简介：TheaconitebelongstoplantsofgenusAconituminfamilyofRanunculaceaandhavenotableclinicalfunctionsintreatingrheumaticarthritis,heartfailure,etc.However,accidentsofaconitine(fromaconite)poisoningfrequentlyoccurtomanypeopletakingtheseherbs.

简介：Twonewsteroidalalkaloids,isoconkuressineandN-formylconessimine,togetherwith6knownsteroidalalkaloidsincludingconkuressine,conessine,isoconessimine,conimine,conarrhimine,andfuntudienine,wereisolatedfromtheseedsofHolarrhenaantidysenteriacaWall.exA.DC.Theirintrinsicantibacterialactivitiesandsynergisticeffectswithpenicillinandvancomycinwereanalyzedinmethicillinsensitivestaphylococcusaureus(MSSA)andmethicillinresistantstaphylococcusaureus(MRSA).Twoofthesteroidalalkaloidsincludingonenewcompound(N-formylconessimine)showedpotentialantibacterialactivityandpossessedsynergisticeffectswithpenicillinandvancomycin,respectively.

简介：Naturalproductshavegainedpopularityworldwideforpromotinghealthcare,aswellasdiseaseprevention.Alkaloidsareimportantchemicalcompoundsthatserveasarichreservoirfordrugdiscovery.Severalalkaloidsisolatedfromnaturalherbsexhibitantiproliferation,antibacterial,antiviral,insecticidal,andantimetastaticeffectsonvarioustypesofcancersbothinvitroandinvivo.Thispaperfocusesonthenaturally-derivedalkaloidssuchasberberine,matrine,piperine,fritillarine,andrhynchophylline,etc.,andsummarizestheactionmechanismsofthesecompounds.Basedontheinformationintheliteraturethatissummarizedinthispaper,theuseofalkaloidsasdrugsisverypromising,butmoreresearchandclinicaltrialsarenecessarybeforefinalrecommendationsonspecificalkaloidscanbemade.Followingthis,itishopedthatasaresultofthisreview,therewillbeagreaterawarenessoftheexcellentpromisethatnaturalalkaloidsshowforuseinthetherapyofdiseases.

简介：现在的学习被设计决定Pinelliapedatisecta的茎tuber的化学成分。化学成分被各种各样的色析法的技术，和他们的结构孤立并且净化根据物理化学的性质被阐明并且光谱数据。三新碱(加重1，2，和3)作为9-被获得并且识别((5-methoxypyridin-2-yl)甲基)-9H-purin-6-amine(1)，4-(2-(2，5-dioxopyrrolidin-1-yl)乙醇)苯基醋酸盐(2)，并且N-(9-((5-methoxypyridin-2-yl)甲基)-9H-purin-6-yl)acetamide(3)。这些混合物与人的颈的癌症HeLa房间为他们的cytotoxicity被作比较。混合物1和3显著地与是的IC50价值禁止了HeLa房间的增长3.02???????┱??????????????愠摮潲牧灡潨楬敤？？

简介：

简介：AIM:ToestablishamethodtosimultaneouslydeterminethemainfivealkaloidsofCatharanthusroseusfortracesamples,ahigh-performanceliquidchromatography–electrosprayionization-tandemmassspectrometry(HPLC-ESI-MS/MS)analysismethodwasdeveloped.METHOD:ThefiveCatharanthusalkaloids,vinblastine,vincristine,vinleurosine,vindoline,andcatharanthinewerechromatographicallyseparatedonaC18HPLCcolumn.Themobilephasewasmethanol-15nmol?L–1ammoniumacetatecontaining0.02%formicacid(65:35,V/V).ThequantificationofthesealkaloidswasbasedontheMultipleReactionMonitoring(MRM)mode.RESULTS:Thismethodwasvalidated,andtheresultsachievedtheaimsofthestudy.Theintra-andinter-dayprecisionandaccuracyofthefivealkaloidswerewithin1.2%-11.5%(RSD%)and-10.9%-10.5%(RE%).Therecoveryratesofthefivealkaloidsofsampleswerefrom79.9%to91.5%.Thefiveanalyteswerestableatroomtemperaturefor2h,at4°Cfor12h,andat-20°Cfortwoweeks.ThedevelopedmethodwasappliedsuccessfullytodeterminethecontentofthefivealkaloidsinthreeplantpartsofthreebatchesofC.roseuswithaminuteamountcollectedfromthreeregionsofChina.CONCLUSION:TheHPLC-ESI-MS/MSmethodcanbeusedforthesimultaneousdeterminationoffiveimportantalkaloidsintraceC.roseussamples.

简介：Despitetheadvancesincombinatorialorsyntheticchemistryandbioinformatics,recentliteraturehasdemonstratedtherelevanceofnatureandbiomassasasourceofnewmoleculestotreatdifferentpathologies,i.e.,bioactivecompoundsobtainedfromEcteinascidiaturbinatetotreatsometypesofcancerorrapamycinfromStreptomyceshygroscopicustopreventorganrejectionaftertransplant.Thistrend

简介：SophoraeFlavescentisRadix(SophoraflavescensAit.,SFR)andSophoraeTonkinensisRadixetRhizoma(S.tonkinensisGapnep.,STR)aretwocommonlyusedtraditionalChinesemedicinesfromSophora(Leguminosae)plants,whicharebelievedtopossesssimilarbioactivecomponentswithentirelydifferentclinicalapplications.InordertofindoutthecharacteristicchemicalconstituentspotentiallyleadingtotheuniquemedicinalpropertiesclaimedforeachofthetwocloselyrelatedTCMs,anHPLCfingerprintmethodwasdevelopedforanalysesofthealkaloidandflavonoidconstituentsofSFRandSTR,respectively,whichwerefurtherevaluatedandcomparedthroughsimilaritycalculationandhierarchicalclusteringanalysis(HCA).Theresultsfromthepresentstudyshowedthatthealkaloidfingerprintsofthetwoherbsweresimilar,withmanycomponentsco-existinginbothdrugsandvariousbatchesofsamplesfromdifferentspeciesbeingmixedtogetherintheHCAdendrogram.However,theirflavonoidconstituentsweretotallydifferentwithspecificfingerprintsbeingyieldedforeachherb,andfurtherHCAanalysisshowedthatthetestedsamplescouldalmostbeclearlydividedintotwogroupsbasedontheiroriginsofspecies.TheresultsfromthepresentstudyindicatedthattheflavonoidconstituentscouldserveasthedifferentiallydiagnosticconstituentsofSFRandSTRandmightpotentiallyattributedtotheirdistincttherapeuticeffects.