简介：AbstractThe novel betacoronavirus (Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2) is a pathogen that causes deadly respiratory disease named coronavirus disease 2019 (COVID-19). The incidence of this disease has increased in the last few months affecting 257,832,881 people in 221 countries and 51,68,069 deaths worldwide according to Worldometer at 04:03 GMT on November 22, 2021. Thus, the emergence of this disease creates a challenge for health care providers in handling this pathogen and reducing its risk of transmission. In developing countries, this virus is treated in biosafety level 2 laboratories, where a high concentration of pathogen can easily affect the laboratory staff and cause the spread of this disease. Based on the epidemiology and characteristics of the SARS-CoV-2 virus already discussed in recent studies, we will provide biosafety guidelines and suggestions for safe handling and transportation of the SARS-CoV-2 virus in dealing with the current pandemic situation with a focus on increased infectivity of emerging new variants.

简介：Objective:Toinvestigatetheuptakerateofprostatespecificantigen(PSA)testingamongHongKongChinesemalesaged50orabove,andidentifyfactorsassociatedwiththelikelihoodofundergoingaPSAtest.Methods:Apopulation-basedtelephonesurveywasconductedinHongKongin2007.Thesurveycovereddemographicinformation,perceivedhealthstatus,useofcomplementarytherapy,cancerscreeningbehavior,perceivedsusceptibilitytocancerandfamilyhistoryofcancer.Descriptivestatistics,percentagesandlogisticregressionanalysiswereusedfordataanalysis.Results:Atotalof1,002menaged50orabovetookpartinthestudy(responserate=67%),andtheuptakerateofPSAtestingwasfoundtobe10%.Employmentstatus,useofcomplementarytherapy,perceivingregularvisitstoadoctorasgoodforhealthandtherecommendationsofhealthprofessionalsweresignificantfactorsassociatedwithPSAtesting.Conclusion:TheuptakerateofPSAtestinginthestudypopulationwasverylow.Amongallthefactorsidentified,recommendationsfromhealthprofessionalshadthestrongestassociationwiththeuptakeofPSAtesting,andtheyshouldthereforetakeanactiveroleineducatingthispopulationaboutcancerpreventionanddetection.

简介：＂翻转课堂＂即转变传统的教师统一授课,学生课后复习提高的教学结构,通过对教学模式的颠倒安排,课前有效监管和指导在线听说学习结合课上有目的小班面授,实现课程真正地个性化教学。TMM课程体系的混元英语教学模式是大学英语听说课程改革的新模式,而TMM教学体系下大学英语听说课程评估的实施是成功实施此模式的关键。该研究通过TellMeMore课程口语评估体系的建立,分析其对学生以语言智能为主的多种学习智能发展的影响,为高等院校大学英语听说教学改革拓展了一个崭新的思路。

简介：AlargescalehumanrightsexhibitionwasheldinsidetheMuseumofCulturePalaceoftheNationalitiesindowntownBeijing,Novem-ber17-26.2006mainlyshowcasingthecountry'seffortsandprogressithasmadeandismakinginhumanrightsprotectionandpromotioninChinasincethefounda-tionofnewChinain1949.

简介：39Vibriocholerae的一个总数非，非，O139拉紧的O1从Dhaka城市的不同部分的表面水被孤立，孟加拉国。，显示出的这些种类ctx或zot基因缺乏的所有由PCRanalysis.Eighteen代表证明种类为enterotoxin生产使用被测试一个兔子ileal环模型，哪个生活8个种类和文化的房间6个种类过滤在ileal的生产液体累积循环。然而，任何一个都没他们生产热马厩毒素(圣)，由乳臭未干的老鼠试金检测了。在另一方面，中的15%个孤立由中国仓鼠卵巢(CHO)房间试金检测了的生产细胞毒素。乘集中的文化的五十紧张没对反霍乱毒素给任何沉淀素乐队的代表过滤，建议紧张生产了enterotoxin，它与已知的霍乱毒素(CT)antigenically不同。百分之八十个总数孤立被发现为易变的haemolysin由试管方法检测了的热积极，而，39%被Christie-Atkins-Munch-Petersen(营地)方法发现积极。然而，87%isolates是积极的因为紧张的haemagglutinin/protease和所有为mannose-sensitive-haemagglutinin试金是积极的。

简介：Duringthelastdecade,wehaveseentremendousprogressinthetherapyoflungcancer.DiscoveryofactionablemutationsinEGFRandtranslocationsinALKandROS1haveidentifiedsubsetsofpatientswithexcellenttumorresponsetooraltargetedagentswithmanageablesideeffects.Inthisreview,wehighlighttreatmentoptionsincludingcorrespondingclinicaltrialsforoncogenicalterationsaffectingthereceptortyrosinekinasesMET,FGFR,NTRK,RET,HER2,HER3,andHER4aswellascomponentsoftheRAS-RAF-MEKsignalingpathway.

简介：InthesecondyearofKaihuang开皇reign(AD582),SuiDynastyEmperorWendi文帝issuedthedecreeofconstructinganewcapital,whichwascalledDaxing大兴.AfterthefoundingoftheTangDynastyinthefirstyearofWude武德,reign(618),thiscityremainedthecapitalbutwasrenamedChang'an.

简介：MALTA,apicturesqueislandnationinthesouthofEurope,isdubbedasthe“heartoftheMediterranean.”GeographicallyconnectingEurope,Asia,andAfrica,Malta,anEUmembercountry,isaneconomicallywell-developedcountrywithitspercapitaGDPin2017reachingUS$27,145.81,considerablyhigherthantheworld’saverage.MaltaestablisheddiplomaticrelationswithChinaonJanuary31,1972–oneofthefirstWesterncountriestodoso.Sincethen.

简介：SophoraeFlavescentisRadix(SophoraflavescensAit.,SFR)andSophoraeTonkinensisRadixetRhizoma(S.tonkinensisGapnep.,STR)aretwocommonlyusedtraditionalChinesemedicinesfromSophora(Leguminosae)plants,whicharebelievedtopossesssimilarbioactivecomponentswithentirelydifferentclinicalapplications.InordertofindoutthecharacteristicchemicalconstituentspotentiallyleadingtotheuniquemedicinalpropertiesclaimedforeachofthetwocloselyrelatedTCMs,anHPLCfingerprintmethodwasdevelopedforanalysesofthealkaloidandflavonoidconstituentsofSFRandSTR,respectively,whichwerefurtherevaluatedandcomparedthroughsimilaritycalculationandhierarchicalclusteringanalysis(HCA).Theresultsfromthepresentstudyshowedthatthealkaloidfingerprintsofthetwoherbsweresimilar,withmanycomponentsco-existinginbothdrugsandvariousbatchesofsamplesfromdifferentspeciesbeingmixedtogetherintheHCAdendrogram.However,theirflavonoidconstituentsweretotallydifferentwithspecificfingerprintsbeingyieldedforeachherb,andfurtherHCAanalysisshowedthatthetestedsamplescouldalmostbeclearlydividedintotwogroupsbasedontheiroriginsofspecies.TheresultsfromthepresentstudyindicatedthattheflavonoidconstituentscouldserveasthedifferentiallydiagnosticconstituentsofSFRandSTRandmightpotentiallyattributedtotheirdistincttherapeuticeffects.

简介：<正>Theauthorregrets〈Thecorrectedtitleshouldbe"Peoplecanlivelongerbyhavingmorephysicalactivity"〉.

简介：AbstractBackground:Whether smoking is related to a decreased risk of meningioma in women is still controversial. We conducted a systematic review and meta-analysis examining the association between smoking and risk of meningiomas in women.Methods:Two authors independently performed a systematic literature review in the PubMed, Cochrane Library, and EMBASE databases. We identified case-control and cohort studies quantifying associations between smoking and risk of meningioma in women. A meta-analysis by pooling studies was performed according to the multivariate-adjusted risk estimates and 95% confidence intervals (CIs) preferentially. We further conducted additional subgroup and sensitivity analyses to explore possible explanations of the results.Results:A total of seven observational studies were included, with a total of 2132 female patients diagnosed with meningiomas. Ever smoking was associated with a significantly reduced risk of meningioma in women, with pooled odds ratio (OR) of 0.83 (95% CI 0.70-0.98). Similar findings were noted for current (OR 0.78, 95% CI 0.66-0.93) and past (OR 0.82, 95% CI 0.71-0.94) smokers. However, considering the areas, the OR of ever smoking was 0.77 (95% CI 0.68-0.87) in three American studies, but 0.99 (95% CI 0.73-1.35) in four studies conducted in other countries.Conclusions:Based on limited epidemiological evidence, a decreased risk of meningioma in women smokers was only observed in American studies rather than studies conducted in other countries.

简介：BackgroundCentralaorticsystolicbloodpressure(CASP)hasbeenshowntobeastrongerpredictoroftarget-organdamageandcardiovasculareventsthanbrachialsystolicbloodpressure(BSBP),buttherewasnodataaboutwhetherCASPcanpredictprolongedQRSdurationmorethanBSBP.WeexaminedtheassociationofCASPandBSBPwithQRSdurationinruralcommunityresidents.MethodsWeretrospectivelyanalyzed490ruralcommunityresidents.Standardresting12-leadECGandcentralaorticbloodpressure(CABP)weremeasurednoninvasivelyinallsubjectsatbaseline.TheQRSdurationwasequaltoormorethan120msbeingdefinedasprolongedQRSduration.ResultsTheprolongedQRSdurationgroupshowedhigherCASP(139.38±11.67vs.135.36±16.22,P=0.031)andBSBP(136.03±6.74vs.124.44±13.01,P<0.001)ascomparedwithcontrols.MultivariatelinearregressionanalysisshowedthatCASP,BSBPandheartratewereindependentlyaffectingQRSduration.LogisticregressionanalysesshowedthatCASP(OR1.057,95%CI:1.027,1.088,P<0.001)andBSBP(OR1.056,95%CI:1.027,1.086,P=0.032)wereindependentpredictorsofprolongedQRSdurationafteradjustmentforage,sex,bodymassindex,heartrate.CASPhadabetterpredictivevalueforprolongedQRSdurationthan(AUC:0.793vs.0.601,P<0.001)BSBP.ConclusionsOurfindingsdemonstratethatbothCASPandBSBParerisksforprolongedQRSduration,butCASPcanpredictprolongedQRSdurationbetterthanBSBP.

简介：

简介：AbstractBackground:Although the use of expanded-criteria donors (ECDs) alleviates the problem of organ shortage, it significantly increases the incidence of delayed graft function (DGF). DGF is a common complication after kidney transplantation; however, the effect of DGF on graft loss is uncertain based on the published literature. Hence, the aim of this study was to determine the relationship between DGF and allograft survival.Methods:We conducted a retrospective, multicenter, observation cohort study. A total of 284 deceased donors and 541 recipients between February 2012 and March 2017 were included. We used logistic regression analysis to verify the association between clinical parameters and DGF, and Cox proportional hazards models were applied to quantify the hazard ratios of DGF for kidney graft loss.Results:Among the 284 deceased donors, 65 (22.8%) donors were ECD. Of the 541 recipients, 107 (19.8%) recipients developed DGF, and this rate was higher with ECD kidneys than with standard-criteria donor (SCD) kidneys (29.2% vs. 17.1%; P = 0.003). The 5-year graft survival rate was not significantly different between SCD kidney recipients with and without DGF (95.8% vs. 95.4%; P= 0.580). However, there was a significant difference between ECD kidney recipients with and without DGF (71.4% vs. 97.6%; P = 0.001), and the adjusted hazard ratio (HR) for graft loss for recipients with DGF was 1.885 (95% confidence interval [CI] = 1.305–7.630; P = 0.024). Results showed that induction therapy with anti-thymocyte globulin was protective against DGF (odds ratio= 0.359; 95% CI= 0.197–0.652; P= 0.001) with all donor kidneys and a protective factor for graft survival (HR = 0.308; 95% CI = 0.130–0.728; P = 0.007) with ECD kidneys.Conclusion:DGF is an independent risk factor for graft survival in recipients with ECD kidneys, but not SCD kidneys.

简介：Si16Sb84-based线房间阶段变化随机存取记忆(PCRAM)，在哪个Si16Sb84阶段变化线被听电极与nanoscale差距联系，被为重设操作的最低当前、测量的脉搏宽度是的电子横梁平版印刷术制作115μA和18ns，分别地为再结晶的测量最短的脉搏宽度是110ns，与1.5V的应用脉搏振幅。为有不同的线长度的线房间的集合和重设电流是坚定的。106的耐力与上面的电阻比率骑车800被完成了。

简介：12月10日．位于上海宝山区的美兰湖皇冠假日酒店内人潮涌动，来自全国各地的100多位顶级网球经销商齐聚一堂．竞相目睹2012Wilson最新网球系列产品的风貌。

简介：MoreFrequentFlyerBenefit——AirChinaandShanhaiAirlinesJoinStarAllianceIntheendof2007,AirChinaLimited(hereinafter'AirChina')andShang-haiAirlines,formallyjoinedStarAlli-anceataceremonyheldinthenewTermi-nalThreeatBeijingCapitalInternationalAirport.WiththeadditionofthetwoChineseairlines,StarAlliancenowhas19membercarriersoperating17,000dailyflightsto897destinationsin160countries.

简介：AbstractBackground:Compared with human leukocyte antigen (HLA)-matched sibling donor (MSD) transplantation, it remains unclear whether haploidentical donor (HID) transplantation has a superior graft-versus-leukemia (GVL) effect for Philadelphia-negative (Ph-) high-risk B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to compare the GVL effect between HID and MSD transplantation for Ph- high-risk B-ALL.Methods:This study population came from two prospective multicenter trials (NCT01883180, NCT02673008). Immunosuppressant withdrawal and prophylactic or pre-emptive donor lymphocyte infusion (DLI) were administered in patients without active graft-versus-host disease (GVHD) to prevent relapse. All patients with measurable residual disease (MRD) positivity posttransplantation (post-MRD+) or non-remission (NR) pre-transplantation received prophylactic/pre-emptive interventions. The primary endpoint was the incidence of post-MRD+.Results:A total of 335 patients with Ph- high-risk B-ALL were enrolled, including 145 and 190, respectively, in the HID and MSD groups. The 3-year cumulative incidence of post-MRD+ was 27.2% (95% confidence interval [CI]: 20.2%-34.7%) and 42.6% (35.5%-49.6%) in the HID and MSD groups (P = 0.003), respectively. A total of 156 patients received DLI, including 60 (41.4%) and 96 (50.5%), respectively, in the HID and MSD groups (P= 0.096). The 3-year cumulative incidence of relapse was 18.6% (95% CI: 12.7%-25.4%) and 25.9% (19.9%-32.3%; P = 0.116) in the two groups, respectively. The 3-year overall survival (OS) was 67.4% (95% CI: 59.1%-74.4%) and 61.6% (54.2%-68.1%; P = 0.382), leukemia-free survival (LFS) was 63.4% (95% CI: 55.0%-70.7%) and 58.2% (50.8%-64.9%; P= 0.429), and GVHD-free/relapse-free survival (GRFS) was 51.7% (95% CI: 43.3%-59.5%) and 37.8% (30.9%-44.6%; P= 0.041), respectively, in the HID and MSD groups.Conclusion:HID transplantation has a lower incidence of post-MRD+ than MSD transplantation, suggesting that HID transplantation might have a superior GVL effect than MSD transplantation for Ph- high-risk B-ALL patients.Trial registration:ClinicalTrials.gov: NCT01883180, NCT02673008.

简介：【摘要】《义务教育英语标准》（2011版）明确规定了英语教学的主要目标是为了培养学生的英语核心素养，英语学习活动观是落实英语核心素养的重要途径。本文以英语学习活动观为指导，通过粤教版《开心学英语》六下Unit4 The Panda Base 阅读课教学例，从文本解读、教学目标制定和教学活动的设计与实施三个角度深入剖析英语学习活动观在小学高年级阅读教学中的实践，以实现学生英语核心素养的发展。

简介：【摘要】众所周知，思维品质是学生必备的关键能力，它是培养学生综合语言运用能力的必要条件。但在我们的日常教学中，教师们更多地关注了语言知识的积累和语言技能的训练，缺乏从思维角度对文本进行的深入挖掘，难以有效地帮助学生形成和发展高阶思维。阅读教学“高投入、低产出”的现象已经成为发展学科核心素养中的短板，限制了学生综合语言应用能力的发展和提升。本文以一节英语牛津上海版9AU7 More practice的一节阅读拓展课为例，借助思维导图，从培养发展学生思维品质的视角，探讨如何在阅读课中提升学生思维品质。