简介：Enhanced2.7μmemissionisobtainedinEr3+/Tm3+andEr3+/Ho3+codopedZBYAglasses.Absorptionandemissionspectraaretestedtocharacterizethe2.7μmemissionpropertiesofEr3+/Tm3+andEr3+/Ho3+dopedZBYAglassesandareasonableenergytransfermechanismof2.7μmemissionbetweenEr3+andTm3+Ho3+)ionisproposed.CodopingofTm3+orHo3+significantlyreducesthelifetimeoftheEr3+:4I13/2levelduetotheenergytransferofEr3+:4I13/2→Tm3+:3F4orEr3+:4I13/2→Ho3+:5I7.Thus,the2.7μmemissionisstrengthenedandthe1.5μmemissionisdecreasedaccordinglyespeciallyintheEr3+/Tm3+sample.TheupconversioneffectsbetweentheEr3+/Tm3+andEr3+/Ho3+dopedZBYAglassesaredifferentattributetothedifferentenergytransferefficiencies.Bothofthetwocodopedsamplespossessnearlyequallargeemissioncrosssection(16.6×10-21cm-2)around2.7μm.TheresultsindicatethatthisEr3+/Tm3+orEr3+/Ho3+dopedZBYAglasshaspotentialapplicationsin2.7μmlaser.

简介：肿瘤是严重威胁人类健康和生命的第二大疾病,尽管已发展多种治疗方法,目前仍然是医学界所面临的挑战之一。针对癌症发生的根源,我们发展了新型激光免疫疗法。激光免疫疗法有效结合光热靶向治疗和免疫治疗,通过局部肿瘤损伤,激发宿主免疫防御系统,诱导宿主产生特异性抗肿瘤免疫反应。临床前和初步临床研究表明,激光免疫疗法能够有效地治疗转移肿瘤,并在对晚期恶性黑色素瘤患者及乳腺癌患者治疗中取得令人满意的疗效。基于原位自体全细胞抗肿瘤疫苗的原理,激光免疫疗法能够局部产生全细胞疫苗,诱发机体系统、长期的抗肿瘤免疫反应。本文将介绍激光免疫疗法的发展及临床应用。

简介：骆清铭、张智红、赵元弟、杨杰、罗若愚等人完成的“用于药物筛选和药效评价的光学分子成像动态监测理论与方法研究”项目针对在药物筛选与药效评价应用中存在的问题，从系统生物学角度出发，通过探索生物分子信息的建模、仿真与信号处理新理论与新方法，开发多元化的荧光分子探针，建立适合于长时程动态光学成像的细胞网络和实验动物模型，发展高时空分辨、高通量、高灵敏度的光学分子成像技术，形成了从光学分子探针、细胞与动物模型、光学成像监测装置到生物分子信息可视化的理论和技术体系，建立了可用于药物筛选和药效评价的光学分子成像动态监测平台。

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简介：MonovalentionsLi+,Na+,andK+,aschargecompensators,areintroducedintoCaYAl3O7:M(M=Eu3+,Ce3+)inthisletter.TheircrystalphasesandphotoluminescencepropertiesofdifferentalkalimetalionsdopedinCaYAl3O7areinvestigated.Inaddition,theinfluenceofchargecompensationionLi+whichhasamoreobviousroleinimprovingluminescenceintensityonCaYAl3O7:Eu3+phosphorisintentionallydiscussedindetailandapossiblemechanismofchargecompensationisgiven.Theenhancementofredemissioncenteredat618nmbelongingtoEu3+isachievedbyaddingalkalimetalionLi+under393-nmexcitation.

简介：传统的分子材料具有均一性高、溶解性好以及易于加工与复台等优良特性，但由于其构成分子的尺寸太小，很难表现出纳米粒子所具有的特异的光学、电学和磁学等性质。由于制备方法的限制，目前纳米材料的研究局限在具有一定粒径或分子量分布的纳米粒子所构成的混合物体系，因而阻碍了对介观现象及其本质的深入认识，限制了材料性能的进一步提高。

简介：Er~(3+)-dopedphosphor-telluriteglassforbroadbandshort-lengthEr~(3+)-dopedfiberamplifier(EDFA)isfabricatedandcharacterized.Thedifferentialvalue(△T)ofonsetcrystallinetemperature(T_x)andglasstransitiontemperature(T_g)is206°C.ThestimulatedemissioncrosssectionofEr~(a+)iscalculatedfromab-sorptionspectrumbyMcCumbertheoryandis0.87×10~(-20)cm~2at1532nm.Abroad1.5-μmfluorescencespectrumwith54-nmfull-widthathalfmaximum(FWHM)isdemonstrated.Especially,themaximumphononenergyofundopedphosphor-telluriteglassis1100cm~(-1),whichrestrictstheupconversionlumines-cence.Itispossibletopumpefficientlyat980nm.TheseresultsindicateEr~(3+)-dopedphosphor-telluriteglassissuitableforfabricatingbroadbandshort-lengthEDFA.

简介：血片镜检可以实现白细胞的分类计数,同时还能提供详细的白细胞形态等特征,有助于疾病的诊断。目前国内大多数医院白细胞检测的主要方法是人工镜检,但人工镜检依赖医务人员的工作经验,劳动强度大,检测效率低。因此提出一种基于RGB彩色空间分量差的白细胞细胞核的快速分割方法。通过显微镜分析人体外周血液涂片的显微图像,发现白细胞细胞核区域的B分量和G分量的差值明显比其他区域大,可以通过一个简单8bit的B-G运算,来实现五类白细胞细胞核的快速分割,白细胞细胞核的平均分割时间为0.26ms,体现了较好的鲁棒性和实时性。该方法成功应用到白细胞的实时在线自动扫描镜检中,提高了镜检的效率。

简介：首先叙述了光纤传输Nd3+:YAG激光的优点,接着分析了不同光纤和其传输Nd3+:YAG激光的特点.然后通过对光纤传输系统各部分的分析与设计,结合实际,设计了光纤耦合机构.最后,对来自于工件反射光问题提出了解决方案.

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简介：本刊讯强场非顺序双电离包含了丰富的物理过程，最重要的是为研究电子关联效应提供了一个简单清晰的模型，因而成为当前强场物理领域研究的热点。在分子与强场的相互作用过程中，电离和解离会同时发生。实验和理论研究表明核间距的变化会对分子电离产生重要影响。

简介：Nitridatedβ-Ga_2O_3(100)substratewasinvestigatedasthesubstrateforGaNepitaxialgrowth.Theeffectsofnitridationtemperatureandsurfaceroughnessofβ-Ga_2O_3wafersontheformationofGaNwerestudied.Itwasfoundthatthemostoptimizednitridationtemperaturewas900°C,andhexagonalGaNwithpreferredorientationwasproducedonthewell-polishedwafer.Thenitridationmechanismwasalsodiscussed.

简介：ApassivelyQ-switchedNd3+:YAGlaserwithcornercubeistheoreticallyandexperimentallystudied.Weanalyzethepolarizationvariationincavityandsimulatethepeakpower,pulseenergyandpulsewidthchangedwiththerotationangleofcornercubenumerically.Anexperimentismadetoverifythetheoreticalresults.Withrotatingtheangleofcornercubeabouttheaxisthevariationrangeofpeakpoweris1.77MW(from10.36to8.59MW),andthatofpulseenergyis14.9mJ(from159.5to174.4mJ),thefluctuationofpulsewidthis2.95ns.Theexperimentalresultsagreewiththetheoreticalanalysistotheextentofvariationrules.Themostdynamictostaticenergyratioof62.5%isachieved.

简介：Er3+-dopedheavymetalborosilicateglasseswerepreparedusingconventionalmeltingandquenchingmethod.Theemissionspectraof4Ⅰ13/2→4Ⅰ15/2transitionwereobserveduponexcitationat974nmandthelifetimeof4Ⅰ13/2levelofEr3+wasmeasured.Basedonthesedata,thefluorescencepropertiesofEr3+areinvestigatedontheemissionandgaincharacteristicsatthe1.5μmbands.Inparticular,theeffectofrelativeheavymetalcontentonfluorescencepropertiesisdiscussed.

简介：Anewscreen-spotimagingmethodbasedonopticalmeasurementisproposed,whichisapplicabletotheclose-rangemeasurementofaircraft'sthree-dimensional(3D)attitudeparameters.Lasertrackerisusedtofinishtheglobalcalibrationsofthehigh-speedcamerasandthefixedscreensontestsite,aswellastoestablishmedia-coordinate-framesamongvariouscoordinatesystems.Thelasercooperationobjectmountedontheaircraftsurfaceprojectslaserbeamsonthescreensandthehigh-speedcamerassyn-chronouslyrecordthelight-spots'positionchangingwithaircraftattitude.Therecordedimagesequencesareusedtocomputetheaircraftattitudeparameters.Basedonthematrixanalysis,theerrorsourcesofthemeasurementaccuracyareanalyzed,andthemaximumrelativeerrorofthismathematicalmodelisestimated.Theexperimentalresultshowsthatthismethodeffectivelymakesthechangeofaircraftpositiondistinguishable,andtheerrorofthismethodisnomorethan3′whiletherotationanglesofthreeaxesarewithinacertainrange.

简介：Anovelno-guidelightpentype3D-coordinatemeasurementsystemwiththreesetsofpositionsensitivedevices(PSDs)torealizeintersectionconvergeinagingisintroduced.Itiscalledasthelightpentypemeasurementsystem,becausethemeasuringheadisshapedasapenwithseverallightsourcesonit.Thestructuredesign,measurementprincipleandexperimentalresultsarepresented.Thetheoreticalanalysisandexperimentalresultsprovethatthissystemhasadvancedfeaturesofsimplestructure,highautomation,andhighaccuracy,andcanbeusedinthemeasurementfieldsofmechanicalmanufacture,robot,auto,aviationandmedicineeffectively.

简介：WhenfemtosecondlaserpulsesinterferewithchirpedfemtosecondlaserpulsesinAs2S3fiber,achirpedfibergratingisformed.Ananalyticalexpressionisgiventodescribethechirpedgrating,anditsBraggreflectivityiscalculated.BecauseofthehighphotosensitiveeffectofAs2S3material,thechirpedfibergratinghasawideBraggreflectivespectrumandhighreflectivitybychoosingproperparameters.Thisindicatesthatthechirpedfibergratingcanbeusedasastretcherinthefemtosecondchirpedpulseamplification(CPA)system.

简介：ACe3+tion-dopedα-NaYF4singlecrystalofhighqualityisgrownsuccessfullybyanimprovedfluxBridgmanmethodundertheconditionsoftakingthechemicalrawcompositionofNaF:KF:YF3:CeF3inthemolarratioof30∶18∶48∶4,wheretheKFisshowntobeaneffectiveassistantflux.Thexraydiffraction,absorptionspectra,excitationspectra,andemissionspectraoftheCe3+t-dopedα-NaYF4singlecrystalaremeasuredtoinvestigatethephaseandopticalpropertiesofthesinglecrystals.TheabsorptionspectrumoftheCe3+t:α-NaYF4showsastrongbandthatpeaksatthewavelengthof300nm.TheemissionspectrumoftheCe3+t:α-NaYF4emitsanintenseultraviolet（UV）bandatthewavelengthof332nmundertheexcitationof300nmlight.Twoseparatedluminousbandsof330and350nm,whichcorrespondtothetransitions5d→2F25∕2and5d→F7∕2,canbeobtainedbyGaussfitting.ThestrongemissionintensityattheUVbandandtheexcellentopticaltransmissionintherangeofUVwavelengthsindicatethatCe3+t:α-NaYF4singlecrystalscanbeconsideredasapromisingmaterialforUVlasers.

简介：Toobtainhighpower589-nmyellowlaser,aT-shapedthermal-insensitivecavityisdesigned.Theoptimalpowerratioof1064-and1319-nmbeamsisconsideredandthefundamentalspotsizedistributionfromtheoutputmirrortothetwolaserrodsarecalculatedandsimulated,respectively.Asaresult,a589-nmyellowlaserwiththeaverageoutputpowerof5.7Wisobtainedintheexperimentwhenthetotalpumpingpoweris695W.Theoptical-to-opticalconversionefficiencyfromthefundamentalwavestothesumfrequencygenerationisabout15.2%andthepulsewidthis150nsattherepetitionrateof18kHz.Theinstabilityoftheyellowlaserisalsomeasured,whichislessthan2%within3h.ThebeamqualityfactorsareM_x~2=4.96andM_v~2=5.08.

简介：TheCa_2SiO_4:Dy~(3+)phosphorwassynthesizedbythehightemperaturesolid-statereactionmethodinair.TheemissionspectrumofCa_2SiO_4:Dy~(3+)phosphorshowsseveralbandsat486,575,and665nmunderthe365-nmexcitation.TheeffectsofLi~+,Na~+,andK~+ontheemissionspectrumofCa_2SiO_4:Dy~(3+)phosphorwerestudied,TheresultsshowthattheemissionspectrumintensityisgreatlyinfluencedbyLi~+,Na~+,andK~+.Thechargecompensationconcentrationcorrespondingtothemaximumemissionintensityisdifferentwithdifferentchargecompensations.