简介：Althoughmanytraditionaltherapiesareavailableforgenitalwarts(GW)，oneofthemajorproblemsinthetreatmentofGWisahighrecurrenencerate．Inordertoresolvetheproblemofrecurrence，newtheraputicapproacheshavebeeninvestigated．Newapproachesbeingexploredinclude5-fluorouracil／epinephrineinjectablecollagengel,5％imiguimodcreamandhumanpapillomavirusvaccine．Fluorouracil／epinephrineinjectablecollagengelachieveshighconcentrationoffluorouracilatthesiteofinjection．Imiguimodisanovelimmune-responesmodifier,givinggoodclearanceratesandtolerablesideeffects．AlthoughtheuseofanHPVvaccineisfaraway，preliminarystudiesshowthatitmaybepossibletodevelopsuitableprophylacticandtherapeuticvaccinestogenitalwarts．

简介：Objective:Toinvestigatetheefficacyofcombina-tionofcircumcisionandmicrowaveongenitalwartsinuncircumcisedmen.Methods:Arandomized,prospectivestudyof109uncircumcisedadultmenwithgenitalwartswascon-ductedinaSTDclinicinZhanjiang,Guangdong.Onegroup(n=54)receivedmicrowavetherapyonly,whiletheothergroup(n=55)wastakenthecombinationofcircumcisionandmicrowavetherapy.Therecurrenceswereobservedattheendofmonths3,6and12,andoperativecomplicationswerealsorecorded.Results:Therewerenosignificantdifferencesinthemeanageanddurationofthediseasebetweentwogroups(P>0.05).Noseriousoperativecomplicationsweredocumented.Therecurrencerateincircumci-sionplusmicrowavegroupwasmarkedlylowerthanthatinmicrowavegroup(12.7%vs29.6%,P<0.05),whilethedifferencesinearlyandlaterecurrencesbetweentwogroupsshowednostatisticalsignificance(P>O.05).Conclusion:Circumcisioncanbesafelyperformedunderlocalanesthesiainanoutpatientsetting.Com-binationofcircumcisionandmicrowavecanproduceexcellenteffectaswellaslesstissuedamage,therefore,itmaybeidealforuncircumcisedpatientswithextensivecondvlomas.

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简介：Objective:ToexploretherelationshipbetweenquantitativeTreponemapallidumDNA(TP-DNA)PCRtestingandtheToludineRedUnheatedSerumTest(TRUST)inpatientswithsyphilisbeforeandaftertreatment,andevaluatetheclinicalvalueofquantitativeTP-DNAtestinginthediagnosisandtreatmentevaluationofsyphilis.Methods:29patientswithprimary(12cases)orsecondary(17cases)syphilis,whometthecriteriasetforthisstudywererecruitedassubjects.Allpatientsweretreatedwith2.4millionunitsbenzathinepenicillinIMweeklyfor3weeks.QuantitativetestsofTP-DNAinthepatients'plasmawereperformedusingFQ-PCRbeforeandafterthetreatment.SerologictestsincludingTRUSTandTPPAwerealsoperformed.Results:Beforethetreatment,9outof12primarysyphilispatients(75%)andallsecondarysyphilispatients(17/17)testedpositiveforTreponemapallidum(TP)byTP-DNAtesting.TheaveragequantitativetestvaluesofTP-DNAinprimaryandsecondarysyphilispatientswere(3.38±2.34)×10^4and(5.73±1.33)×10^6copies/ml,respectively.Afterthreemonthsoftreatment,1ofthe9primaryand5outof17secondarysyphilispatientswerepositiveuponTP-DNAtesting,respectively.TheaveragequantitiesofTP-DNAwere2.01×10^2copies/mlinprimaryand5.87×10^2copies/mlinsecondarysyphilispatientswithpositiveTRUSTandTP-DNAtests,and3.09×10^2copies/mlforthosewithnegativeTRUST,respectively.Afterninemonthsoftreatment,alltheprimaryandsecondarysyphilispatientswerenegativeuponTP-DNAtesting,whileallprimaryand14of17(82.35%)secondarysyphilispatientsshowednegativeTRUSTresults.Conclusion:ThattheresultsofTP-DNAtestsarenotconsistentwiththoseofTRUSTbeforeandaftertreatmentindicatesthatquantitativeTP-DNAtestingmayhavevaluableclinicalsignificanceintheearlydiagnosisandevaluationoftreatmentregimensforsyphilis.

简介：Objective:ToevaluatethetherapeuticeffectofNd:YAGlaserunderurethroscopeforthetreatmentofintraurethralCandylomaAcuminata(CA)inmales.Method:Nd:YAGlaserunderurethroscopewasemployedtoremovethewarts.Result:SeventeenpatientsoutofeighteencaseswithCAwerecuredafterthefirstprocedure.Thecureratewas94.4%.Forsecondtreatment,thecureratewas100%andnorelapseoccurredafterobservationfor12-24months.Conclusion:Nd:YAGlaserbyurethroscopeisaverygoodmethodforthetreatmentofintraurethralCA.