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简介：AbstractMucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales. The number of individuals with mucormycosis-causing disorders has increased in recent years, hence, leading to the spread of mucormycosis. Throughout the coronavirus disease 2019 (COVID-19) pandemic, numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide, and the illness is now recognized as COVID-19-associated mucormycosis, with most of the cases being reported from India. Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis. Genes, pathways, and other mechanisms have been studied in Mucorales, demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets. This review discusses several proteins such as high-affinity iron permease (FTR1), calcineurin, spore coat protein (CotH), and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s) for the development of novel diagnostic and therapeutic methods.

简介：AbstractIn order to effectively implement the Tianjin Biosecurity Guidelines for Codes of Conduct for Scientists, biosecurity awareness-raising and education are essential because if these are not in place scientists will not understand the need for biosecurity codes of conduct. In an effort to assist in the implementation of the guidelines, a small-scale survey was carried out in early 2022 of biosecurity awareness-raising and education projects that have been developed over the last two decades to discover what resources and experience have been accumulated. It is argued that the survey demonstrates that much of what is needed to implement the guidelines effectively has been developed, but that there are specific deficiencies that need to be remedied quickly. In particular, an updated teaching resource covering the core issues related to the Biological and Toxin Weapons Convention (BTWC) and the problem of dual use in scientific research needs to be made widely available and translated into at least the six official United Nations (UN) languages. Additionally, more specialists from the Humanities with expertise in ethics need to become involved in biosecurity awareness-raising and education activities. While advantage should be taken now of the available national, regional and international networks of people involved in related activities, it is suggested that in the longer term cooperation in biosecurity awareness-raising and education will benefit from the development of an equivalent organisation to the International Nuclear Security Education Network (INSEN) organised through the International Atomic Energy Agency (IAEA).

简介：AbstractBackground:Zoonoses are public health threats that cause severe damage worldwide. Zoonoses constitute a key indicator of One Health (OH) and the OH approach is being applied for zoonosis control programmes of zoonotic diseases. In a very recent study, we developed an evaluation system for OH performance through the global OH index (GOHI). This study applied the GOHI to evaluate OH performance for zoonoses in sub-Saharan Africa.Methods:The framework for the OH index on zoonoses (OHIZ) was constructed including five indicators, 15 subindicators and 28 datasets. Publicly available data were referenced to generate the OHIZ database which included both qualitative and quantitative indicators for all sub-Sahara African countries (n = 48). The GOHI algorithm was used to estimate scores for OHIZ. Indicator weights were calculated by adopting the fuzzy analytical hierarchy process.Results:Overall, five indicators associated with weights were generated as follows: source of infection (23.70%), route of transmission (25.31%), targeted population (19.09%), capacity building (16.77%), and outcomes/case studies (15.13%). Following the indicators, a total of 37 sub-Sahara African countries aligned with OHIZ validation, while 11 territories were excluded for unfit or missing data. The OHIZ average score of sub-Saharan Africa was estimated at 53.67/100. The highest score was 71.99 from South Africa, while the lowest score was 40.51 from Benin. It is also worth mentioning that Sub-Sahara African countries had high performance in many subindicators associated with zoonoses, e.g., surveillance and response, vector and reservoir interventions, and natural protected areas, which suggests that this region had a certain capacity in control and prevention or responses to zoonotic events.Conclusions:This study reveals that it is possible to perform OH evaluation for zoonoses in sub-Saharan Africa by OHIZ. Findings from this study provide preliminary research information in advancing knowledge of the evidenced risks to strengthen strategies for effective control of zoonoses and to support the prevention of zoonotic events.

简介：AbstractBackground:Being able to predict with confidence the early onset of type 2 diabetes from a suite of signs and symptoms (features) displayed by potential sufferers is desirable to commence treatment promptly. Late or inconclusive diagnosis can result in more serious health consequences for sufferers and higher costs for health care services in the long run.Methods:A novel integrated methodology is proposed involving correlation, statistical analysis, machine learning, multi-K-fold cross-validation, and confusion matrices to provide a reliable classification of diabetes-positive and -negative individuals from a substantial suite of features. The method also identifies the relative influence of each feature on the diabetes diagnosis and highlights the most important ones. Ten statistical and machine learning methods are utilized to conduct the analysis.Results:A published data set involving 520 individuals (Sylthet Diabetes Hospital, Bangladesh) is modeled revealing that a support vector classifier generates the most accurate early-onset type 2 diabetes status predictions with just 11 misclassifications (2.1% error). Polydipsia and polyuria are among the most influential features, whereas obesity and age are assigned low weights by the prediction models.Conclusion:The proposed methodology can rapidly predict early-onset type 2 diabetes with high confidence while providing valuable insight into the key influential features involved in such predictions.

简介：摘要：随着社会的不断发展和进步，城市化进程的加快，园林绿化工程对于我国的城市建设起着越来越重要的作用。在园林绿化施工过程中，反季节施工是最较为常见的施工工艺，在进行反季节施工时，要遵循一定的规则，遵守绿植的生长习性，在合适的时间进行反季节栽植。利用反季节施工技术，能够突破季节对种植绿化的影响，加快施工进度，缩短施工工期，在最短的时间的完成园林景观效果。本文从优化城市形象、改善生活环境以及提升绿化水平几方面着手，阐述了反季节施工技术的重要性，阐述园林绿化工程反季节施工存在的问题提出了几点应对策略，为我国城市园林绿化工程高质量建设创造良好的条件。

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简介：【摘要】我国目前各地教育水平，由于受经济、地域、文化等因素的影响，差距过大，极其不均衡。为了落实党的教育方针，教育必须为社会主义现代化建设服务，为人民服务，必须与生产劳动和社会实践相结合，培养德、智、体、美和劳全面发展的社会主义建设者和接班人。提高国民素质，培养国民的创新能力。国家从我国的国情出发，制定了教育均衡发展方针，先后提出并实施“县管校聘”和“轮岗制”两种有利于教育均衡发展的制度。

简介：摘要：集箱是电站锅炉的核心部件，在电站锅炉运行发电过程中环境要求高，产品需要承受高温高压和蒸汽的冲刷，所以对集箱产品的制造过程中的质量要求非常高，同时由于集箱的生产流程、周期较长，焊接的质量不仅影响产品的整体质量、增加生产经营成本、导致产品的流速放缓，还对生产任务起着很强的制约作用。 因此，急需解决实际生产中遇到的焊接质量问题。

简介：摘要：立体构成又被称为空间构成，是用一定的材料、以视觉为基础，力学为依据，将造型元素按照一定的组合规律，排列成其他形态的组合方式。探索立体构成的本质规律，发现立体设计的本质原则。如何在多维的空间中，将立体构成的元素按照某种特定的规律进行排列组合，从而展现出形态特色美，是这门学科所要展现出的魅力。

简介：摘要：动机决定行为，动机是自利的，而自利要遵循帕累托改进原则。手段必须与动机相一致。财富是满足生理需求的物质资料，是达到目的的手段，游戏是满足精神需求的活动，是非营利的。博彩是异化的游戏，是谋财的偏门。博彩具有一定意义的合法性。它是经济体系中的淋巴结，是必要之恶。经济体越健康，博彩业越冷清。

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简介：摘要：随着社会的发展，我国的经济不断提升，当前城镇化速度也不断加快，但是在这一社会背景下也随之出现了各种城市问题，主要包括水涝、水资源缺乏、生态环境破坏、雨水径流污染等，种种不良问题都将会影响着我国城市的发展，并且对广大人民群众的出行形成一定困扰，而通过采用“海绵城市”理念将会促进城镇建设工作的开展。在城市化进程的强大推动下，促进了海绵城市理念的应用，对城市水土保持设计工作的开展产生了深远影响。在城市水土保持设计中，加强海绵城市理念的应用，可以有效处理和解决水土流失问题，促进水土保持设计工作顺利进行，确保良好的防治效果。

简介：摘要：上世纪二三十年代，布加迪在法拉利崛起之前一直雄霸天下，在世界跑车车坛里占据着不可动摇的地位。随着二战的到来，布加迪低调了一段时间。但是，战后在大众汽年公司的大力扶持之下，布加迪重出江湖。此时，布加迪已经正式隶属于大众奥迪旗下，并且自1998年起连续推出数款堪称经典的概念车，迅速恢复了布加迪品牌在世界上的盛誉。布加迪的SUV车型是我所喜欢的，以下为我对布加迪威龙的相关了解。

简介：摘要：说起地摊，很容易联想到古时历朝历代的街市，临街而起，车水马龙，映衬出一座城市的繁华与兴旺。一如“清明上河图”，人间的烟火，中国的生机。地摊经济就是最早的农贸市场，为搞活农产品流通，增加农民收入，丰富城市居民的“菜篮子”，发挥了重要作用，为我国社会当时的发展做出了重大贡献。地摊经济既是一个民生问题，也是一个经济问题。国家放宽占道经营，不仅增加了大量的就业岗位，也给各类群体创造出了更多的就业空间，为经济发展打下了一定基础。

简介：【摘要】2022年3月，上海迎战空前严峻复杂的新一波疫情。核酸检测作为疫情防控中的重要环节之一，为打赢大上海保卫战奠定了重要基础。核酸采样工作中的每个细节和注意事项，都需要认真对待。常态化核酸检测任重道远。

简介：摘要：随着时代的不断发展，我国光伏发电技术也发生了不同程度的变化，现在人们对电力需求比较高，光伏技术可以在推动社会经济发展的同时，保护周围的生态效益。因此如何将光伏技术的价值发挥到最大，成为人们比较关注的话题。本文主要分析了提高并网光伏电站运维管理的策略，希望可以给工作人员提供一些帮助和思考。

简介：摘要：小建中汤为治疗虚劳里急的重要方剂。在《金匮要略心典》中，尤怡更是将它称为‘立中气以和阴阳’之方。本文将从其名称、组成配伍、应用方面来浅析小建中汤。

简介：摘要：教育的根本任务是立德树人，近年来由于各种社会因素的影响，教育越来越偏离其根本宗旨，教育生态不断恶化。对此，国家重拳出击，推出“双减政策”。双减政策是解决我国教育乱象的一个重要举措。双减政策在整治教育乱象、化解家校矛盾、促进学生身心健康方面能起到积极作用，并在夯实教育基础、促进教育公平、打破阶层固化等方面具有重要意义。

简介：摘要：在轨道交通装备行业列车车辆制动系统防滑保护功能是车辆运营安全的重要功能，本文主要地铁车辆防滑保护功能进行阐述，分析防滑保护工作原理，描述防滑保护功能发挥的作用，将列车车辆在正常工况下的制动试验与在非正常工况下车辆制动系统发挥防滑保护功能的试验进行对比，阐述列车防滑保护功能的重要性。