简介：摘要目的探讨老年股骨颈骨折(FNF)围术期的护理方法。方法对2013年4月～2014年2月我院收治的26例FNF患者进行回顾分析和总结。结果26例FNF患者手术均全部成功，术后无一例出现下肢深静脉血栓，无一例出现肺部感染。患者均顺利全部出院，平均住院(20．6+5．4)d，随访6个月～2年，骨折治愈，康复良好。结论正确有效的术前指导、精心的术后护理、科学合理地进行功能锻炼，可有效地减少老年股骨颈骨折并发症的发生，促进早期康

简介：摘要目的比较动力髋（DHS）、股骨螺旋刀片抗螺旋髓内针（PFNA）2种手术治疗外伤后老年粗隆间骨折的效果。方法针对2013年1月-2015年2月共40例粗隆间骨折患者，分为2组，20例PFNA治疗（PFNA组），20例DHS治疗（DHS组）。最后通过比较2组手术中创伤大小及出血量、术后髋关节活动恢复情况。结果PFNA组手术造成的创伤极小，出血量仅为80-150ml，统计分析平均值为115±25ml；DHS组手术造成的创伤极大，出血量为220-450ml，统计分析平均值为330±56ml，统计学比较p＜0.05。术后行Harris评分比较p＜0.05，有统计学意义。结论针对老年粗隆间骨折采用PFNA治疗具有术中出血少，术后能获得更好的髋关节功能。

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简介：目的观察Nucleus24CA型人工耳蜗植入后电极阻抗、行为反应阈值（T-level,T级）及最大舒适级（C-level,C级）的变化规律,分析其内在联系,探讨其对术后调机的指导意义。方法对81例植入Nucleus24CA型人工耳蜗患儿,分别在术中、术后1、2、6个月进行电极阻抗阈值测试,收集术后对应T、C值,并对其变化规律及相关性进行统计学分析。结果电极阻抗值术中检测最低,术后1月开机最高,此后逐渐减低（P〈0.01）;自蜗顶至蜗底各通道间电极阻抗值无显著差异（P〉0.05）。各电极通道T值、C值随术后时间延长逐渐增高（P〈0.05）,并与电极阻抗值呈线性相关。结论测定电极阻抗值是评估人工耳蜗刺激电极状态的有效手段;术后2月应同时调试T值及C值,此后则应对C值进行重点调试。

简介：Objective:Toinvestigateimmune-relatedgeneticbackgroundinbilateralsuddensensorineuralhearingloss(SSNHL).Casereportandmethods:Thecaseisa45-year-oldmanpresentingwitha7-yearhistoryofbilateralprofoundSSNHL.Bloodbiochemicaltestingdemonstratedincreasedlevelsoftotalcholesterol(5.88mmol/L).TestsforhepatitisBshowedapositiveantibodyagainstthehepatitisBcoreantigen.ComplementC3wasbelowthenormalvalue,andcomplementC4andIgGwereinthelowerrangeofnormalvalues.CTimagesshowedanormalinnerearandvestibularaqueductbutroundwindowmembranousossificationonbothsides.Atotalnumberof232immuneassociatedgenesweresequencedusingthenextgenerationsequencingtechnique.Results:Mutationsweredetectedin5genes,includingthephosphoinositide3-kinasecatalyticsubunitdelta(PIK3CD),caspaserecruitmentdomain-containingprotein9(CARD9),complementfactorH-related(CFHR2),immunoglobulinlambda-likepolypeptide1Protein(IGLL1),andtransmembranechannel-likegenefamily8(TMC8).InthePIK3CDgene,aC896Tsubstituteinexon7wasdetected.Thismutationcausesprimaryimmunodeficiencyandisanautosomaldominantdisease.Conclusion:ThePIK3CDC896TmutationresponsibleforprimaryimmunodeficiencymaycontributetotheonsetofbilateralSSNHLwithsubsequentrapidprogression.

简介：摘要目的探讨通过超声技术3%的罗哌卡因在锁骨骨折臂丛-颈浅丛麻醉中的临床应用价值。方法选择120例择期行锁骨骨折手术患者,年龄18-70岁,ASAⅠ-Ⅲ级，随机分为传统药物组（n=60例）和超声药物组（n=60例）。传统药物组通过手法盲探定位臂丛肌间沟及颈浅丛应用0.5%的罗哌卡因25ml完成阻滞，超声药物组通过B超实时引导定位臂丛肌间沟及颈浅丛应用0.3%的罗派卡因完成阻滞。结果超声药物组穿刺时间明显短于传统药物组（P<0.05)穿刺次数少于传统药物组（P<0.05);超声药物组穿刺后并发症明显低于传统药物组（P<0.01)；超声药物组麻醉效果优于传统药物组，药物浓度低于传统药物组。结论

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简介：Aratmodelofchronictympanicmembraneperforationwasdevelopedtobeusedinthesearchofnewmaterialsforthesealingoftheseperforations.AlongitudinalstudywascarriedoutinratssubjectedtoincisionalmyringotomyfollowedbytheapplicationofmitomycinCaloneorwithdexamethasone.Ratswerecheckedatdays3,7,10,14andweeklythereafteruntilperforationclosure,forupto6months.Theadditionofdexamethasoneisakeycomponentinordertoobtainachronicopening.Myringotomiestreatedwithsalinehadameanhealingtimeof8.5days.At8weeks,between62.5%and77.7%oftympanicmembranestreatedwithmitomycinCanddexamethasoneremainedperforatedandat6monthsthisnumberfellto21.4%.Thistechniqueisabletomaintainmosttympanicmembraneperforationspatentforatleast8weeks.Thisratmodelisadequateforitsuseinpreclinicalortranslationalresearch.

简介：Objective:EvaluatingtheauditoryfunctioninpatientswithchronichepatitisCtreatedwithsofosbuvirandribavirin.Methods:Thisstudyinvolved80patientswithchronichepatitisCwhoagreedtoreceivesofosbuvirandribavirin.Allparticipantsweresubjectedtobaselineotologicalandaudiologicalassessmentjustbeforetreatment.Theaudiologicalassessmentincludedstandardpuretoneaudiometry,extendedhighfrequencyaudiometry,immitancemetryandotoacousticemissions(OAEs)(transientanddistortionproduct).Accordingtobaselinehearingthresholdmeasurements,thestudypopulationwasdividedinto2groups.Group1included42patientswithnormalhearingsensitivity(250e8000Hz),andGroup2included38patientswithsensorineuralhearingloss.After24weeksoftherapy,otologicalandaudiologicalassessmentswererepeatedandcomparedbetweenthetwogroupsandbeforeandaftertherapy.Results:Post-treatmenthearingthresholdevaluationshowednosignificantdifferencefrompretreatmentevaluationatalltestedfrequencies.Therewasnostatisticallysignificantdifferencebetweenpreandpost-treatmentotoacousticemissionsresults.Conclusion:TherapywithsofosbuvirandribavirininchronichepatitisChasnonoticeableeffectsoncochlearfunctions.

简介：摘要目的整理我院骨折患者的临床护理资料，探讨优质护理服务队骨折病人骨折愈合以及功能恢复的影响。方法选取我院2014年1月至2015年6月收治的210例骨折患者，将其随机分为实验组和对比组，每组各105例患者，对比组患者通过传统护理方式进行护理，而实验组患者在对比组患者的基础上，通过优质护理服务模式进行护理，比较两组患者骨折愈合效果以及功能恢复效果。结果实验组骨折愈合总有效率为94.28%。对比组骨折愈合总有效率为88.57%，两组患者的骨折愈合总有效率差异明显具有统计学意义（P＜0.05）。结论通过对患者进行优质护理服务模式的护理，能够有效提升患者的骨折愈合能力以及功能恢复能力，具有非常高的临床参考价值。

简介：耳带状疱疹又称Hunt综合征,是由水痘-带状疱疹病毒感染引起的多发颅神经炎症,典型表现为头痛、耳痛、耳部疱疹、面瘫、耳鸣、耳聋及眩晕等,有的出现咽喉疱疹.本病临床表现复杂,易被漏诊、误诊,重者预后较差.现结合文献复习,对本病临床表现、实验室检查、诊断、鉴别诊断、治疗及预后进行讨论.

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简介：腺样囊性癌是一种来自于涎腺组织的少见肿瘤,发生于外耳道较少见,占整个外耳道恶性肿瘤的5%[1],因其发展缓慢,不易早期被发现,通常导致诊断延误或被误诊。本文通过3例病例,分析探讨其误诊原因,提高诊疗精准度。

简介：自发性扁桃体出血目前病因不明,临床少见,工作中常因症状不典型而延误诊治。本文报道三例考虑急性扁桃体炎引起的自发性扁桃体出血,根据病情急缓,保守治疗无效时可考虑手术,并予止血、抗感染等对症治疗。

简介：耳聋是常见的先天性疾病，世界范围内先天性聋的发生率为1／1000，其中遗传性聋占一半以上。

简介：ObjectiveToinvestigatetheearlychangeofcochlearribbonsynapsesoninnerhaircellsinresponsetoaminoglycosideototoxicity.MethodsC57BL/6Jmicereceivedintraperitonealinjectionofgentamicin(100mg/kg/day),andtheapicalcoilorganofCortiwasexaminedonthe4th,7thand10thday(n=10).Litter-mateswithoutgentamicintreatmentservedascontrols(n=10).RIBEYEonthepresynapticmembraneandAMPAreceptorsonthepostsynapticmembranewerelabeledwithCtBP2orGluR2/3respectively.Threedi-mensionreconstructionwasconductedusingthe3DSMAX8.0software.ResultsTherewerenodisruptionsofouterorinnerhaircellsinallgroups.However,thenumberofribbonsynapsesoncochlearinnerhaircellsincreasedsignificantlywithin7daysaftergentamicinexposure(P<0.01),followedbyasignificantde-creaseafter7days.ConclusionDuringtheearlystageofaminoglycosideototoxicity,increasedpopulationofcochlearribbonsynapsesmayindicateasignificantdown-regulationofsynapticfunction.

简介：ObjectiveTostudycharacteristicsofhearinglossafterexposuretomoderatenoiseexposureinC57BL/6Jmice.MethodsMaleC57BL/6Jmicewithnormalhearingatageof5-6weekswerechosenforthisstudy.Themicewererandomlyselectedtobestudiedimmediatelyafterexposure(GroupP0),or1day(GroupP1),3days(GroupP3),7days(GroupP7)or14days(P14)afterexposure.Theirbeforeexposureconditionservedasthenormalcontrol.Allmicewereexposedtoabroad-bandwhitenoiseat100dBSPLfor2hours,ABRthresholdswereusedtoestimatehearingstatusateachtimepoint.ResultsABRthresholdelevationwasseenateverytestedfrequencyatP0(P<0.01).Elevationathigh-frequencies(16kHzand32kHz)wasgreaterthanatlowerfrequencies(4kHzand8kHz,P<0.05).FromP1toP14,ABRthresholdscontinuouslyimproved,andtherewasnosignificantdifferencebetweenP14andbeforeexposure(P>0.05).ConclusionThereisafrequencyspecificresponseto100dBSPLbroad-bandwhitenoiseinC57BL/6Jmice,withthehigh-frequencybeingmoresusceptible.HearinglossinducedbymoderatenoiseexposureappearsreversibleinC57BL/6Jmice.

简介：ObjectiveToestablishalymphocytelinecapableoflongsurvivalandexpressinghumanNT-3tolayafoundationforfutureanimalandhumancochleargenetransfectionresearch.MethodsWecollectedlymphocytesfromnormalhumanbloodviaFicollfluidandaddedIL-2intotheserumculturemediumtopromotelymphocytegrowth.TheNT3cDNAwasobtainedbyRT-PCRandligatedwiththeeukaryonvectorwhichispIRES-DsRed2usingT4DNAenzyme.TheNT3cDNAgenewastransfectedintothelymphocytelineusingcationicliposome(LP2000).ThelymphocytestransfectedwithNT3-cDNAwereexaminedbyRT-PCRandWestern-blotmethods.ResultsWeestablishedanewmethodtoextendinvitrolymphocytessurvivaltimeandtotransfectNT3intolymphocytes.Thegeneticallyengineeredlymphocyteswerecapableofsurvivingoverrelativelylongtime.PositiveproteinsignalswereobtainedbyWesternblot.ConclusionsUsinglymphocytesastheintermediary,recombinedplasmidpIRES-DsRed2NT3isusedtoestablishalymphocytelinethatexpressesandsecretesNT3.Thiscelllinecanbeusedinfutureanimalgenecochleartransfectionresearchandmayhelpfindanintermediarycelllineforgenetherapyforhumandeafness.

简介：本文提出助听器技术发展的3．0版，其目的是希望从宏观角度更好地例述助听器技术的发展现状及未来。助听器从听得到，到听得清楚再到听得舒服和自然，代表，听力康复技术和理念进化的全过程。只有了解这一过程，才能感受新技术和新膨用的伏效性，才能做好充分准箭娅接助听器的下一个发展阶段。

简介：摘要目的口腔颌面创伤骨折的临床治疗分析。方法本文选取我院于2014年01月~2015年05月收治的92例口腔颌面创伤骨折患者，将其随机分为治疗组和对照组，对照组采用闭合复位固定手术疗法，治疗组采用切开复位内固定手术疗法，对比两组患者的临床疗效以及不同年龄段患者的愈合结果。结果一共有78例患者口腔颌面创伤愈合，其中小于25岁患者的愈合率为93.75%，25岁-60岁之间患者的愈合率为88.89%，大于60岁患者的愈合率为53.33%，其中大于60岁患者的愈合率明显低于小于60岁患者的愈合率，结果对比存在显著性差异（P<0.05），具有统计学意义。结论口腔颌面创伤骨折患者采用切开复位内固定手术疗法后，可以有效提升治疗效果，使得患者更快、更好的恢复正常口腔颌面功能以及面部外形。