肌酶谱指标、术后2周心功能指标及术后1年内心血管不良事件的发生率。结果术前及术后24hA组的肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白(cTnT)测定值均显著的低于对应时间点的B组患者(P<0.05);术前,A、B两组患者的左室射血分数(LVEF)值差异不具有统计学意义(P>0.05),术后24h,A组患者LVEF值显著高于B组患者(P<0.05);术前及术后24hA组的左室舒张末期容积(LVEDV)测定值均显著的低于B组患者(P<0.05);术后1年A组患者的心血管不良事件累积发生率9.52%显著的低于B组患者的31.82%(P<0.05)。结论急诊PCI术后ST段迅速回落(ST段回落百分比>50%)的STEMI患者心功能及心肌酶谱指标恢复更好,远期不良心血管事件发生率更低。
简介:目的:探讨加强随访对冠状动脉粥样硬化性心脏病(冠心病)患者PCI术后依从性及1年预后的作用。方法选取2011年6月-2012年6月在中国人民警察部队总医院心内科诊断为冠心病并择期行PCI介入治疗的患者126例,其中男性62例,女性64例。分为常规随访组和加强随访组,每组各63例,分别进行常规随访和加强随访。随访1年,比较两组患者在随访依从性、冠脉造影复查依从性、冠心病二级预防依从性及1年预后的差异。结果与常规随访组比较,加强随访组随访依从性(年随访人次)、冠脉造影复查依从性(19%vs.61.9%)及二级预防服药依从性(68.3%vs.95.2%)增加,差异具有显著统计学意义(P均<0.01)。加强随访组再发心绞痛比例明显低于常规随访组(9.5%vs.26.9%,P<0.05)。常规随访组再次血运重建3例,心肌梗死2例;加强随访组再次血运重建1例,心肌梗死1例,两组MACE发生率差异无统计学意义(P>0.05)结论加强随访制度提高了冠心病患者PCI术后依从性,改善1年预后。
简介:目的:探讨冠状动脉慢性完全闭塞(CTO)病变患者经皮冠状动脉介入(PCI)治疗效果及其相关影响因素。方法:选择2009年12月~2014年1月我院行冠脉造影确诊为CTO病变患者96例,分为PCI组(75例)和常规治疗组(21例)。观察PCI治疗效果,治疗前后两组肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)、N末端B型利钠肽前体(NT-proBNP)水平的变化及超声心动图变化,并分析其影响因素。结果:本组75例CTO患者经PCI治疗后成功开通64例(85.3%)。治疗后1周后两组CK-MB、cTnT和NT-proBNP水平均较治疗前显著降低(P<0.05或P<0.01),与常规治疗组比较,PCI组治疗后CK-MB[(16.28±4.12)U/L比(14.26±7.12)U/L]、cTnT[(0.32±0.14)ng/ml比(0.22±0.12)ng/ml]和NT-proBNP[(1029.27±332.86)pg/ml比(879.73±332.86)pg/ml]水平降低更显著(P<0.05或P<0.01)。治疗后3个月后超声心电图显示,与常规治疗组比较,PCI组左室舒张末期容积指数[LVEDVI,(79.4±20.1)ml/m2比(68.2±22.4)ml/m2]、左室收缩末期容积指数[LVESVI,(49.1±17.2)ml/m2比(39.2±16.3)ml/m2]显著降低,左室射血分数[LVEF,(44.2±8.0)%比(46.8±8.2)%]显著升高(P均<0.05);多元逐步Logistic回归分析显示:胸痛时间>3年、心肌梗死病史、合并三支病变、靶血管开口闭塞是影响CTO疗效的独立危险因素(OR=0.442~0.992,P均<0.01)。结论:PCI治疗可以改善CTO患者冠脉血流灌注、心功能和心室重构,而胸痛时间、心肌梗死病史、合并三支病变、靶血管开口闭塞是影响CTO疗效的独立危险因素,应予以重视。
简介:BackgroundThecoronarycollateralcirculationhasapositiveeffectontheischemicmyocardium.Butitislimitedforpatientsmissingthetimewindowoftotalocclusionofthecoronaryarteryelectivepercutaneouscoronaryintervention(PCI).Theeffectofcollateralcirculationonleftcardiacfunctionhasbeenlessstudied.MethodsAtotalof34patientswithoneormorecoronaryarteryocclusionwhounderwentcoronaryangiographyandRentrop'smethodweredividedinto2groups:Goodcollateralcirculation(Agroups,Rentropscore2-3,n=19)and(Bgroups,Rentropscore1-2,n=15).Theimprovementofleftventricularenddiastolicvolume(LVEDV)andleftventricularejectionfraction(LVEF)werecomparedbetweenthetwogroupsbeforeandafterPCI.ResultsIngoodcollateralcirculationgroup,leftventricularejectionfraction(LVEF)wassignificantlyhigherafterPCI(P<0.05).Inpoorcollateralcirculationgroup,leftventricularenddiastolicvolumeindex(LVEDV)wassignificantlyincreasedafterPCI(P<0.05).ConclusionsGoodcollateralcirculationhasasignificantprotectiveeffectonleftventricularfunction.PCIoperationcansignificantlyimprovetheprognosisofpatientswithgoodcollateralcirculationofcoronaryarteryocclusion.