简介：目的：探讨中老年人群高脂血症、糖尿病与年龄相关性白内障（age-relatedcataract,ARC）的关系。方法：采用以医院为基础的病例对照研究方法,病例组由年龄45～85岁的360例ARC患者所组成;对照为与病例同期入住相同医院,未患与ARC有关眼病的360例患者,对照组与病例采取1：1匹配方式。采用自行设计的调查表对研究对象进行调查,内容包括人口学特征、生活方式、疾病既往史等,同时收集研究对象的临床生化检测资料,包括空腹血糖、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）及甘油三酯（TG）等。采用多因素Logistic回归分析,估计研究因素与ARC关联的比值比（OR）及其相应的95%可信区间（CI）。结果：调整了年龄和性别因素后,高脂血症、高脂血症病程、TC及TG与发生ARC的危险性无关（P〉0.05）,仅HDL-C下降与发生ARC的危险性升高有关（OR=1.519,95%CI：1.093～2.110,P=0.013）。在调整了多种潜在性混杂因素后,经多因素Logistic回归分析的结果显示,空腹血糖受损的研究对象发生ARC的危险性升高了73%（OR=1.734,95%CI：1.102～2.725,P〈0.001）,而已确诊的糖尿病患者发生ARC的危险性升高了94%（OR=1.938,95%CI：1.293～2.906,P〈0.001）。糖尿病病程也与ARC呈显著性正相关,糖尿病病程〈10a和10～19a的病例发生ARC的危险性分别是未患糖尿病对照的2倍（OR=2.347,95%CI：1.502～3.752,P=0.010）和3倍（OR=2.683,95%CI：1.267～5.683,P〈0.001）。结论：HDL-C下降及糖尿病可使中老年人群发生ARC的危险性增加。

简介：AIM:Toinvestigatetheaccuracyofintraocularpressure(IOP)asmeasuredbyaReichertOcularResponseAnalyzer(ORA),aswellastherelationshipbetweencentralcornealthickness(CCT)andIOPasmeasuredbyORA,Goldmannapplanationtonometry(GAT),anddynamiccontourtonometry(DCT).·METHODS:Atotalof158healthyindividuals(296eyes)werechosenrandomlyformeasurementofIOP.AfterCCTwasmeasuredusingA-ultrasound(A-US),IOPwasmeasuredbyORA,GAT,andDCTdevicesinarandomizedorder.TheIOPvaluesacquiredusingeachofthethreetonometrieswerecompared,andtherelationshipbetweenCCTandIOPvalueswereanalyzedseparately.TwoIOPvalues,Goldmann-correlatedIOPvalue(IOPg)andcorneal-compensatedintraocularpressure(IOPcc),weregotusingORA.ThreegroupsweredefinedaccordingtoCCT:1)thincornea(CCT<520μm);2)normal-thicknesscornea(CCT:520-580μm);and3)thickcornea(CCT>580μm)groups.·RESULTS:Innormalsubjects,IOPmeasurementswere14.95±2.99mmHgwithORA(IOPg),15.21±2.77mmHgwithORA(IOPcc),15.22±2.77mmHgwithGAT,and15.49±2.56mmHgwithDCT.Meandifferenceswere0.01±2.29mmHgbetweenIOPccandGAT(P>0.05)and0.28±2.20mmHgbetweenIOPccandDC(P>0.05).TherewasagreatercorrelationbetweenIOPccandDCT(r=0.946,P=0.000)thanthatbetweenIOPccandGAT(r=0.845,P=0.000).DCThadasignificantcorrelationwithGAT(r=0.854,P=0.000).GATwasmoderatelycorrelatedwithCCT(r=0.296,P<0.001),whileIOPccshowedaweakbutsignificantcorrelationwithCCT(r=0.155,P=0.007).TherewasastrongnegativecorrelationbetweenCCTandthedifferencebetweenIOPccandGAT(r=-0.803,P=0.000),withevery10increaseinCCTresultinginanincreaseinthisdifferenceof0.35mmHg.Thethickcorneagroup(CCT>580μm)showedtheleastsignificantcorrelationbetweenIOPccandGAT(r=0.859,P=0.000);whilethethincorneagroup(CCT<520μm)hadthemostsignificantcorrelationbetweenIOPccandGAT(r=0.926,P=0.000).ThecorrelateddifferencesbetweenIOPccan