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简介：李可教授，广东省兴宁县人，1953年生于昆明，1969年在云南化工厂工作，1977年考入昆明师范学院历史系读书，现任教于昆明学院历史系，是云南省中国近代史学会和云南省中法战争史学会副会长。

简介：一天晚上,在疯人院里,一个病人说:“我是拿破仑!”另一个说:“你怎么知道?”第一个人说:“上帝对我说的!”一会儿,一个声音从另一个房间传来:“我没说!”

简介：2008年4月16日，重庆市人民检察院党组书记、检察长余敏在荣昌县人民检察院调研工作时说：“荣昌检察院领导班子和这支队伍的精神状态让我们感到耳目一新；荣昌检察院从上到下凝聚着一种精气神；去年你们创造了一个奇迹，你们没有想到，我们也没有想到。”

简介：坐落在磁器口古镇的钟家院是典型的南北建筑风格大融合,天井宽敞,轴线对称严谨,颇有北方院落韵味和皇家园林风范。但其建筑材料所用小青瓦,建筑结构上的穿斗,又极具南方民居特色。

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简介：“办公室工作繁复而冗杂，很多成绩不能大张旗鼓去宣传，很多服务要尽量做到无形，很多事情要想在员工、组织的前面。这样的工作性质，决定了这个团队是一群默默无闻、无私奉献的‘老黄牛’。办公室团队所有成员都有个共识，讲求‘安’‘专’‘迷’，即安心本职，专注工作，迷恋事业。他们也正是这样，静得下心、沉得住气、守得住责。”

简介：2006年11月14日，陕西省水利厅在陕西院召开《陕西省水利电力勘测设计研究院志》终审会，会议由厅办公室副主任许灏主持，副厅长李润锁、厅水志办主任李献华及郭青梅、陈恒基、樊维翰等专家与会。评审组专家对志书内容进行了认真细致的审评，认为该志内容丰富，资料详实，编写体例符合规约要求，达到了成志标准，一致同意通过终审；同时对一些具体问题提出了进一步修改完善的意见。

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简介：Complicationsaremorefrequentinelderlypatientswithcoronaryheartdisease(CHD),suchasimpairedglucosetoleranceandconstipations.Itisalwaysdifficulttocurethesecomplicationsinclinicalpractice.Inthiscasewehadsuccessfullycuredaneighty-threeyearsoldmanwithCHDcomplicatingimpairedglucosetoleranceandconstipationbyintegratedChinese-Westernmedicine.

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简介：AbstractObjective:Most patients with advanced lung cancer have a poor prognosis. Recent studies have identified TRIM59 as a novel molecule that serves as a prognostic factor for the progression of non-small cell lung cancer. In the present study, we investigated the role of TRIM59 in predicting the prognosis of lung adenocarcinoma (LUAD) as well as the correlation between TRIM59 expression and immune infiltrates.Methods:We analyzed TRIM59 expression in normal and tumor tissues based on RNA-sequencing datasets from The Cancer Genome Atlas and Genotype-Tissue Expression databases. Forty-seven cases of LUAD tissues and their matching adjacent tissues were collected, and TRIM59 expression in tissue samples was demonstrated by immunohistochemistry. All tissue specimens were obtained under the approval of the Medical Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine (approval No. IR2019001101; approved on April 3, 2019). The immune cell scores were calculated using the CIBERSORT database. The Tumor Immune Estimation Resource database was used to analyze the correlation between TRIM59 and immune cell activities.Results:TRIM59 was up-regulated in most cancer types. High TRIM59 expression predicted a worse prognosis in patients with LUAD (overall survival, P= 0.00096; disease-specific survival, P= 0.00056; disease-free interval, P= 0.0009; progression-free interval, P= 0.0012). Moreover, TRIM59 was highly expressed in patients with LUAD who had a poorer prognosis. TRIM59 also showed a significant correlation with the ESTIMATE score (P = 0.04) and stromal score (P = 0.005) in patients with LUAD. Notably, a significant correlation between TRIM59 and the tumor mutation burden was found in LUAD but in no other cancer types (P < 0.001). Further investigation showed that TRIM59 had a significant correlation with gene markers on neutrophils and dendritic cells.Conclusion:TRIM59 is a potential prognosticator in LUAD and may be correlated with immune cell identification, immune cell infiltration, and immunotherapy checkpoints in LUAD.

简介：Wedevelopahybridoptofluidicmicrocavitybyplacingamicrospherewithadiameterrangingfrom1to4μminliquid-filledplano-planoFabry–Perot(FP)cavities,whichcanprovideanextremelyloweffectivemodevolumedownto0.3–5.1μm^3whilemaintainingahighQ-factorupto1×10^4–5×10^4andafinesseof~2000.Comparedtothepureplano-planoFPcavitiesthatareknowntosufferfromthelackofmodeconfinement,diffraction,andgeometricalwalk-offlossesaswellasbeinghighlysusceptibletomirrormisalignment,ourmicrosphere-integratedFP(MIFP)cavitiesshowstrongopticalconfinementinthelateraldirectionwithatightmoderadiusofonly0.4–0.9μmandhightolerancetomirrormisalignmentaslargeas2°.Withthemicrosphereservingasawaveguide,theMIFPisadvantageousoverafiber-sandwichedFPcavityduetotheopen-cavitydesignforanalytes/liquidstointeractstronglywiththeresonantmode,theeaseofassembly,andthepossibilitytoreplacethemicrosphere.Inthiswork,themaincharacteristicsoftheMIFP,includingQ-factor,finesse,effectivemoderadiusandvolume,andtheirdependenceonthesurroundingmedium’srefractiveindex,mirrorspacing,microspherepositioninsidetheFPcavity,andmirrormisalignment,aresystematicallyinvestigatedusingafinite-elementmethod.Then,byinsertingdye-dopedpolystyrenemicrospheresofvarioussizesintotheFPcavityfilledwithwater,weexperimentallyrealizesingle-modeMIFPoptofluidiclasersthathavealasingthresholdaslowasafewmicrojoulespersquaremillimeterandalasingspotradiusofonly~0.5μm.OurresultssuggestthattheMIFPcavitiesprovideapromisingtechnologyplatformfornovelphotonicdevicesandbiological/chemicaldetectionwithultra-smalldetectionvolumes.

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简介：一、问题的提出新增的"Integratingskills"板块提供了以听和读为主的综合性语言材料和活动,其目的是使学生通过综合运用所学语法、词汇,并通过读达到有效的"输出"该板块的阅读部分,旨在扩充文化信息、拓宽学生视野培养学生创新精神,并为学生顺利完成听力作铺垫。听力给学生提供了综合运用语言并提高其实践能力的空间。但

简介：Toimprovethereliabilityandaccuracyoftheglobalpositioningsystem(GPS)/microelectromechanicalsystem(MEMS)inertialnavigationsystem(INS)integratednavigationsystem,thispaperproposestwodifferentmethods.Basedonwaveletthresholddenoisingandfunctionalcoefficientautoregressive(FAR)modeling,acombineddataprocessingmethodispresentedforMEMSinertialsensor,andGPSattitudeinformationisalsointroducedtoimprovetheestimationaccuracyofMEMSinertialsensorerrors.ThenthepositioningaccuracyduringGPSsignalshortoutageisenhanced.ToimprovethepositioningaccuracywhenaGPSsignalisblockedforlongtimeandsolvetheproblemofthetraditionaladaptiveneuro-fuzzyinferencesystem(ANFIS)methodwithpoordynamicadaptationandlargecalculationamount,aself-constructiveANFIS(SCANFIS)combinedwiththeextendedKalmanfilter(EKF)isproposedforMEMS-INSerrorsmodelingandpredicting.Experimentalroadtestresultsvalidatetheefficiencyoftheproposedmethods.

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简介：<正>受中央统战部的委托,中央社会主义学院于1992年10月17日至22日召开了社院工作研讨会。出席会议的有地方社院代表61人。中央统战部、全国政协有关部门负责人和各民主党派、工商联负责学习培训工作的同志也出席了会议。中央统战部特邀顾问、中央社院党组书记宋堃和中央社院院长杨纪珂在开幕式和闭幕式上都讲了话。中央统战部常务副部长蒋民宽在闭幕式上讲了话。中央统战部副秘书长、中央社院副院长

简介：为加强医院文化建设，增强职工的凝聚力和战斗力，弘扬爱岗敬业、无私奉献精神。9月16日晚，市妇保院举办“托起生命的希望”院歌大赛。行管、临床、医技等科室的24支代表队参加。