简介:AbstractHepatitis D virus (HDV) infection causes the most severe form of viral hepatitis with rapid progression to cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Although discovered > 40 years ago, little attention has been paid to this pathogen from both scientific and public communities. However, effectively combating hepatitis D requires advanced scientific knowledge and joint efforts from multi-stakeholders. In this review, we emphasized the recent advances in HDV virology, epidemiology, clinical feature, treatment, and prevention. We not only highlighted the remaining challenges but also the opportunities that can move the field forward.
简介:摘要:近年随着中国自主研制的核电机组在海外成功并网发电,预示着我国拥有了自主核电出口技术,在核电站建设过程中,核岛关键设备质量控制要求高,对核电建安工期的关键路径,尤其是海外核电机组,除受建安因素的影响,还受制于国际运输。国内核电环吊的吊装引入是通过地面预组装后,通过大吊车将分段吊装就位后在空中进行整体组装。主设备的安装前的引入就位主要是靠核岛龙门架的重型吊车、主设备运输小车及反应堆厂房环形吊车配合完成设备引入及安装全部的工艺过程。但在海外核电关键设备安装过程中,由于受海外不利因素影响,致使关键设备引入及安装对整个建安工期影响尤为突出。为保证主工期目标按期完成,尽量避免不利因素对工期延误的影响。海外某核电项目经分析和论证,决定采用环吊整体吊装和主设备预引入技术。
简介:摘要:在这个社会的不断发展中,经济环境不断转变,大家的生活品质大大提高,与此同时,大家的观念也产生了很大的变化,慢慢的意识到了生态文明建设的必要性,在时代的发展要求影响下,水工环的必要性获得了充足的一种体现,已经成了现阶段的关键点具体内容。在过去一些年里,在我国尽管在经济领域成绩显著,可是绿色生态品质却一落千丈,因此,必须持续推进水工环地质剖析,完成对网络资源高效利用,那也是现阶段的社会认知每日任务。文中对此进行分析,而且明确提出了几点浅见。
简介:【摘要】建国之后,在党的带领下我国大力开展经济建设,科学技术建设,农业建设等,时至今日我国的经济水平快速稳定增长,工业生产、科学技术不断发展壮大,使得人们的生活质量发生了翻天覆地的变化,但与此同时我们生活的环境也发生了巨大的改变,衍生出了环境污染问题,部分地区环境污染严重已经影响到人们的生产生活。众多行业多是以发展经济现设为主,因此对于环境的保护意识相对不足,因此在生产生活中无形的就出现了污染环境的行为,导致我们生存所必需的水资源、空气、地理环境受到影响,从长远分析,只顾经济发展而忽视环境保护必然导致人类面临巨大的灾难,最终阻碍人类生存发展。因此越来越多的人开始关注环境问题,其中水工环地质问题引起了众多学者的关注,基于此,本次探究就针对水工环现状进行分析,提出有效的突破方法。
简介:AbstractBackground:The complete mesogastrium excision (CME) based on D2 radical gastrectomy is believed to significantly reduce the local-regional recurrence compared with D2 radical gastrectomy in advanced gastric cancer, and it is widely used in China. This study aimed to explore whether D2 + CME is superior to D2 on surgical outcomes during gastrectomy from Chinese data.Methods:Feasible studies comparing the D2 + CME (D2 + CME group) and D2 (D2 group) published up to March 2020 are searched from electronic databases. The data showing surgical and complication outcomes are extracted to be pooled and analyzed.Results:Fourteen records including 1352 patients were included. The D2 + CME group had a shorter mean operative time (weighted mean difference [WMD] = -16.72 min, 95% confidence interval [CI]: -26.56 to - 6.87 min, P < 0.001), lower mean blood loss (WMD = -39.08 mL, 95% CI: -49.94 to -28.21 mL, P < 0.001), higher mean number of retrieved lymph nodes (WMD = 2.13, 95% CI: 0.58-3.67, P = 0.007), shorter time to first flatus (WMD =-0.31 d, 95% CI: -0.53 to - 0.10 d, P = 0.005), and postoperative hospital days (WMD =-1.09, 95% CI: -1.92 to -0.25, P = 0.010) than the D2 group. Subgroup analysis suggested that the advantages from the D2 + CME group were obvious in traditional open radical gastrectomy, proximal gastrectomy, and distal gastrectomy compared with D2 group. The evaluations of post-operative complications showed that the patients who underwent D2 + CME had a lower incidence of post-operative complications than the patients who underwent D2 surgery alone (relative risk [RR] = 0.65, 95% CI: 0.45-0.87, P = 0.003). The D2 radical gastrectomy plus CME improved 3-year overall survival (OS) (RR = 1.16, 95% CI: 1.02-1.32, P = 0.020) and lowered the local recurrence rate (RR = 0.51, 95% CI: 0.28-0.94, P = 0.030). The patients undergoing laparoscopic surgery or total gastrectomy had more significant advantages compared between D2 + CME and D2 groups in 3-year OS.Conclusion:The data from China show that D2 radical gastrectomy plus CME are reliable procedures and safety compared to D2 radical gastrectomy with faster recovery, lower risk, and better prognosis.
简介:摘要目的探讨多囊卵巢综合征(PCOS)不孕症患者应用维生素D、二甲双胍、炔雌醇环丙孕酮联合治疗的临床疗效。方法抽取2018年6月至2020年6月临沂市中医院收治的110例PCOS不孕症患者为研究对象,参照随机数字表法分为观察组和对照组,每组55例。对照组采用二甲双胍、炔雌醇环丙孕酮联合治疗,观察组采用维生素D联合二甲双胍及炔雌醇环丙孕酮治疗。两组均随访1年以上,比较两组疗效、随访1年时月经恢复/排卵/妊娠情况,以及治疗前后内分泌相关激素、维生素D水平及胰岛素抵抗率。结果观察组总有效率(96.36%,53/55)高于对照组(80.00%,44/55),且随访1年时月经恢复率、排卵率及妊娠率(96.36%,53/55;90.91%,50/55;69.09%,38/55)均高于对照组(72.73%,40/55;60.00%,33/55;47.27%,26/55),P均<0.05。治疗前,两组内分泌相关激素水平、维生素D及胰岛素抵抗率比较差异未见统计学意义(P>0.05);治疗后,观察组黄体生成素、睾酮、黄体生成素/促卵泡激素、抗苗勒管激素水平及胰岛素抵抗率均低于对照组,而维生素D水平高于对照组,差异有统计学意义(P<0.05)。结论PCOS不孕症患者应用维生素D、二甲双胍、炔雌醇环丙孕酮联合治疗可进一步提高临床疗效,改善内分泌相关激素及维生素D水平,降低胰岛素抵抗率,提高月经恢复率、排卵率及妊娠率。
简介:【摘要】目的 分析在对深静脉血栓形成患者进行早期诊断的过程中,D二聚体(D-D)与凝血因子联合检测的效果。方法 本次研究于本院随机抽取了31例2020年3月-2021年3月接诊的早期深静脉血栓形成患者设为研究组,另选同时期接收的健康体检患者31例设为参照组。两组患者均接受D二聚体与凝血因子联合检测,对比患者的检测结果。结果 研究组接受检测后患者D二聚体指标更高,凝血因子指标更低,对比差异明显(P<0.05)。 结论 在进行早期深静脉血栓形成患者的诊断过程中,D二聚体联合凝血因子的检测能够充分显示患者在其的血浆指标变化,对深静脉血栓的形成进行提示,以便尽早采取有效的措施进行干预,适合于临床中应用。