简介:摘要卡波西水痘样疹临床上较少见,且多发生于3岁以内的婴幼儿,起病急,伴有发热等全身症状,治疗原则同水痘一样,如不严重,均是抗病毒治疗及防皮肤及全身感染的相关治疗,经上述治疗该患儿治愈出院,随诊无复发。
简介:Wnt-1induciblesignalingpathway-1(WISP-1),alsoknownasCCN-4,belongstotheconnectivetissuegrowthfactor(CTGF)family.WISP-1isprimarilyexpressedinembryonicstemcellsandisinvolvedinadultorgandevelopment.WISP-1participatesinmanycellularprocesses,includingproliferation,differentiation,apoptosisandadhesion.Inaddition,WISP-1playsanimportantroleindiversepathophysiologicalprocesses,suchasembryonicdevelopment,inflammation,injuryrepairsandcancers.RecentstudiesshowedthatWISP-1washighlycorrelatedwithtumorprogressionandmalignanttransformation,whereasitplayedanoncogenicroleincolorectalcancer,cholangiocarcinoma,hepatocellularcarcinomaandbreastcancer.However,interestingly,WISP-1exertsatumorsuppressingroleinlungandprostatecancers.WISP-1promotescellproliferation,adhesion,motility,invasion,metastasisandepithelial-to-mesenchymaltransitionviaparticularsignalingpathways.Inthisreview,wediscussedthestructure,expressionprofile,functions,clinicalsignificanceandpotentialmechanismsofWISP-1incancerandnon-neoplasticdiseases.
简介:Anticipatedbackwardstochasticdifferentialequation(ABSDE)studiedthefirsttimein2007isanewtypeofstochasticdifferentialequations.Inthispaper,weestablishageneralcomparisontheoremforABSDEs.
简介:目的:研究骨髓间充质干细胞(bonemarrowmesenchymalstemcells,BMMSC)成脂分化过程中转录因子SREBP-1对SIRT1的调控作用。方法:通过油红O染色鉴定BMMSC成脂分化;RT-PCR检测AP2、LPL、SREBF-1和SIRT1的mRNA转录水平;Western-blot检测SREBP-1表达水平;染色质免疫沉淀技术验证SREBP-1与SIRT1启动子之间的结合情况。结果:成脂诱导培养液中的BMMSC14d后被诱导成为成熟的脂肪细胞;RT-PCR显示AP2、LPL和SREBF-1、SIRT1在BMMSC成脂分化过程中表达上调;SREBP-1的蛋白水平也明显高表达;SREBP-1抗体免疫沉淀的基因组DNA成功扩增出SIRT1基因条带。结论:在BMMSC成脂分化过程中,SREBP-1能与SIRT1启动子区域特异性结合,可能参与SIRT1表达的调控。
简介:长链酰基辅酶A合成酶(longchainacyl-CoAsynthetase,LACS)是油脂代谢的重要催化酶。本研究采用RT-PCR技术,从花生(ArachishypogaeaL.)克隆到LACS1(GenBank登录号:KT932703),分析了该基因的结构组成,预测编码氨基酸与其他植物的同源性,采用实时Real-TimePCR技术对LACS1的组织表达进行研究。结果显示,花生LACS1基因全长2219bp,包含1992bp的ORF,编码663个氨基酸,有22个外显子和21个内含子。氨基酸序列比对显示花生LACS1有真核生物酰基辅酶A合成酶保守结构域,并含有保守的激活位点和绑定位点。同源性分析发现花生LACS1与大豆、野生大豆、鹰嘴豆、绿豆、甜橙等15种物种的氨基酸序列同源性在68%~86%之间,进化树分析显示,花生LACS1与鹰嘴豆等豆科植物亲缘较近。实时荧光PCR分析表明,花生LACS1在花生根、茎、叶、针、仁和花等组织均有表达,但差异明显,其中花的表达量最高,表达量大小顺序为花>针>叶>茎>根>仁,地上组织表达量高于地下组织。花生LACS1可能参与花生角质层的脂质合成。本研究结果为揭示植物脂肪酸代谢提供理论依据。
简介:AseriesofnovelN-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl)amidesderivativesweredesignedandsynthesized.Theirstructureswereconfirmedby1HNMR,13CNMRandHRMS.Alltitlecompoundswereevaluatedfortheirherbicidalandantifungalactivities.Preliminarybioassayresultsindicatedthatthetitlecompoundsshowedgoodtomoderateherbicidalactivityat1000mg/L.Compound6qpresentedthebestactivityagainstDigitariasanguinalis(L)Scop.,AmaranthusretroflexusL.andArabidopsisthalianawithaninhibitiondegreeoffive.Compound6dalsoshowedaninhibitiondegreeoffiveagainstD.sanguinalis.Inaddition,at50mg/L,mostcompoundsexhibitedgoodinvitroantifungalactivityagainstSclerotiniasclerotiorum,withcompound6cshowingover90%antifungalactivityagainstS.sclerotiorumandPelliculariasasakii.