简介:摘要孕妇27岁,孕1产0,因原发不孕行试管婴儿术,孕19周来我院做产科超声检查,使用GEVOLUSONE8彩色多普勒超声诊断仪,探头C5-1,频率3~5MHz,超声所见宫腔内探及胎儿回声,胎儿头颅光环完整,BPD(双顶径)4.5cm,FL(股骨)3.0cm,颜面部扫查所见双眼结构未见明显异常,眼距正常,鼻骨存在,长4mm,胎儿上唇正中连续性中断,范围0.3cm,心脏位于胸腔内,四腔结构存在,心轴未见明显异常,膈肌连续完整,胎儿腹壁正中可见缺损,范围约0.7cm,可见一不规则实性包块突出于腹腔外,范围4.1×2.6cm,其内可见胃泡、肝脏、肠管回声,周围可见羊膜包绕,脐带可显示长度仅11cm左右,见与胎盘以一直线型相连,未见螺旋状结构,脊柱形态异常,腰椎水平可见脊椎排列紊乱,局部成角弯曲,CDFI可见脐带腹壁入口位于实性团块旁,只见一条脐动脉与一条脐静脉。
简介:Autoantibodiesagainsttheα1-adrenoceptorwhichhadagonistactivityasnorepinephrinemightplayrolesintheprogressionofhypertension,butwhethertheautoantibodiescouldinducevascularremodelingasnorepinephrineisnotclear.Inthispaper,themodelswithantibodiesagainsttheα1-adrenoceptorweremadebyimmunizingWistarratswiththesynthesizedthesecondextracellularloopofα1-adrenoceptorpeptides.Thehomo-agemaleWistarratsreceivedBSAinthesameimmunizingmannerandmalespontaneoushypertensiverats(SHR)wereusedascontrol.Alltheratswereraisedforoneyear.Thebloodpressureandmorphologicalchangesofarteriesweremeasured.Intheend,despitethesystolicbloodpressureofimmunizedratshadnodifferencewithnormalcontrol,themediathicknessofaortasandratioofmediatolumeninthethird-orderarteriesofmesentericvasculaturewereincreasedinimmunizedrats.Theobservationwithelectronmicroscopeshowedthatthemitochondriaofvascularsmoothmusclecells(VSMCs)hadnotablehyperplasia,andtheinterstitialcollagenfibrilwasincreasedtoo.Theeffectsofpurifiedantibodiesagainstα1-adrenoceptorontheproliferationofculturedVSMCs,andtheexpressionsofc-jun,c-fosandα1-adrenoceptorweredetected.TheresultsshowedthattheantibodiescouldpromotetheproliferationofculturedVSMCs,andenhancetheexpressionofc-junbothinvitroandinvivo.Soweconcludedthatantibodiesagainsttheα1-adrenoceptorcouldcontributetovasculardamagesinratsbystimulatingthegrowthofVSMCswhichmightbecausedbytheincreasedc-junexpression,andmightplayparticularrolesinthepathologicalchangesofhypertension.