简介：OnFebruary10,NationalMeetingonHealthandFamilyPlanningWorkwasheldinBeijing.Themeetinghadanin-depthstudyofthespiritsoftheEighteenthCPCNationalCongressandtheThirdPlenarySessionoftheEighteenthCentralCommitteeofthe

简介：AbstractBackground:Human epididymis secretory protein 4 (HE4) is a new ovarian cancer biomarker. The factors influencing HE4 levels are not clear, and the reference data in China are limited. Here, we aim to evaluate the effects of menopause and age on HE4 levels and to provide a possible reference value for HE4 in healthy Chinese people.Methods:A total of 2493 healthy females aged 40 years or older were recruited from March 2013 to March 2017 with the cooperation of four medical institutions across Beijing, China. The serum levels of HE4 and cancer antigen 125 (CA125) were measured by enzyme-linked immunosorbent assay. The Wilcoxon rank-sum test of variance and a stratified analysis were used to analyze the relationships among age, menopausal status, and levels of HE4 or CA125. Confidence intervals (5%-95%) were determined for reference ranges in different populations.Results:There was a statistically significant difference in median HE4 levels between the post-menopausal (n = 2168) and premenopausal groups (n = 325) (36.46 vs. 24.04 pmol/L, Z = -14.41, P < 0.001). HE4 increased significantly with age in the post-menopausal groups (H= 408.18, P < 0.001) but not in the pre-menopausal subjects (Z=-0.43, P= 0.67). The upper 95th percentile of HE4 levels were 44.63 pmol/L for pre-menopausal women, 78.17 pmol/L for post-menopausal women, and 73.3 pmol/L for all women. In the post-menopausal population, the HE4 reference ranges were 13.15 to 47.31, 14.31 to 58.04, 17.06 to 73.51, 24.50 to 115.25, and 35.71 to 212.37 pmol/L for different age groups from forty divided by decade. The CA125 level was affected mainly by menopausal status and not age.Conclusions:Menopausal status and age were both important factors influencing the level of HE4, and age affected HE4 levels mainly in post-menopausal women. The HE4 level was higher in the post-menopausal population than in the pre-menopausal population and increased with age.

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简介：EritreaislocatedinthecoastalareaofRedSeaintheeasternAfrica.Thecountryhasachievedindependenceforashorttime,theeconomyisunderdeveloped.ThemarketofprojectcontractofEritreahasattractedover10internationalcompaniesfromtheMiddleEast,EuropeandAsiaandPacific.Insuchafiercecompetition,SRBChasseizedthemarketopportunitytomakeanoutstandingperformanceandhasachievedconsiderablemarketshares.SRBChasenteredtheEritreamarketduringtheearlyperiodofitsindependence,duringthedevelopmentofthepastdecade,ithasmadethetotaloutputvalueofoverUS$60mil-

简介：AbstractBackground:Lipid abnormalities are prevalent among people living with human immunodeficiency virus (HIV) (PLWH) and contribute to increasing risk of cardiovascular events. This study aims to investigate the incidence of dyslipidemia and its risk factors in PLWH after receiving different first-line free antiretroviral regimens.Methods:PLWH who sought care at the Third People’s Hospital of Shenzhen from January 2014 to December 2018 were included, and the baseline characteristics and clinical data during the follow-up were collected, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). The risk factors of dyslipidemia after antiretroviral therapy were analyzed with the generalized estimating equation model.Results:Among the 7623 PLWH included, the mean levels of TC, HDL-C and LDL-C were 4.23 ± 0.85 mmol/L, 1.27 ± 0.29 mmol/L and 2.54 ± 0.65 mmol/L, respectively, and the median TG was 1.17 (IQR: 0.85-1.68) mmol/L. Compared with that in PLWH receiving tenofovir disoproxil fumarate (TDF) + lamivudine (3TC) + ritonavir-boosted lopinavir (LPV/r), zidovudine (AZT) + 3TC + efavirenz (EFV), and AZT + 3TC + LPV/r, the incidence of dyslipidemia was lower in PLWH receiving TDF + 3TC + EFV. In multivariate analysis, we found that the risks of elevations of TG, TC, and LDL-C were higher with TDF + 3TC + LPV/r (TG: odds ratio [OR] = 2.82, 95% confidence interval [CI]: 2.55-3.11, P < 0.001; TC: OR = 1.24, 95% CI: 1.14-1.35, P < 0.001; LDL: OR = 1.06, 95% CI: 1.00-1.12, P = 0.041), AZT + 3TC + EFV (TG: OR = 1.41, 95% CI: 1.28-1.55, P < 0.001; TC: OR = 1.43, 95% CI: 1.31-1.56, P < 0.001; LDL: OR = 1.18, 95% CI: 1.12-1.25, P < 0.001), and AZT + 3TC + LPV/r (TG: OR = 3.08, 95% CI: 2.65-3.59, P < 0.001; TC: OR = 2.40, 95% CI: 1.96-2.94, P < 0.001; LDL: OR = 1.52, 95% CI: 1.37-1.69, P < 0.001) than with TDF + 3TC + EFV, while treatment with TDF + 3TC + LPV/r was less likely to restore HDL-C levels compared with TDF + 3TC + EFV (OR = 0.95, 95% CI: 0.92-0.97, P < 0.001). In addition to antiretroviral regimens, antiretroviral therapy duration, older age, overweight, obesity and other traditional factors were also important risk factors for dyslipidemia.Conclusion:The incidence of dyslipidemia varies with different antiretroviral regimens, with TDF + 3TC + EFV having lower risk for dyslipidemia than the other first-line free antiretroviral regimens in China.

简介：摘要：“核心素养”这一概念首次在2014年3月教育部研制印发的《关于全面深化课程改革落实立德树人根本任务的意见》中被提出。2016年9月在《中国学生发展核心素养》中被正式公布。《普通高中英语课程标准（2017年版）》明确指出：“要倡导指向学科核心素养的英语学习活动观，设计有综合性、关联性和实践性特点的英语学习活动，是学生通过学习理解、应用实践、迁移创新等一系列融语言、文化、思维于一体的活动，获取、阐释和评判语篇意义，表达个人观点、意图和情感态度，分析中外文化异同，发展多元思维和批判性思维，提高英语学习能力和运用能力。”这标志着我国的教育从“素质教育”发展到了“核心素养教育”时代。作为普通高中英语教师要顺应时代发展潮流，除了传授英语基础知识，还要从“语言能力”、“思维品质”、“文化品格”、“学习能力”等四个维度去着手培养学生适应社会发展和终身发展的能力。

简介：摘要：单元整体教学是实现立德树人的有效途径，单元主题的选择是单元整体教学的首要环节，本文以八年级上册本文从课程标准、教材内容、语言目标和学生最近发展区五个方面来详细阐述初中英语学科单元主题的选择策略。

简介：MrChairman,Iwouldliketostartbycongratulatingyou,onbehalfoftheChineseGovernment,onyourassumptionoftheChairoftheinauguralsessionoftheHumanRightsCouncil.Ihaveeveryconfidencethatunderyourableleadershipthissessionwillbesuccessful.MrChairman,TheinaugurationoftheHumanRightsCouncilopensanewchapterinthecause

简介：【内容摘要】单元作业设计是教学的重要环节，是课堂教学的重要辅助。现阶段的作业布置存在许多弊端，为了优化作业设计，本文从对单元作业设计的现状分析出发，提出依托信息技术进行作业设计的优点，结合教学过程中的实践课例，从单元预习作业、单元课堂作业、单元课后作业3个方面阐明如何将信息技术合理地运用到作业设计中，以达到学生核心素养培养的目的。同时，本文也提出在实践过程中教师应注意的几个方面。

简介：RespectedChair,SeniorChineseleadersandofficials,Excellenciesanddignitaries,ExpertsandNGOrepresentatives,FriendsfromtheMedia,LadiesandGentlemen：Namaskar,NihauandGreetingstoallIamextremelypleasedtoonceagaincometoXian,theoldestoftheFourGreatAncientCapitalCitiesofChinaandcurrentlycapitalofShaanxiprovinceandattendtheFirstSCOPeople＇sForumbeinghostedandsponsoredbyChinaNGONetworkforInternationalExchanges（CNIE）.

简介：摘 要：本文主要对课程思政背景下中职英语阅读策略与方法进行讨论和研究，通过对课程思政意义、教育理念、中职英语教材《英语基础模块1》Unit 8 people and events 中阅读课教学设计的分析与把握，促进英语阅读课程形式更加多样、内容更加生动、效果更加显著，提升中职英语课堂效率和教学效果，促进中职学生德智体美劳全面发展。

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简介：摘要：作业是课堂教学的延续与完善，是达成英语核心素养实现课程目标的重要一环。本文以人教版八年级上册Unit 7 Will people have robots?为例，例谈基于“大观念“设计单元作业。在实践中总结出，设计前基于单元大观念育人蓝图思考课时目标；设计时基于课时目标和内容规划课时具体作业，以提升初中阶段学生的学习英语的主体意识，激发兴趣，发挥作业的育人功能。

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