简介：1920sAmericaembracedanageofprosperityandliberation.Economysoaredthatraisedpeople'slivingstandard.Peoplelearnprogressiveideas,andsocietybecomemoredemocratic.

简介：ObjectiveThenearlyparallelN–S-trendingriftsinsouthernTibetrepresenttheE–WextensionoftheTibetPlateau.MostdatawhichconstrainedtheageoftheextensionaldeformationcomefromisotopicdatingofthedikesprobablyrelatedtotheactivityofthenearlyN–Sfaultingandmicasfromhydrothermalactivityandthelowtemperaturethermochronologyofplateauuplift.Previous

简介：

简介：从Lombok岛，印度尼西亚，和包围区域的paleotsunami沉积的年龄决心用210在BATAN雅加达的Pb方法。包括paleotsunami沉积，方法假定那捱过沉积的这的基本理论将导致210Pb丰富。这个方法的原则是计算210在到更深埋葬的沉积的从表面的特别沉积间隔的Pb内容累积。结果然后在以前联合起来的年里被变换成年龄或depositional时间。从GawahPudak的paleotsunami沉积的标明日期的结果(S8?？？

简介：Age-relatedmaculardegeneration(AMD)causesirreversiblelossofcentralvisionforwhichthereisnoeffectivetreatment.IncipientpathologyisthoughttooccurintheretinaformanyyearsbeforeAMDmanifestsfrommidlifeonwardstoaffectalargeproportionoftheelderly.Althoughgeneticaswellasnon-genetic/environmentalrisksarerecognized,itscomplexaetiologymakesitdifficulttoidentifysusceptibility,orindeedwhattypeofAMDdevelopsorhowquicklyitprogressesindifferentindividuals.HerewesummarizetheliteraturedescribinghowtheAlzheimer's-linkedamyloidbeta(Aβ)groupofmisfoldingproteinsaccumulateintheretina.ThediscoveryofthiskeydriverofAlzheimer'sdiseaseinthesenescentretinawasunexpectedandsurprising,enablinganaltogetherdifferentperspectiveofAMD.WearguethatAβfundamentallydiffersfromothersubstanceswhichaccumulateintheageingretina,anddiscussourlatestfindingsfromamousemodelinwhichphysiologicalamountsofAβweresubretinally-injectedtorecapitulatesalientfeaturesofearlyAMDwithinashortperiod.OurdiscoveriesaswellasthoseofotherssuggestthepatternofAβaccumulationandpathologyindonoraged/AMDtissuesarecloselyreproducedinmice,includinglate-stageAMDphenotypes,whichmakesthemhighlyattractivetostudydynamicaspectsofAβ-mediatedretinopathy.Furthermore,wediscussourfindingsrevealinghowAβbehavesatsingle-cellresolution,andconsiderthelong-termimplicationsforneuroretinalfunction.WeproposeAβasakeyelementinswitchingtoadiseasedretinalphenotype,whichisnowbeingusedasabiomarkerforlatestageAMD.

简介：UnlikeIndo-Europeanlanguages,Mandarinreliesheavilyonlexicaltonestodistinguishwordidentity.Usingtheintermodalpreferentiallookingparadigm,thisstudyexamined3-year-oldMandarinspeakers'abilitytouseMandarinlexicaltonesinlearningnewwords.ResultsshowedthatwhenchildrenwerepresentedwithTone2(rising)andTone4(falling)pairs,childrensuccessfullylearnedbothwords.However,whenchildrenwerepresentedwithTone2andTone3(dipping)pairs,theylearnedtheTone2wordbutnottheTone3one.ChildrenwerethendividedintotwogroupsbasedontheirlearningperformanceontheTone3word.SuccessfullearningofTone3wordswasobservedinthehighperformersbutnotinthelowperformers,whoconsistentlymisusedTone3asTone2.ThisstudyshowedthatMandarinspeaking3-year-oldscoulduselexicaltonestolearnwordsunderexperimentalconditions,andthatthedifficultyofTone3acquisitionmayberelatedtoitslowerlevelofperceptualdistinctivenesscomparedwithothertones.

简介：BackgroundDesigning在孩子和少年的年龄评价的一条简单、可存取的途径是运动和物理活动(PA)的领域里的大挑战。这研究被设计开发并且验证在代表性的研究在2014进行了的年轻children.MethodsIn估计年龄的一个physical-examination-based方法，我们执行了物理考试并且在上海在14,970小学孩子7-12岁之中估计了PA，中国。孩子们高度和出生日期的另外的生物信息通过他们的父母被查明。二指示物被使用开发一个性特定的年龄评价方程：预言的成熟高度(PPMH)和更黝黑的阶段的百分比。方程通过一条k褶层交叉验证途径被验证。到为评价精确性的支票，在估计的年龄(EA)和按年代先后的年龄和PA的差异之间的协会是EA的性特定的方程如下是的examined.ResultsThe：EA男孩=-6.071+6.559更黝黑的2+13.315更黝黑的3+14.130更黝黑的4+0.190PPMH-0.071更黝黑2

简介：为neovascular在诊断和预后调查neutrophil-to-lymphocyte比率(NLR)和platelet-to-lymphocyte比率(PLR)的地方年龄相关的有斑点的退化(AMD).METHODSOne百个AMD病人和100健康控制在学习被包括。血样品从静脉的血被获得，它被用于平淡的分析，并且这些样品被使遭到完成血计数。NLR被定义为淋巴细胞的数字划分的嗜中性的计数，并且PLR被定义为lymphocytes.RESULTSNo的数字划分的血小板计数统计上重要的差别以人口统计的特征在考虑下面在二个组之间被观察(P>0.05)。在耐心的组的平均NLR被发现在健康控制组比那显著地高(P<0.05)。平均PLR作为与控制组相比在耐心的组是显著地更高的(P<0.05)。当最好改正的视觉尖酸(BCVA)增加了，NLR和PLR减少了(在49.8%和63.0%点的重要否定关联，分别地)而当中央有斑点的厚度(CMT)增加了，NLR和PLR增加了(在59.3%和70.0%点的重要积极关联，分别地).CONCLUSIONNLR和PLR层次作为与健康控制相比在neovascularAMD病人之中是更高的组。NLR和PLR层次被发现与BCVA并且直接相反地成正比与CMT成正比。

简介：Purpose:Theprimaryaimofthisstudywastodevelopanassessmentofthefundamental,combined,andcomplexmovementskillsrequiredtosupportchildhoodphysicalliteracy.Thesecondaryaimwastoestablishthefeasibility,objectivity,andreliabilityevidencefortheassessment.Methods:Anexpertadvisorygrouprecommendedacourseformatfortheassessmentthatwouldrequirechildrentocompleteaseriesofdynamicmovementskills.Criterion-referencedskillperformanceandcompletiontimeweretherecommendedformsofevaluation.Children,8–12yearsofage,self-reportedtheirageandgenderandthencompletedthestudyassessmentswhileattendinglocalschoolsordaycamps.FacevaliditywaspreviouslyestablishedthroughaDelphiexpert(n=19,21%female)reviewprocess.Convergentvaliditywasevaluatedbyageandgenderassociationswithassessmentperformance.Inter-andintra-rater(n=53,34%female)objectivityandtest–retest(n=60,47%female)reliabilitywereassessedthroughrepeatedtestadministration.Results:Mediantotalscorewas21of28points(range5–28).Mediancompletiontimewas17s.Totalscoreswerefeasibleforall995childrenwhoself-reportedageandgender.Totalscoredidnotdifferbetweeninsideandoutsideenvironments(95%confidenceinterval(CI)ofdifference:-0.7to0.6;p=0.91)orwith/withoutfootwear(95%CIofdifference:-2.5to1.9;p=0.77).Olderage(p<0.001,η2=0.15)andmalegender(p<0.001,η2=0.02)wereassociatedwithahighertotalscore.Inter-raterobjectivityevidencewasexcellent(intraclasscorrelationcoefficient(ICC)=0.99)forcompletiontimeandsubstantialforskillscore(ICC=0.69)for104attemptsby53children(34%female).Intra-raterobjectivitywasmoderate(ICC=0.52)forskillscoreandexcellentforcompletiontime(ICC=0.99).Reliabilitywasexcellentforcompletiontimeoverashort(2–4days;ICC=0.84)orlong(8–14days;ICC=0.82)interval.Skillscorereliabilitywasmoderate(ICC=0.46)overashortinterval,a

简介：Defenceproteinsareakindofchemicaldefencecompounds.Theyplayakeyroleinplantrestrainingbioticandabioticharm.Toilluminateactivitiesofsomedefenseproteinsassociatedwithageorplantfamilyoflarch,thelarchneedleswerecollectedfromtwodifferentfamiliesofKoreanlarch,Larixolgensisandahybridlarch,L.kaempferi×L.gmelinii,respectively,andthentheactivitiesofdefenceproteinsinthoseweretestedusingaUVspectrophotometry.Theresultsshowedthattheactivitiesofprotectiveenzymesatthe16-/17-and19-year-agegroupswerehigherthanthoseattheotheragegroupsinthebothlarchspecies.Whiletheactivitiesofpolyphenoloxidase(PPO)atthe16-/17-year-agegroupandphenylalanineammonia-lyase(PAL)andproteaseinhibitorsatthe19-year-agegroupwerethehighestamongallagegroups.Then,comparedwithL.olgensis,thehybridlarchhadsignificanteffectsontheactivitiesofprotectiveenzymes.TheeffectsofplantfamilyontheactivitiesofPALandchymotrypsininhibitorweresignificantlydifferent,andthenthoseontheactivitiesofPPOwerenotsignificantlydifferent.TheeffectsofthetwofamiliesinL.olgensisontheactivitiesoftrypsininhibitor(TI)weresignificantlydifferent,whilethoseinthehybridlarchontheactivitiesofTIwerecontrary.Toconclusionsshowedthatthedifferentageandplantfamilysignificantlyaffectedtheactivitiesofdefenceproteinsintheneedlesoftwolarchspecies,andthenenhancedthelarchresistancetopests.Thesecouldplayakeyfunctioninforestrytreegeneticimprovementandmanagementinfuture.

简介：

简介：