简介: 小刘跟主任到W市出差,抽空到服装市场去转了转.W市的服装市场远近闻名,不光是因为这个市场大,而是因为这里的服装全,听人介绍,这里各式各样的世界名牌服装都有.……
简介:摘要目的探讨二维化学位移磁共振多体素氢谱(two-dimensional chemical shift magnetic resonance imaging of hydrogen proton spectroscopy,2D-CSI 1H-MRS)在无形态学改变儿童颞叶癫痫(temporal lobe epilepsy,TLE)患儿海马微观变化的价值。材料与方法回顾性分析36例患儿和20例健康对照组颞叶海马的波谱数据,分别观察性别、年龄与分布之间的关系;分析观察组单侧、双侧与对照组及观察组单侧的患侧与健侧海马磁共振波谱(MR spectroscopy,MRS)各代谢物信息比较。结果36例患儿中,男性及发生左侧颞叶的患儿多,但性别及发病部位分布比较差异无明显统计学意义(χ2=1.67,P>0.05);观察组双侧男性发病年龄较女性小(F=12.25,P=0.015);与对照组比较,观察组单侧及双侧N-乙酰天门冬氨酸(N-aectylaspartate,NAA)/肌酸(creatine,Cr)、NAA/胆碱(choline,Cho)、NAA/(Cho+Cr)降低(F=12.22、35.786、6.712;P<0.001),Cho/Cr升高(F=14.712,P<0.001),差异均具有统计学意义(P<0.05);观察组单侧的患侧与健侧比较NAA降低、Cho升高(P=0.034、0.016),差异均具有统计学意义(P<0.05)。结论2D-CSI 1H-MRS检查发现颞叶微观的异常,细胞分子水平的变化,因此是一种很有前途的评估儿童TLE的工具。
简介:目的探讨急性B前体淋巴细胞白血病(BCP-ALL)患儿iTR35调节性T细胞改变及其在BCP-ALL免疫发病机制中的作用。方法以2012年7月至2013年12月深圳市儿童医院血液肿瘤科诊断并住院治疗的BCP-ALL初诊患儿为BCP-ALL组,并分为高危、中危和标危;同期体检的健康儿童为对照组。分离外周血CD4+T细胞,采用流式细胞术检测外周血CD4+FOXP3-IL-10-TGF-β-IL-12p35+IL-27EBI3+(iTR35)、CD4+CD25highFOXP3+(Treg)细胞比例及IL-12p35、IL-27EBI3、pSTAT1、pSTAT4蛋白表达水平;实时荧光定量PCR检测CD4+T细胞IL-12Rβ2、gp130mRNA表达;ELISA检测血浆IL-35、IL-10水平。比较BCP-ALL组和对照组上述指标的差异。结果1BCP-ALL组48例(男29例),年龄2.3~11.0岁,平均5.2岁;高危11例,中危21例,标危16例。对照组32例(男21例),年龄2.6~10.8岁,平均5.1岁。两组年龄和性别构成差异均无统计学意义。2BCP-ALL组外周血iTR35细胞比例显著高于对照组(P〈0.001),其胞内IL-12p35、IL-27EBI3表达水平亦显著高于对照组(P〈0.001);3BCP-ALL组Treg细胞比例及其胞内IL-12p35、IL-27EBI3表达水平较对照组明显增高(P〈0.001),血浆IL-35水平及CD4+T细胞IL-12Rβ2、gp130、pSTAT1、pSTAT4表达均上调(P〈0.001),且血浆IL-35水平与iTR35细胞比例及其IL-12p35、IL-27EBI3表达呈正相关(r〉0.63,P〈0.05)。4BCP-ALL组高、中危患儿血浆IL-35水平和iTR35细胞比例显著高于标危患儿(P分别为〈0.001和0.002),高危和中危患儿间差异无统计学意义(P〉0.05)。结论iTR35细胞数量及功能异常可能是导致BCP-ALL患儿免疫功能低下的重要因素之一。
简介:Bytheturnofthecentury,thepeopleofTianjinareconfidentofgreetingtheglorious21stcenturywithtremendousachievementtheyhavemadesincethebeginningofthereformandopeningup.Fromthehistoricalperspective,withourforesightandperspectiveview,andwithourdauntlessspirit,we,thebiggestportcityinNorthChina,willgraspthehistoricalopportunityprovidedbytheboomingeconomicdevelopmentinChinaandAsiaforthe21stcentury,bringintoplayTianjin’sadvantagesingeography,
简介:<正>nthenewcentury,howcanthehumanbeingshemoremature?Certainly,science,technologyandthelevelofproductiveforcearcveryimportant,butonahigherspirituallevel,howshouldtheybehaveasrealhumanbeings?Reviewingthehistoryofhumanbeingsfromtheverybeginning,theoriginandthechangesofcivilizationarcfullofthewisdomofthehumanbeings.However,assoonastheweakpointsofthehumanbeings,suchasjealousy,prejudice,pride,haired,selfishnessanddistrustetc.mixtogetherandthentheforcewillspreadandexplode,whichcanleadtoendlessquarrelsanddisputesamongthem.Humanityisweakened,thestrongbulliestheweak,evendisastrousresults:instabilityofthesocietiesandwars.Togetherwiththese,economyisboggeddownanddestroyedandthenatureisdamaged,theprogressofcivili-x.ationencountersdifficultiesoneafteranother.Asaresult,thechainofcivilizationisbroken;cultureandartshavebeenreplacedbyignorance,brutalityandirrationalit
简介:PointZusanli(ST36)istheHe-SeapointofStomachMeridianofFootYangmingandalsooneofthereinforcingpointsofthewholebodyaswell.Itsmajortherapeuticeffectsareasfollows.Toregulatethestomachandintestinesandtolowertheup-adverseflowofaiThat'thebellyandabdomenareguardedbyZusanli(ST36)',thefirstphraseofSongofFourMajorPoints(SiZongXueGe),brieflyindicatesthatpointZusanli(ST36)hastheimportanttherapeuticeffectsonthediseaseofthegastrointestinalsystem.AlargenumberofresearchershowedthatpuncturingpointZusanli(ST36)hadthesignificantinfluence
简介:Towhatextentislawaclosedandautopoietic,andtowhatdegreeisitanopensysteminteractingwithothersocialstructures?1ThiscomplexquestioncanberegardedastheunderlyingguidelineofthepresentsurveyofAncientLaw.Thehistoricaldevelopmentoflaw,andprivatelawinparticular,wasnotthefocusofhistoricalandphilologicalstudiesinthetwentiethcentury.Attentionwaspaidtocertainstatutesofprominentlaw-giverssuchasHammurabiorSolon,orgrandlawcodificationssuchastheTwelveTables.
简介:Lidui(厉兑ST45)istheJing(井Well)pointoftheStomachMeridianofFoot-Yangming.It'seffectivetoreducetheheatfromthestomachortheStomachMeridian.TheStomachMeridianisabundantwithqiandblood,andisinchargeofhemopathy.So,inclinic,weoftenapplyLidui(ST45)pointbleedingmethodtothetreatmentofmanykindsofdiseasesandgetgoodtherapeuticeffects.Followingare3typicalcases.
简介:InthisreportweintendtodiscussadeploymentoftheGlobustoolkitsinregionalgridstructuredevotedforLHCphysicsanalysis,Oneofourpeculiaritiesispoornetworkconnectivityinbetweentwopartsofexperimentalcomputingnodes,Inearlystageofdeploymentwemetseveraltechnicaldifficultiesduetoseveralbugsandmalfunctions.AtPNPItheownCertificateAuthority(CA)wascreated.