简介：Anewtypeoffiberopticglucosebiosensorbasedonfluorescencequenchinghasbeendesignedanditspropertieshavebeenstudied.Glucosecanbeoxidizedbyoxygenwhenglucoseoxidaseareusedasthecatalyst,therefore,theconcentrationofglucosecanbemeasuredbydetectingtheconsumptionofoxygen.Forthedetectionofoxygenconcentration,theruthenium(Ⅱ)complex,Ru(bpy)3Cl2,wereusedasthefluorescenceindicatoranditsfluorescencelifetimeweredetectedbylock-intechnology.Thedetectingrangeofthesensoris50-500mg/dlanditsresponsetimeis30seconds,showingthatthiskindofsensorsispossibletobeusedinclinicaldiagnosisanddetection.

简介：InthisLetter,aminiaturewearableRamanspectroscopysystemisdeveloped.Awearablefiber-opticprobeiemployedtohelpthestableandconvenientcollectionofRamanspectra.Anonlinearpartialleastsquaresmodebasedonamultivariatedominantfactorisemployedtopredicttheglucoselevel.Themeancoefficientsofdeterminationare0.99,0.893,and0.844fortheglucosesolution,laboratoryrats,andhumanvolunteers.ThresultsdemonstratethataminiaturewearableRamanspectroscopysystemisfeasibletoachievethenoninvasivdetectionofhumanbloodglucoseandhasimportantclinicalapplicationvalueindiseasediagnosis.