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简介：Thepresentstudywasdesignedtoexaminetheanti-hyperuricemicandanti-inflammatoryeffectsandpossiblemechanismsofvaticaffinol,aresveratroltetramerisolatedfromethanolextractsofDipterocarpusalatus,inoxonate-inducedhyperuricemicmice.At1hafter250mg·kg~(-1)potassiumoxonatewasgiven,vaticaffinolat20,40,and60mg·kg~(-1)wasintragastricallyadministeredtohyperuricemicmiceoncedailyforsevenconsecutivedays.Vaticaffinolsignificantlydecreasedserumuricacidlevelsandimprovedkidneyfunctioninhyperuricemicmice.Itinhibitedhepaticactivityofxanthinedehydrogenase(XDH)andxanthineoxidase(XOD),regulatedrenalmRNAandproteinlevelsofuratetransporter1(URAT1),glucosetransporter9(GLUT9),organicaniontransporter1(OAT1),organiccationtransporter1(OCT1),OCT2,organiccation/carnitinetransporter1(OCTN1),andOCTN2inhyperuricemicmice.Moreover,vaticaffinolmarkedlydown-regulatedrenalproteinlevelsofNOD-likereceptor3(NLRP3),apoptosis-associatedspeck-like(ASC),andCaspase-1,resultinginthereductionofinterleukin(IL)-1β,IL-18,IL-6andtumornecrosisfactor-α(TNF-α)levelsinthisanimalmodel.Additionally,HPLCandLC-MSanalysesclearlytestifiedthepresenceofvaticaffinolinthecrudeextract.Theseresultssuggestthatvaticaffinolmaybeusefulforthepreventionandtreatmentofhyperuricemiawithkidneyinflammation.

简介：PostedonJanuary4,2017byFDAVoiceThispastyearwasanothersuccessfulyearforthenewdrugsprograminFDA’sCenterforDrugEvaluationandResearch(CDER).CDERreviewedandapproved22noveldrugs,mostofwhichhavethepotentialtoaddsignificantclinicalvalue

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简介：Anti-globalizationtrendsareinplayintheUSandWesternEuropewhereelectoratesarerecalcitranttoallowimmigrantsintotheirsocieties,nationalsovereigntyissoughtincertaingeographicareas,andthenationalmoodseekstosuppressnewlyrisingcountries'tradeanddevelopment.ThecontinuationofeconomicdownturninWesterncountriesisreinforcedbytheirinternalwealthgapandexternalcompetition.Ascapitalism'sdemandforprofitisnowbeingcritiquedalongwiththeemergentprofitprospectstobedeliveredbypendingtechnologicalprogress,thetemperofthetimescouldtemporarilyslowdownbutnotreverseglobalization.Timelydiscussionsaboutreformofinternationaleconomicorderandaboutaneffectivenationaldevelopmentmodelshouldseeksustainablesolutionsforhealthy,stableglobalizationanddevelopmentoftheworldeconomy.

简介：Thedevelopmentofcancernanotherapeuticshasattractedgreatinterestintherecentdecade.Cancernanotherapeuticshaveovercomeseverallimitationsofconventionaltherapies,suchasnonspecificbiodistribution,poorwatersolubility,andlimitedbioavailability.Nanoparticleswithtunedsizeandsurfacecharacteristicsarethekeycomponentsofnanotherapeutics,andaredesignedtopassivelyoractivelydeliveranti-cancerdrugstotumorcells.Weprovideanoverviewofnanoparticle-baseddrugdeliverymethodsandcancertherapiesbasedontumor-targetingdeliverystrategiesthathavebeendevelopedinrecentyears.

简介：Hydrationcracksofmagnesia-spinelbricksincementindustryhavebeenseriousproblemsforbothrefractoryproducersandrefractoryusersforalongtime.Whenmagnesia-spinelbricksarekeptformorethan6months,thebrickstendtohavereactionwithwaterormoistureandresultincracksandlossontheirstructuralstrength.Thosebrickscannotbeusedanymoreandcausesubstantiallossfortherelatedparties.In2013,theSiamRefractoryIndustryCo.,Ltd.,Thailand,successfullydevelopedandappliedaspecialnano-technologytocreate'Anti-HydrationMagnesia-SpinelBricks'forcementindustrywhichcanhavethestoragetimemorethantwoyearseveninhighhumidityareas.Thecementproducerscanensurethatallbricksstillhavegoodpropertiesasthenewones.

简介：Pyrimidinederivativeshavebeenreportedasneuroprotectiveagentsusefulforthetreatmentofvariousneurodegenerativedisorders.Inthepresentstudy,severalpyrimidineanalogueshavebeenevaluatedasneuroprotectiveagentsinMorriswatermazemodel.Itwasobservedthatpyrimidinederivatives8–17considerablyimprovelearning,memory,andmovementdeficitsinanimalmodels.Biochemicalestimationsofbrainserumoftreatedanimalsrevealedsuppressionofoxidativeandnitrosativestress,acetylcholinesteraseactivity,andotherparameterswhichleadstoneurodegenerationofbrain.Ofallthepyrimidinederivatives,thiomorpholinederivative8andpiperazineethanolderivative17werefoundtobethemostactiveneuroprotectiveagentsandproducedeffectscomparabletostandarddrugrivastigmineintermsofbehavioral,biochemical,andmolecularaspects.

简介：＂Anti粉＂,即对偶像及其粉丝做出极端行为、伤害行为的另类的粉丝。＂Anti粉＂对其对象具有相当大的粘性与忠贞度,但却带有极其强烈的负面情绪,并付诸行动。从特点和成因来看,＂Anti粉＂仍然是粉丝,可以将其放置在受众研究和粉丝研究的理论谱系中加以考量。从本研究的访谈中可以看出,个体通过群体共同的喜爱、排斥或敌对行为完成了某种身份认同。＂Anti粉＂实际上是粉丝的另一面,其背后的动因在于强烈的差异化的情感力量,其根源在于现代工业化社会导致的传统社群的衰落和消失;粉丝/黑粉活动营造的紧密的社群氛围满足了碎片化、原子化生存的个体对社群生活的需要。互联网新媒介的发展不仅促进了粉丝文化的发展,同时也加剧了粉丝社群之间的区隔,一定程度上催生了极端的＂Anti粉＂行为。这种激情表达具有政治性,＂Anti粉＂及其反对的人或事都代表了一定的意识形态,这也正反映了当下一些普遍存在的观念冲突。＂Anti粉＂实际上是社会、心理等种种合力之下的必然产物,也是深层社会情绪的某种另类的反映。

简介：AIMTo在导致的lipopolysaccharide(LPS)上调查asiatic酸(AA)的反煽动性的效果在人的角膜的上皮的房间(HCEC)的煽动性的反应.METHODSCell生存能力用数kit-8(CCK-8)的一个房间被测量试金。量的即时聚合酶链反应(qRT-PCR)被用来决定mRNAinterleukin-8(IL-8)的表示，interleukin-6(IL-6)，interleukin-1(IL-1)，肿瘤坏死factor-alpha(TNF-)，和转变生长因素--(TGF-)在HCEC。细胞内部的反应的氧种类(ROS)用ROS试金工具包被测量。谷胱甘肽(GSH)集中用全部的GSH试金工具包被测量。Akt1和Aktphosphorylation(p-Akt1)层次被西方的弄污测量，immunofluorescence.RESULTSAA在高集中导致了毒性并且显著地在20的集中刺激了HCEC的增长

简介：在最近的十年，从动物和临床的研究积累证据建议了一个足够地激活的免疫系统可以强烈扩充癌症治疗的各种各样的类型，包括光力学的治疗(太平洋夏季时间)。通过反应的氧种类的产生，太平洋夏季时间根除由触发局部性的肿瘤损坏并且导致反肿瘤免疫的肿瘤。作为反肿瘤免疫的主要部件，在太平洋夏季时间的调停房间的有免疫力的回答的参与很好在过去的十年被调查了，而体液的免疫的角色仍然保持相对未经勘探。在现在的调查，使用photosensitizerBAM-SiPc和CT26忍受肿瘤的BALB/c老鼠模型，调停房间、体液的适应有免疫力的部件能涉及太平洋夏季时间，这被表明。与脉管的太平洋夏季时间(VPDT)政体，BAM-SiPc能根除~的肿瘤70%；忍受肿瘤的老鼠和扳机能持续超过1年的反肿瘤免疫者回答。Th2cytokines的举起是在VPDT以后的检测前vivo，显示体液的回答的潜在的参与。从治好VPDT的老鼠的浆液的分析也揭示了肿瘤特定的抗体的提高的层次。而且，这浆液能有效地妨碍肿瘤生长并且保护老鼠免于进一步以一种T-cell-dependent方式重新质问。一起拿，体液的部件在BAM-SiPc-VPDT以后导致了的这些结果表演能帮助反肿瘤免疫的发展。

简介：在反脉管的endothelial生长的一个年以后与有斑点的浮肿的分辨率和foveal消沉的恢复在眼睛报导foveal厚度减小为包含中心的糖尿病的有斑点的浮肿(DME)的因素(anti-VEGF)治疗.METHODSFoveal厚度与光连贯断层摄影术被估计决定中央子字段foveal厚度(CSFT)并且在有DME的42只眼睛的有斑点的体积(CSFT>275湥獴愠?潣灭牡摥琠?敨污桴?潣瑮潲?牧畯？

简介：ScutellariaeRadix(SR),therootofScutellariabaicalensisGeorgi,isusedasanantipyreticdrugandhasbeendemonstratedtohaveanti-inflammatoryactivity.SRisdividedintotwospecifications,'KuQin'(KQ)and'ZiQin'(ZQ),foruseagainstdifferentsymptoms(upperenergizerheatorlowerportionofthetripleenergizer),accordingtothetheoryoftraditionalChinesemedicine(TCM).However,differencesintheefficaciesofthesetwospecificationshavenotbeendetermined.Inthepresentstudy,weaimedtocharacterizethedifferencesintheanti-inflammatoryactivitiesbetweenKQandZQandtoexplorehowtheirdifferencesaremanifestedinlipopolysaccharide(LPS)-inducedmacrophages.Ourresultsshowedthat,inRAW264.7cells(amousemacrophagecelllinederivedfromascites),KQandZQdisplayedanti-inflammatoryeffectsbyinhibitingthereleaseofnitricoxide(NO),inducibleNOS(iNOS),andnuclearfactor-κB(NF-κB)inadose-dependentmannerwithoutdistinction.InNR8383cells(aratalveolarmacrophagecellline),KQandZQdisplayedsimilareffectsonNO,iNOS,andNF-κBasseeninRAW264.7cells,butKQshowedahigherinhibitionrateforNOandiNOSthanthatshownbyZQatthesameconcentration.TheseresultsindicatedthatthereweredifferencesinefficacybetweenKQandZQintreatinglunginflammation.OurfindingsprovidedanexperimentalevidencesupportingthedifferentusesofKQandZQinclinic,asnotedinancientherbalrecords.

简介：Background:Thesafetyandefficacyofcoronaryarterybypassgrafting(CABG)andsecond-generationdrug-elutingstents(DESs)inpatientswithcoronaryarterydisease(CAD)remaincontroversial.ThereforeweaimedtocomparetheoutcomesofCADpatientstreatedwithCABGandsecond-generationDESs.Methods:WesystematicallysearchedthePubMed,CochraneLibrary,Ovid,andElsevierdatabases.Studiescomparingsecond-generationDESswithCABGinCADpatientswereincluded.RevMan5.3wasusedtoextractandpoolthedatafromtheapplicablestudies.Results:Sixtrials(N=6604participants)wereincludedinthismeta-analysis.AmongalloftheCADpatients,second-generationDESswereassociatedwithnodifferencesintherisksofall-causedeath[riskratio(RR)1.18,95%confidenceinterval(CI)0.98–1.43,P=0.09],cardiovasculardeath(RR1.14,95%CI0.81–1.59,P=0.45),myocardialinfarction(RR1.22,95%CI0.98–1.54,P=0.08),andstroke(RR0.83,95%CI0.59–1.17,P=0.29),butincreasedtherisksofrevascularization(RR1.95,95%CI1.66–2.30,P<0.001)andmajoradversecardiacandcerebrovascularevents(RR1.72,95%CI:1.31–2.26,P<0.001)whencomparedwithCABG.Conclusions:InthetreatmentofCADpatients,second-generationDESswasnotassociatedwithincreasedrisksofall-causedeath,cardiovasculardeath,myocardialinfarction,andstroke,butincreasedtherisksofrevascularizationandmajoradversecardiacandcerebrovasculareventswhencomparedwithCABG.

简介：AIM:Toevaluatetheefficacyandsafetyofanti-vascularendothelialgrowthfactor(VEGF)combinedwithphotodynamictherapy(PDT)versusanti-VEGFmonotherapyforpolypoidalchoroidalvasculopathy(PCV).METHODS:WeconductedaMeta-analysisof9studiestocomparetheefficacyandsafetybetweencombinedtherapyandanti-VEGFmonotherapyforPCV.TheprogramsofRevMan5.3andStata12.0wereusedtoanalyzedata.RESULTS:Thebestcorrectedvisualacuity(BCVA)incombinedtherapygroupweresignificantlybetterthanthoseofanti-VEGFmonotherapygroupat6,24and36mo,withpooledweightedmeansdifferences(WMDs)of0.12(0.06,0.18),0.25(0.12,0.38)and0.28(0.13,0.43),respectively.Thecentralretinalthickness(CRT)reductionsincombinedtherapygroupwerehigherthanthatinantiVEGFmonotherapygroupat1,3,6and9mo,withpooledWMDsof63.90(20.41,107.38),33.47(4.69,62.24),30.57(0.12,60.01)and28.00(2.51,53.49),respectively.Theregressionrateofpolypsincombinedtherapygroupwasmuchhigherthanthatinanti-VEGFmonotherapygroup[RD:0.47(0.26,0.68);P<0.0001].Theadverseeventretinalhemorrhagedidnotdiffersignificantlybetweenthetwogroups.CONCLUSION:OurfindingsclearlydocumentthatantiVEGFcombinedwithPDTisamoreeffectivetherapyforPCVcomparedwithanti-VEGFmonotherapy.Furthermore,combinedtherapydoesnotincreasetheincidenceofretinalhemorrhage.

简介：EuphorbiakansuiisacommonlyusedtraditionalChinesemedicineforthetreatmentofedema,pleuraleffusion,andasthma,etc.Accordingtothepreviousresearches,terpenoidsinE.kansuipossessvariousbiologicalactivities,e.g.,anti-virus,anti-allergy,antitumoreffects.Inthiswork,twentyfiveterpenoidswereisolatedfromE.kansui,includingthirteeningenane-andeightjatrophane-typediterpenoids(withtwonewcompounds,kansuininPandQ)andfourtriterpenoids.EighteenofthemwereanalyzedbyMTSassayforinvitroanticanceractivityinfivehumancancercelllines.Structure-activityrelationshipfor12ingenane-typediterpenoidsincolorectalcancerColo205cellswerepreliminarystudied.Significantanti-proliferationactivitieswereobservedinhumanmelanomacellsbreastcancerMDA-MB-435cellsandColo205cells.Morethanhalfoftheisolatedingenane-typediterpenoidsshowedinhibitoryactivitiesinMDA-MB-435cells.Eightingenane-andonejatrophane-typediterpenoidspossessedmuchlowerIC_(50)valuesinMDA-MB-435cellsthanpositivecontrolstaurosporine.Preliminarystructure-activityrelationshipanalysisshowedthatsubstituentonposition20wasimportantfortheactivityofingenane-typediterpenoidsinColo205cellsandsubstituentonposition3contributedmoresignificantbiologicalactivityofthecompoundsthanthatonposition5inbothMDA-MB-435andColo205cells.

简介：Thepresentstudywasdesignedtoinvestigatetheanti-sepsiseffectsofphyscion8-O-β-glucopyranoside(POG)isolatedfromRumexjaponicasandexploreitspossiblepharmacologicalmechanisms.POGwasextractedfromR.japonicasbybioactivity-guidedisolationwiththeanti-sepsisagents.SurvivalanalysisinsepticmouseinducedbyLPSandheat-killedEscherichiacoliwereusedtoevaluatetheprotectiveeffectofPOG(40mg·kg~(-1),i.p.)onsepsis.CytokinesincludingTNF-α,IL-1βandIL-6inRAW264.7cellsinducedbyLPS(100ng·mL~(-1))weredeterminedbyELISA.Inaddition,theproteinsexpressionsofTLR2andTLR4weredeterminedbyWesternblottingassay.OurresultsdemonstratedthatPOG(40mg·kg~(-1),i.p.)possessedsignificantprotectiveactivityontheendotoxemicmice.ThePOGtreatment(20,40,and80μg·mL~(-1))significantlydecreasedtheTNF-α,IL-1βandIL-6inducedbyLPS(P<0.01)inaconcentration-dependentmanner.Furthermore,theTLR4andTLR2proteinswerealsodown-regulatedbyPOGat20(P<0.01),40(P<0.01),and80μg·mL~(-1)(P<0.01).ThepresentstudydemonstratedthatthePOGextractedfromR.japonicaspossessedsignificantanti-sepsiseffectonendotoxemicmice,andcanbedevelopedasanoveldrugfortreatingsepsisinthefuture.

简介：AIMTo在cells.METHODSARPE-19细胞是的网膜的颜料上皮(RPE)上调查高葡萄糖层次和反脉管的endothelial生长因素(VEGF)代理人(bevacizumab，ranibizumab和aflibercept)的效果在不同葡萄糖层次(5.5mmol/L，25mmol/L，和75mmol/L)有教养。房间生存能力被MTT试金与D葡萄糖在处理以后在3d评估。房间迁居能力被创伤愈合试金在3d测量。一个房间死亡察觉工具包被用来在3点估计apoptosis并且14d。房间增长被EdU试金在3d估计。文化媒介在临床上相关的集中与anti-VEGF代理人被对待。实验然后在一个不同葡萄糖level.RESULTSThe生存能力被重复，ARPE-19房间的移植显著地作为与5.5mmol/L葡萄糖相比面对75mmol/L被减少。TUNEL积极的房间的百分比显著地被增加，proliferative潜力与5.5mmol/L葡萄糖相比与75mmol/L被减少。在在25mmol/L和5.5mmol/L葡萄糖之间的结果没有重要差别。面对75mmol/L葡萄糖，与anti-VEGF对待的组显示出减少的房间生存能力和增长并且增加了apoptosis。然而，anti-VEGFgroups.CONCLUSIONHigh葡萄糖水平减少之间没有重要差别RPE房间的生存能力，创伤愈合能力，和增长，当增加apoptosis时。而且，anti-VEGF代理人在高葡萄糖的条件下面防碍RPE房间的生理的功能，在房间生存能力和增长由减少伴随了。

简介：流行性感冒病毒红血球凝聚素的梗区域很好相对与球状的头领域相比被保存，它对流行性感冒用作一支通用疫苗使它成为一个潜在的目标。然而，在红血球凝聚素的CD4T房间的角色梗特定的有免疫力的反应不是清楚的。这里，我们识别了在流行性感冒的尚不致命的感染以后从红血球凝聚素梗领域包含残余HA2113-131的老鼠CD4T房间epitope。响应有识别epitope的刺激，从感染的老鼠导出的splenocytes显示出象degranulation一样由IL-2，TNF-和IFN-生产出现的重要polyfunctionality。而且，与相应于这CD4T房间epitope的肽使免疫的老鼠展出了CD4T房间受体分享的interindividual序列，和他们有更高的幸存率与流行H1N1流行性感冒的致命的剂量跟随挑战病毒。因此，我们的数据表明了红血球凝聚素的一个关键角色在对流行性感冒病毒感染的主机免疫者反应的梗特定的CD4T房间。

简介：ThefruitsofPaulowniacatalpifoliaGongTongareusedasaChinesefolkherbalmedicineforthetreatmentofenteritis,tonsillitis,bronchitis,anddysentery,etc.OurpreviousstudyhasidentifiednewC-geranylatedflavanoneswithobviousanti-proliferativeeffectsinlungcancerA549cells.Inthepresentstudy,anewC-geranylatedflavone,paucatalinoneC(1)andfiveknownC-geranylatedflavanones(2-6)wereisolated.Inaddition,atotalof34C-geranylatedflavonoidsweredetectedbyHPLC-DAD-ESI-MS/MScouplingtechniquesfromtheCH_2Cl_2extractofP.catalpifolia.Futhermore,anti-agingeffectsofisolatedcompoundswereevaluatedinvitrowithprematuresenescent2BScellsinducedbyH_2O_2.PhytochemicalresultsindicatedthatP.catalpifoliawasanaturalresourceofabundantC-geranylatedflavonoids.Diplacone(3)andpaucatalinoneA(5)werethepotentanti-agingagentsintheprematuresenescent2BScellsinducedbyH_2O_2andtheC-geranylsubstituentmaybeanimportantfactorbecauseofitslipophiliccharacter.