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简介：AbstractGenomoviridae is a virus family belonging to circular replication associated protein encoding ssDNA (CRESS-DNA) viruses, which have diverse genomic architecture and are widely distributed among different ecosystems. In this study, we characterized 39 novel genomovirus genomes including 3 from wild egrets, 9 from wild cranes, as well as 27 from wild finches in three different types of cloacal swabs of wild bird sampled in the station of Xinqing bird ringing, Maoershan Nature Reserve in Heilongjiang Province, Changbai Mountain in Jilin Province, and Hangzhou Wetland Park in Zhejiang Province, China. Here, using a Rep sequence phylogeny-based analysis, we divided the 39 genomoviruses into 8 genera within the family Genomoviridae, including Gemycircularvirus (n =20), Gemykibivirus (n =3), Gemygorvirus (n =2), Gemyvongvirus (n =2), Gemykolovirus (n =3), Gemykrogvirus (n =6), Gemytondvirus (n=1), Gemyduguivirus (n=1) and one unclassified genomovirus. The 39 genomovirus genomes belong to 36 species (27 of which are new) based on the currently accepted genomovirus pairwise nucleotide sequence identity species demarcation threshold of 78%. Overall, the research enriches our knowledge of CRESS-DNA viral diversity in China and emphasizes the prevalence of genomoviruses in nature.

简介：Wnt-1induciblesignalingpathway-1(WISP-1),alsoknownasCCN-4,belongstotheconnectivetissuegrowthfactor(CTGF)family.WISP-1isprimarilyexpressedinembryonicstemcellsandisinvolvedinadultorgandevelopment.WISP-1participatesinmanycellularprocesses,includingproliferation,differentiation,apoptosisandadhesion.Inaddition,WISP-1playsanimportantroleindiversepathophysiologicalprocesses,suchasembryonicdevelopment,inflammation,injuryrepairsandcancers.RecentstudiesshowedthatWISP-1washighlycorrelatedwithtumorprogressionandmalignanttransformation,whereasitplayedanoncogenicroleincolorectalcancer,cholangiocarcinoma,hepatocellularcarcinomaandbreastcancer.However,interestingly,WISP-1exertsatumorsuppressingroleinlungandprostatecancers.WISP-1promotescellproliferation,adhesion,motility,invasion,metastasisandepithelial-to-mesenchymaltransitionviaparticularsignalingpathways.Inthisreview,wediscussedthestructure,expressionprofile,functions,clinicalsignificanceandpotentialmechanismsofWISP-1incancerandnon-neoplasticdiseases.

简介：维生素D3起来调整的蛋白质(VDUP1)1是涉及维持细胞的动态平衡的多功能的蛋白质。VDUP1被许多压力导致。相反地，VDUP1经常在各种各样的肿瘤纸巾和房间线被减少。VDUP1的在表示上通过房间周期拘捕禁止房间增长。VDUP1与thioredoxin(Trx)交往并且否定地调整表示和涉及氧化还原作用规定的Trx的抗氧化剂功能。VDUP1-/-鼠标比野类型的鼠标更产生carcinogenesis并且在包括自然漂亮房间的开发和函数建立免疫系统是有缺点的。而且，VDUP1-/-mice表演损害了Kreb调停周期的丰满的酸利用。在这评论，我们在多样的细胞的回答，特别地与增长的它的关系，apoptosis，区别，和象癌症那样的疾病和压力相关的疾病讨论了VDUP1的多功能的角色。

简介：前列腺癌症是全球癌症相关的死亡的一个领先的原因，但是试图改善诊断并且开发新奇治疗被重要耐心的异质惊讶。在最近的年里，到几百个前列腺瘤的下一代的定序的应用程序定义新奇分子的子类型并且描绘了位于疾病开始和前进下面的广泛的genomic错误。在诊所观察的异质是由与复杂性流行的一处分子的风景的underpinned，现在是清楚的，在genomic重新整理和稀罕变化联合放大transcriptomic差异的地方。这评论把我们前列腺癌症‘的当前的理解；omic的包括拷贝数字变化的哨兵角色，oncogenic熔化基因，chromothripsis的潜在的影响，和在定义联系变化的子类型的突破的成长光谱。增加的证据建议损害经常在特定的细胞的功能和发信号的小径上集成的那genomic，还周期性的基因错误显得稀罕。因此，我们继续定义单个瘤染色体，是批评的，特别在他们的表示transcriptome的上下文。仅仅通过到瘤可变性罐头的瘤的改进描述，我们前进到精确治疗和个性化的肿瘤学的年龄。